Viral hepatitis (VH)
A B C D E
Causative agent Picornaviridae Hepadnaviridae Raviviridae Deltaviridae Hepeviridae
nucleic acid RNA DNA RNA RNA RNA
Clinical features fever, malaise and abdominal discomfort
Association with
cirrhosis and
hepatocelular carcinom no + + with VHB no
fulminant %)
0,1 0,1-1,0 50 5 - 20
1-2 (10-20 in
pregnancy)
Incubation period (days)
15-50 28-180 15-160 ??? 15-45
The period of infectivity
Incubation period last 2 weeks last 2 months last 2 months ?? ??
acute illness first day entire period entire period ?? ??
transition to chronicity
% no 1 - 10 50 possible no
Output Port - infectious
biological material
faeces ++++ - - - +++
blood + viremia 1 day +++ ++ + --
genital secretions - +++ ++ ? Mode
of transmission fecal-oral + - - - +
by blood rarely + + + sexual
contact + + rarely +
vertical - + rarely + -
Imunization
Inactivatedhepatitis A
vaccines
active + passive
imunization
no no no