Adobe Systems
Physiology department
1
Arterial stiffness.

Adobe Systems
Physiology department
2
Factors of arterial stiffness changes
̶Elastin degradation
̶Collagen deposition
̶Endothelial dysfunction
!

Adobe Systems
Physiology department
3
Complications of the higher arterial stiffness

Adobe Systems
Physiology department
4
Pulse wave
Reflected wave
Forward systolic wave
t [s]
P[mmHg]

Adobe Systems
Physiology department
5
Pulse wave
Reflected wave
Forward systolic wave
t [s]
P[mmHg]
t [s]
P[mmHg]
SBP/P1
P2
DBP
PP=SBP – DBP
mBP=DBP+1/3PP
AP=P2 – P1
SBP – systolic blood pressure, DBP – diastolic blood pressure, P1 – pressure at peak of systolic
flow, P2 – pressure of the reflected wave, PP – pulse pressure, mBP – mean blood pressure, AP –
augmented pressure

Adobe Systems
Physiology department
6
Pulse wave at different vascular segments

Adobe Systems
Physiology department
7
Pressure wave reflection

Adobe Systems
Physiology department
8
Pressure wave reflection

Adobe Systems
Physiology department
9
Ultrasound measurement
age
IMTR (mm)
IMTL (mm)

Adobe Systems
Physiology department
10
PWV measurement
A highly compliant aorta has a relatively low PWV (< 6 m/s)

Adobe Systems
Physiology department
11
Ultrasound measurement (β – index).

Adobe Systems
Physiology department
12
CAVI measurement

Adobe Systems
Physiology department
13
CAVI measurement

Adobe Systems
Physiology department
14
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