Pathophysiology – lectures
Autumn term 2020 – General medicine & Dentistry
UKB Kamenice 5 – A11/234
Tuesday 17:00 – 18:40
Week Date Topic
1 6/10 Pathophysiology of circulatory system I – myocardial metabolism - atherosclerosis - coronary
heart disease [Prof. MUDr. Kateřina Kaňková, PhD.]
2 13/10 Pathophysiology of circulatory system II –– ischemic heart disease – angina pectoris - acute
coronary syndromes – complications of acute myocardial infarction
[Prof. MUDr. Kateřina Kaňková, PhD.]
3 20/10 Pathophysiology as a medical discipline – health vs. disease – definition of major concepts
(aetiology, pathogenesis, syndrome/symptom etc.) with examples of a topic of circulatory
system [Prof. MUDr. Kateřina Kaňková, PhD.]
4 27/10 Pathophysiology of circulatory system III – pressure and volume overload (esp. systemic arterial
hypertension, heart and valve defects, cardiomyopathies) - systolic and diastolic dysfunction –
heart failure [Prof. MUDr. Anna Vašků, CSc.]
5 3/11 Pathophysiology of respiratory system I – blood gases exchange – ventilation / diffusion /
perfusion) disorders – ventilation-perfusion mismatch
[Prof. MUDr. Kateřina Kaňková, PhD.]
6 10/11 Pathophysiology of respiratory system II – control of ventilation – respiratory insufficiency
syndromes, pulmonary oedema, respiratory distress syndrome, selected restrictive lung diseases
[Prof. MUDr. Kateřina Kaňková, PhD.]
7 17/11 Public holiday
8 24/11 Pathophysiology of respiratory system III – obstructive diseases (bronchial asthma and COPD),
pulmonary hypertension [Prof. MUDr. Anna Vašků, CSc.]
9 1/12 Pathophysiology of respiratory system IV – disorders of pulmonary circulation – pulmonary
hypertension – classification of lung oedemas – pulmonary embolism – surfactant and
respiratory distress syndromes – selected restrictive pulmonary diseases
[Prof. MUDr. Julie Dobrovolná, PhD.]
10 8/12 Cell  tissue  organ  multicellular organism – regulation of proliferation, differentiation and
cell death (necrosis vs. apoptosis in the pathophysiological context), tissue injury – cytokines and
chemokines, acute inflammation, acute phase reaction - regeneration  reparation – wound
healing and its disorders [Doc. RNDr. Monika Pávková-Goldbergová, PhD.]
11 15/12 Chronic inflammation as a pathologic process – etiopathogenesis, consequences (esp. fibrosis)
examples, systemic inflammation (incl. sepsis), multi-organ dysfunction, SIRS, shock
[Prof. MUDr. Julie Dobrovolná, PhD.]
12 5/1 Cancer as a systemic disease - paraneoplastic syndromes – cancer cachexia – oncologic
emergencies [Prof. MUDr. Anna Vašků, CSc.]
13 12/1 Pathophysiology of kidneys I – glomerular haemodynamic – GFR and its quantification –
pathology of glom. filtration membrane – proteinuria, glomerulopathies incl. glomerulonephritis)
[Prof. MUDr. Kateřina Kaňková, PhD.]
14 19/1 Pathophysiology of kidneys II – acute kidney injury (AKI) and chronic renal failure
[Prof. MUDr. Kateřina Kaňková, PhD.]