Spring 2013

Biochemistry I                       SEMINARS


GENERAL MEDICINE, DENTISTRY


VSBC021s, ZLBC021s


Date


1. week

18. 2. – 22. 2.

Introduction into the metabolism of cells (differences between prokaryotic and eukaryotic cell,
compartmentation of metabolic processes, enzyme markers of cell fractions, non-covalent
interactions in the cell and their significance).


2. week

25. 2. – 1. 3.


Structure of haemoglobin and its relationship to the function. Hb types in the blood    of healthy
subjects, HbCO and MetHb, abnormal Hb types.

3. week

4. 3. – 8. 3.

Enzymes - reaction rate, progress curve, the Michaelis plot and K[m], enzyme inhibition.

4. week

11. 3. – 15. 3.


Coenzymes, their relationship to vitamins.

5. week

18. 3. – 22. 3.


Membrane structure and assembly. Transport across membranes.

Written test I – 25 questions (Haemoglobin, enzymology, coenzymes).

6. week

25. 3. – 29. 4.


Metabolism of glucose: Glycolysis under anaerobic and aerobic conditions and the oxidation of
pyruvate. Gluconeogenesis. Glycogenesis and glycogenolysis.


^#Beginning the 7th week the weekly program starts on Tuesdays

7. week    #

2. 4. – 8. 4.


Metabolism of proteins. Common features of amino acid conversion.

The synthesis of urea. Nitrogen balance.

8. week

9. 4. – 15. 4.


Important reactions in amino acid catabolism.

9. week

16. 4. – 22. 4.


Biosynthesis and desaturation of fatty acids. The sources of essential fatty acids. Metabolism of
triacylglycerols.

Written test II- 25 questions (Membranes, membrane transport, metabolism of saccharides and amino
acids.)


10. week

23. 4. – 29. 4.


Peroxidation of lipids. Metabolism of phospholipids. Biosynthesis of eicosanoids.


11. week

30. 4. – 6. 5.


The citric acid cycle.

Written test III – 25 questions (Metabolism of lipids.)

12. week

7. 5. – 13. 5.


The respiratory chain and oxidative phosphorylation.

13.week

14.5.-20.5.


Replication, transcription, translation

14. week

21. 5. – 27. 5.



Compensatory lessons.

Credit test for the students who did not reach the required limit 52/75.

15. week

27. 5. – 31. 5.

Anatomy dissections

^



Recommended textbook: Táborská, Tomandl: Biochemistry I – Seminars, MU, Brno 2012

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Conditions for giving the course-unit credit
  * Full (100%) attendance in seminars is the principal condition.
  * If any absence, it must be apologized through Department of Study Affairs up to five days.
  * If apology is recorded in Information System (IS), then student is allowed to make up the
absence according to teacher's instructions.
  * Three revision tests are written in seminars, semestral limit for credit is 52/75.
  * If the semestral limit is not fulfilled, student must write the Credit test (limit 14/30).
  * All absences must be made up before writing the credit test.
  * One repetition of the Credit test is approved.




Deadline for any issue (making up all missing and justified lessons, passing the credit test) is
14. 6. 2013.


Students that will not meet this requirement will not be given the course-unit credit.


Obtaining of course-unit credits of practices and seminars is the pre-requisite for registration to
the examination of Biochemistry I.