opakovane1









ADVERSE EFFECTS OF DRUGS






•VERY COMMON (WITH OCCURRENCE FREQUENCY ≥10 %)
•COMMON (1 %- 10 %)
•UNCOMMON (0.1 % - 1 %)
•RARE (0.01 %- 0.1 %)
•VERY RARE (< 0,01 %)



















DRUG-DRUG INTERACTIONS
























DRUG DEVELOPMENT









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•PHASE 1 – HEALTHY VOLUNTEERS
•PHASE 2 – SMALL GROUP OF PATIENTS
•PHASE 3 – BIG TRIALS
•PHASE 4 – AFTER MARKETING (WHEN THE DRUG REACHED MARKET)