Age-related macular degeneration
Veronika Matušková
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Age-related macular degeneration (AMD)
ØThe most common cause of blindness in developped countries


ØAMD is multifactorial disease caused by combination of predisponing genes and influences of
external environment
•Age-related macular degeneration (AMD)

Metamorphopsia
Obr1b [USEMAP]
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Související obrázek
•Amsler grid

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C:\Dokumenty\Litomyšl\Obrázky\RPE.jpg Výsledek obrázku pro bruchs membrane



•Ethiopathogenesis of AMD
•¯RPE cells with age (apoptosis, necrosis)
•¯melanosoms
•lipofuscin accumulation
•apoptosis
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C:\Dokumenty\Litomyšl\Obrázky\RPE1.jpg

ØDry form of drusen, RPE AMD changes, geographic atrophy of RPE
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•Classification of AMD

•Drusen



•RPE changes



•Geographic atrophy of RPE cells
Holxcnerova OD CL


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•Classification of AMD
•Wet form of AMD
•Choroidal neovascularisation

ØCNV
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D:\Litomyšl\Obrázky\schéma CNV.jpg
•classical
•occult
•Classification of AMD
•minimally classic

•Choroidal neovascul membrane



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•CNV – classic
•Fluorescein angiography

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•CNV - occult
IM000023

•Optical coherence tomography
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Výsledek obrázku pro oct amd cnv

•Risc factors of AMD
•Genetic factors
•Race influences
•Gender and hormonal influences

•Vascular risc factors
•Environmental influences
•Antioxidants level
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•Risc factors of AMD
Výsledek obrázku pro losos

•Antioxidants
ØLutein and zeaxantin (the most important retinal carotenoids)


Therapy of AMD (summary)
ØDry form  - lutein, zeaxantin
ØWet form - Anti VEGF – intravitreal aplication

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