Spring 2012

Biochemistry I                       SEMINARS


GENERAL MEDICINE, DENTISTRY


VSBC021s, ZLBC021s


Date


1. week

20. 2. – 24. 2.

Introduction into the metabolism of cells (differences between prokaryotic and eukaryotic cell,
compartmentation of metabolic processes, enzyme markers of cell fractions, non-covalent
interactions in the cell and their significance).


2. week

27. 2. – 2. 3.


Structure of haemoglobin and its relationship to the function. Hb types in the blood    of healthy
subjects, HbCO and MetHb, abnormal Hb types.


3. week

5. 3. – 9. 3.


Enzymes - reaction rate, progress curve, the Michaelis plot and K[m], enzyme inhibition.


4. week

12. 3. – 16. 3.


Coenzymes, their relationship to vitamins.


5. week

19. 3. – 23. 3.


Written test I – 25 questions (Haemoglobin, enzymology, coenzymes).

Membrane structure and assembly. Transport across membranes.


6. week

26. 3. – 30. 4.


Metabolism of glucose: Glycolysis under anaerobic and aerobic conditions and the oxidation of
pyruvate. Gluconeogenesis. Glycogenesis and glycogenolysis.


7. week

2. 4. – 6. 4.


Metabolism of proteins. Common features of amino acid conversion.

The synthesis of urea. Nitrogen balance.


8. week

10. 4. – 16. 4.


Important reactions in amino acid catabolism.


9. week

17. 4. – 23. 4.


Written test II- 25 questions (Membranes, membrane  transport, metabolism of saccharides and amino
acids.)

Biosynthesis and desaturation of fatty acids. The sources of essential fatty acids. Metabolism of
triacylglycerols.


10. week

24. 4. – 30. 4.


Peroxidation of lipids. Metabolism of phospholipids. Biosynthesis of eicosanoids.


11. week

2. 5. – 7. 5.


Written test III – 25 questions (Metabolism of lipids.)

The citric acid cycle.


12. week

9. 5. – 15. 5.


The respiratory chain and oxidative phosphorylation.


13. week

16. 5. – 22. 5.




Compensatory lessons.

Credit test for the students who did not reach the required limit 52/75.

14.-15. week

23.5. – 1. 6.

Anatomy dissections

Date


Recommended textbook: Táborská, Tomandl: Biochemistry I – Seminars, MU, Brno 2012

%


Conditions for giving the course-unit credit
  * Full (100%) attendance in seminars is the principal condition.
  * If any absence, it must be apologized through Department of Study Affairs up to five days.
  * If apology is recorded in Information System (IS), then student is allowed to make up the
absence according to teacher's instructions.
  * Three revision tests are written in seminars, semestral limit for credit is 52/75.
  * If the semestral limit is not fulfilled, student must write the Credit test (limit 12/30).
  * One repetition of the Credit test is approved.




Deadline for any issue (making up all missing and justified lessons, passing the credit test) is
14. 6. 2012.


Students that will not meet this requirement will not be given the course-unit credit.


Obtaining of course-unit credits of practices and seminars is the pre-requisite for registration to
the examination of Biochemistry I.