Spring 2013

BIOCHEMISTRY II                                     LECTURES

GENERAL MEDICINE

VSBC041p



Date


1. week

19. 2.


Digestion and absorption of lipids. Blood plasma lipids and the major groups of lipoproteins.
Metabolic fate of chylomicrons and VLDL, the metabolism of HDL.



2. week

26. 2.


The biosynthesis of steroid hormones. The synthesis of calciols. Synthesis of thyroidal hormones.



3. week

5. 3.


The integration of intermediary metabolism at the tissue and organ level.



4. week

12. 3.


The metabolic functions of the liver.

Catabolism of hemoglobin, bilirubin metabolism. Metabolism of iron.



5. week

19. 3.


Biotransformation of xenobiotics. Two phases of biotransformation,

typical reactions, cytochrome P450. Metabolism of ethanol.


6. week

26. 3.


Control of metabolism. Mechanism of hormone and neurotransmitter action.

Types of cell membrane receptors, intracellular effects of ligand binding; intracellular receptors.



7. week

2. 4.



Metabolism of  nervous tissue. Neurosecretion. The biosynthesis and inactivation of
neurotransmitters, neurotransmission across synapses. Cholinergic, adrenergic, and (inhibitory)
gabaergic receptors.



8. week

9.  4.



Water and Na^+,  K^+ ions balance, osmolality of ECF, oncotic pressure


9. week

16. 4.

Metabolism of calcium , phosphates and fluorine. Hormones involved  in their metabolism.

10. week

23.  4.


Transport of O[2] and CO[2]. Metabolic pathways producing/consuming H^+ ions. Buffer bases of
blood, blood plasma (concentrations of components), ICF, the parameters of acid-base status.

The role of the lung, the kidney, and the liver in maintaining acid-base balance.


11. week

30. 4.


Normal renal functions. Glomerular filtration. Tubular resorption and secretion.



12. week

7. 5.


The extracellular matrix. Synthesis and post-translational modifications of collagen,
intermolecular crosslinks in collagen and elastin, proteoglycans. Calcification of bone,
regulation. Biochemical markers of bone resorption and formation.


13. week

14. 5.


The major proteins of blood plasma. Endothelial cells. The blood-coagulation cascade, inhibition of
clotting. Fibrinogen, fibrin, fibrinolysis.



14. week

21. 5.


Biochemistry of blood cells. Molecular principles of immunochemistry.



15. week

28. 5.

Make-up  lessons

Recommended literature: see the first lecture