VIRAL HEPATITIS D
mkolar@med.muni.cz EPI; Autumn 2019
Hepatitis D (Delta) Virus
HBsAg
RNA
d antigen
• Coinfection
–severe acute disease
–low risk of chronic infection
• Superinfection
–usually develop chronic HDV infection
–high risk of severe chronic liver disease
Hepatitis D - Clinical Features
• Percutanous exposures
–injecting drug use
• Permucosal exposures
–sex contact
Hepatitis D Virus
Modes of Transmission
HBV - HDV Coinfection
Typical Serologic Course
Time after Exposure
Titer
anti-HBs
Symptoms
ALT Elevated
Total anti-HDV
IgM anti-HDV
HDV RNA
HBsAg
HBV - HDV Superinfection
Typical Serologic Course
Time after Exposure
Titer
Jaundice
Symptoms
ALT
Total anti-HDV
IgM anti-HDV
HDV RNA
HBsAg
Geographic Distribution of HDV Infection
HDV Prevalence
High
Intermediate
Low
Very Low
No Data
Taiwan
Pacific Islands
• HBV-HDV Coinfection
Pre or postexposure prophylaxis to prevent HBV
infection
• HBV-HDV Superinfection
Education to reduce risk behaviors among
persons with chronic HBV infection
Hepatitis D - Prevention