Biological weapons and biotechnology JAKUB DRMOLA Types -bacteria -anthrax, cholera, salmonela, tetanus, tularemia, yersinia pestis, ricketsia, typhus, Q fever, glanders -viruses -encephalitis, smallpox, marburg virus, ebola -fungis -toxins -botulotoxin, ricin, enterotoxin - -in some cases, animals can also be considered as biological weapons (dogs, dolphins, snakes, bees, …) Vectors of infection - -inhalation or consumption -through blood or skin -aerosol dispersal (trucks, planes, drones, missiles) -detonation (problematic) -infiltration (water, food, ventilation) -other organisms (humans, rats, flees, mosquitos, ...) Targets - -people -to kill -to incapacitate -animals -as food -as transport -plants -as food -against drugs Strategic and tactical aspects -operational support -demoralize enemy -attack population -annihilation -highly dependent on weather and environmental conditions -quite unpredictable -friendly fire -latent and hard to detect History - -ancient history (poisoned arrows, wells, during sieges, use of snakes and wasps, and even plague?) -native americans decimated by smallpox -vaccination discovered 1796 -deployed during WW1 -mostly against animals -deployed during WW2 -esp. by Japan in China (2-500 000 dead) -plans to attack USA: “Cherry Blossoms at Night” -other powers quite behind, eager to “learn” -very active development during Cold War on both sides Spanish Flu -1918-1920 -global population around 1,75 bil. -WW1 casualties: -15-20 mil. -WW2 casualties: -40-100 mil. -Spanish Flu: -50-100 mil. - - -Black Death: -75-200 mil. Terrorism and assassinations and others - -1978, Bulgarian dissident, Georgi Markov killed by ricin pellet -1984, Dalles, Rajneesh and salmonella -751 infected, 45 hospitalized -today known as Osho, still popular -1990-5, Aum Shinrikyo -unsuccessful attempts to deploy anthrax, botulin and ebola -2001, Bruce Ivins, anthrax letters -22 infected, 5 dead -ended with suicide, still unclear motivation - -many unfuliflled threats and plans from a number of organizations Image result for iraq bio weapon Current situation -development relatively cheap, but difficult -deployment very difficult -growing bacterial resistance -https://www.youtube.com/watch?v=plVk4NVIUh8 -can be directly gentically modified now -chimeras, deimunization, genetic targeting -can accidentally leak or be acquired by terrorists -engineered anti-material bioweapons possible Other controversies •designer babies •artificial organs •synthetic organisms •gene editing •gene drives • http://i.imgur.com/cm7iprw.gif