MEDICAL CHEMISTRY   VSLC011p     1^st Semester^                      Autumn 2010

LECTURES
Wednesday 10:10 – 12:00

Week

Date


1

22 Sept.

Solutions of substances. Colligative properties of solutions, osmotic pressure.

Dissociation of electrolytes, the equilibria in electrolyte solutions.

Acid-base reactions: acids and bases, pH values, calculations.


2

29 Sept.

Hydrolysis of ions.

Buffers. Buffers in the human body.

Liquid colloid dispersions. Surfactants (tensides).


3

6 Oct.

Chemical reactions – kinetics, chemical equilibrium.

The driving force of chemical reactions, free Gibbs energy.


4

13 Oct.

Oxidation-reduction reactions. Redox potentials, the e.m. force of a voltaic cell and the relation
of it to the reaction free energy change and equilibrium constant.

Dissolution equilibria. Precipitation reactions.


5

20 Oct.

Essential macroelements important for living matter, properties of some of their compounds.
Hazardous inorganic chemicals.


6

27 Oct.

Biochemically important conversions of organic compounds (reactions of alcohols, oxidations and
reductions, the citric acid cycle, transaminations of amino acids).


7

3 Nov.

Heterocyclic compounds of biological importance

(cofactors, synthetic pharmaceuticals, drugs).


8

10 Nov.

Structures and properties of monosaccharides and simple sugar derivatives.

Oligosaccharides.


9

17 Nov.

-----------------legal holiday (substitutive lecture 22th December)


10

24 Nov.

Polysaccharides. Glycosides, nucleosides.

Nucleotides.


11

1 Dec.

Fatty acids and lipids-comprising alcohols. Triacylglycerols.

Phospholipids and glycolipids.


12

8 Dec.

Eicosanoids.

Isoprenoids. Steroids, structures of representative compounds.


13

15 Dec.

Standard a-amino acids, polarity of the side chains, ionization of amino acids, amino acids as
buffers.



22 Dec

Substitutive lecture Nucleic acids

14

 5 Jan.

Peptides, some examples of peptides exhibiting biological activity.

Proteins – main features of structures.

Globular, fibrous, and membrane proteins. Glycoproteins. Haemoproteins (haem and other
tetrapyrroles)



Recommended textbooks:

Táborská, Sláma, et al.: Medical Chemistry I (General and Inorganic Chemistry). Masaryk Univ., 2006

Dostál et al.: Medical Chemistry II (Bioorganic Chemistry). Masaryk University, 2006