BIOCHEMISTRY II
              VSBC041p

LECTURES                                  4th Semester 2009


(On Tuesdays 11:20 – 12:10, Komenskeho nam.2, Large lecture Hall)


Week

Date


1

17 Feb.

Digestion and absorption of lipids. Blood plasma lipids and the major groups of lipoproteins.
Metabolic fate of chylomicrons and VLDL, the metabolism of HDL.

2

24 Feb.

The biosynthesis of steroid hormones. The synthesis and hydroxylation of calciol.

3

  3 Mar.

––

4

10 Mar.

The integration of intermediary metabolism at the tissue and organ level.

5

17 Mar.

The metabolic functions of the liver.

Catabolism of haemoglobin, bilirubin metabolism. Metabolism of iron.

6

24 Mar.

Biotransformation of xenobiotics.

7

31 Mar.

Control of metabolism. Mechanism of hormone and neurotransmitter action.

Types of cell membrane receptors, intracellular effects of ligand binding; intracellular receptors.

8

  7 Apr.

Nerve cells. Neurosecretion. The biosynthesis and inactivation of neurotransmitters,
neurotransmission across synapses. Cholinergic, adrenergic, and (inhibitory) gabaergic receptors.

9

14 Apr.

Body water, the movement of water between ECF and ICF, water excretion.

Ionic composition of blood plasma, gradients of Na^+ and K^+ across cell membranes.

10

21 Apr.

Osmolality of ECF, regulation of the ECF osmolality and volume, fluid and electrolyte balance.
Calcium and phosphates.

11

28 Apr.

Transport of O[2] and CO[2]. Metabolic pathways producing/consumpting H^+ ions. Buffer bases of
blood, blood plasma (concentrations of components), ICF, the parameters of acid-base status.

The role of the lung, the kidney, and the liver in maintaining acid-base balance.

12

  5 May

Normal renal functions. Glomerular filtration. Tubular resorption and secretion.

13

12 May

The major proteins of blood plasma. The blood-coagulation cascade, inhibition of clotting.
Fibrinogen, fibrin, fibrinolysis. Blood cells.

14

19 May

The specific immune response. Soluble and cell free antigens, immunoglobulin structures.
Circulating immune complexes, secondary reactions.

15

26 May

The extracellular matrix. Synthesis and post-translational modifications of collagen,
intermolecular crosslinks in collagen and elastin, proteoglycans. Calcification of bone,
regulation. Biochemical markers of bone resorption and formation.