WEAPONS OF MASS DESTRUCTION BIOLOGICAL WEAPONS Kolářová Marie, EPI Autumn 2019 Biological agent A biological agent (also called bio-agent, biological threat agent, biological warfare agent, biological weapon, or bioweapon) is a bacterium, virus, protozoan, parasite, or fungus that can be used purposefully as a weapon in bioterrorism or biological warfare (BW). In addition to these living or replicating pathogens, toxins and biotoxins are also included among the bio-agents. More than 1,200 different kinds of potentially weaponizable bio-agents have been described and studied to date. Bioterrorism is the deliberate release of viruses, bacteria, toxins or other harmful agents to cause illness or death in people, animals, or plants. These agents are typically found in nature, but could be mutated or altered to increase their ability to cause disease, make them resistant to current medicines, or to increase their ability to be spread into the environment. Biological agents can be spread through the air, water, or in food. Biological agents are attractive to terrorists because they are extremely difficult to detect and do not cause illness for several hours to several days. Some bioterrorism agents, like the smallpox virus, can be spread from person to person and some, like anthrax, cannot. Kamran Afzal, PhD. , Asst Prof Microbiology Kamran Afzal, PhD. , Asst Prof Microbiology Kamran Afzal, PhD. , Asst Prof Microbiology Kamran Afzal, PhD. , Asst Prof Microbiology Kamran Afzal, PhD. , Asst Prof Microbiology Kamran Afzal, PhD. , Asst Prof Microbiology Kamran Afzal, PhD. , Asst Prof Microbiology Kamran Afzal, PhD. , Asst Prof Microbiology Kamran Afzal, PhD. , Asst Prof Microbiology Kamran Afzal, PhD. , Asst Prof Microbiology Kamran Afzal, PhD. , Asst Prof Microbiology Kamran Afzal, PhD. , Asst Prof Microbiology Kamran Afzal, PhD. , Asst Prof Microbiology Kamran Afzal, PhD. , Asst Prof Microbiology Kamran Afzal, PhD. , Asst Prof Microbiology Kamran Afzal, PhD. , Asst Prof Microbiology Kamran Afzal, PhD. , Asst Prof Microbiology Kamran Afzal, PhD. , Asst Prof Microbiology Kamran Afzal, PhD. , Asst Prof Microbiology Kamran Afzal, PhD. , Asst Prof Microbiology Kamran Afzal, PhD. , Asst Prof Microbiology Kamran Afzal, PhD. , Asst Prof Microbiology Kamran Afzal, PhD. , Asst Prof Microbiology Kamran Afzal, PhD. , Asst Prof Microbiology Kamran Afzal, PhD. , Asst Prof Microbiology Kamran Afzal, PhD. , Asst Prof Microbiology Kamran Afzal, PhD. , Asst Prof Microbiology Kamran Afzal, PhD. , Asst Prof Microbiology Kamran Afzal, PhD. , Asst Prof Microbiology Kamran Afzal, PhD. , Asst Prof Microbiology Kamran Afzal, PhD. , Asst Prof Microbiology Kamran Afzal, PhD. , Asst Prof Microbiology Kamran Afzal, PhD. , Asst Prof Microbiology Bacterial bio-agents (Military Symbol) Tularemia Francisella tularensis (SR or JT) Plague Yersinia pestis (LE) Melioidosis Burkholderia pseudomallei (HI) Listeriosis Listeria monocytogenes (TQ) Glanders Burkholderia mallei (LA) Dysentery (bacterial) Shigella dysenteriae, some species of Escherichia coli (Y) Diphtheria Corynebacterium diphtheriae (DK) Cholera Vibrio cholerae (HO) Brucellosis (porcine) Brucella suis (US, AB or NX) Brucellosis (caprine) Brucella melitensis (AM or BX) Brucellosis (bovine) Brucella abortus Anthrax Bacillus anthracis (N or TR) Psittacosis Chlamydophila psittaci (SI) Chlamydial bio-agents Rickettsial bio-agents Q Fever Coxiella burnetii (OU) Rocky Mountain spotted fever Rickettsia rickettsii (RI or UY) Typhus (human) Rickettsia prowazekii (YE) Typhus (murine) Rickettsia typhi (AV) Viral bio-agents Equine Encephalitis (Eastern) Eastern equine encephalitis virus (ZX) Equine Encephalitis (Venezuelan) Venezuelan Equine Encephalomyelitis virus (FX) Equine Encephalitis (Western) Western equine encephalitis virus (EV) Japanese B encephalitis Japanese encephalitis virus (AN) Rift Valley fever Rift Valley fever virus (FA) Smallpox Variola virus (ZL) Yellow fever Yellow fever virus (OJ or LU) Mycotic bio-agents Coccidiomycosis Coccidioides immitis (OC) Biological toxins Toxin Source of Toxin (Military Symbol) Abrin Rosary pea (Abrus precatorius) Botulinum toxins (A through G) Clostridium botulinum bacteria or spores, and several other Clostridial species. (X or XR) Ricin Castor bean (Ricinus communis) (W or WA) Saxitoxin Various marine and brackish cyanobacteria, such as Anabaena, Aphanizomenon, Lyngbya, and Cylindrospermopsis (TZ) Staphyloccocal enterotoxin B Staphylococcus aureus (UC or PG) Tetrodotoxin Various marine bacteria, including Vibrio alginolyticus, Pseudoalteromonas tetraodonis (PP) Trichothecene mycotoxins Various species of fungi, including Fusarium, Trichoderma, and Stachybotrys Biological vectors Vector (Military Symbol) Disease Mosquito (Aedes aegypti) (AP) Malaria, Dengue fever, Chikungunya, Yellow fever, other Arboviruses Oriental rat flea (Xenopsylla cheopis) Plague, Murine typhus