Spring 2015

Biochemistry I                      SEMINARS


GENERAL MEDICINE, DENTISTRY


VSBC021s, ZLBC021s


Date


1. week

16. 2. – 20. 2.

Introduction into the metabolism of cells (differences between prokaryotic and eukaryotic cell,
compartmentation of metabolic processes, enzyme markers of cell fractions, non-covalent
interactions in the cell and their significance).


2. week

23. 2. – 27. 2.


Structure of haemoglobin and its relationship to the function. Hb types in the blood    of healthy
subjects, HbCO and MetHb, abnormal Hb types.

3. week

2. 3. – 6. 3.


Enzymes - reaction rate, progress curve, the Michaelis plot and K[m], enzyme inhibition.

4. week

9. 3. – 13. 3.


Coenzymes, their relationship to vitamins.

5. week

16. 3. – 20. 3.


Membrane structure and assembly. Transport across membranes.

Written test I – 25 questions (Haemoglobin, enzymology, coenzymes).

6. week

23. 3. – 27. 3.


Metabolism of glucose: Glycolysis under anaerobic and aerobic conditions and the oxidation of
pyruvate. Gluconeogenesis. Glycogenesis and glycogenolysis.

7. week

30. 3. – 3. 4.


Metabolism of proteins. Common features of amino acid conversion.

The synthesis of urea. Nitrogen balance.

8. week

#7. 4. – 13. 4.



^#Beginning the 8th week the weekly program starts on Tuesdays

Important reactions in amino acid catabolism.

9. week

14. 4. – 20. 4.


Biosynthesis and desaturation of fatty acids. The sources of essential fatty acids. Metabolism of
triacylglycerols.

Written test II- 25 questions (Membranes, membrane transport, metabolism of saccharides and amino
acids.)


10. week

21. 4. – 27. 4


Peroxidation of lipids. Metabolism of phospholipids. Biosynthesis of eicosanoids.


11. week

28. 4. – 4. 5.

The citric acid cycle.

Written test III – 25 questions (Metabolism of lipids.)

1.5. National holiday – groups 32, 35 have this seminar on 15.5.

12. week

5. 5. – 11. 5.


The respiratory chain and oxidative phosphorylation.

8.5. National holiday – groups 32, 35 have this seminar on 22.5.

13. week

12. 5. – 18. 5.


Replication, transcription, translation.

Groups 32, 35 do not have this seminar.

14. week

19. 5. – 22. 5.


Compensatory lessons.

Credit test for the students who did not reach the required limit 52/75.

15. week

25. – 29. 5.

Anatomy dissections

^








Recommended textbook: Táborská, Tomandl: Biochemistry I – Seminars, MU, Brno 2012


Conditions for giving the course-unit credit
  * Full (100%) attendance in seminars is the principal condition.
  * If any absence, it must be apologized through Department of Study Affairs up to five days.
  * If apology is recorded in Information System (IS), then student is allowed to make up the
absence according to teacher's instructions.
  * Three revision tests are written in seminars, semestral limit for credit is 52/75.
  * If the semestral limit is not fulfilled, student must write the Credit test (limit 14/30).
  * All absences must be made up before writing the credit test.
  * One repetition of the Credit test is approved.




Deadline for any issue (making up all missing and justified lessons, passing the credit test) is
11. 6. 2015.


Students that will not meet this requirement will not be given the course-unit credit.


Obtaining of course-unit credits of practices and seminars is the pre-requisite for registration to
the examination of Biochemistry I.