LECTURE 7 – Preparations used to treat
some disorders of digestive system - I
Dr. Ivana Daňková
Dept. of Natural Drugs, Faculty of Pharmacy, VFU Brno
PHYTOPHARMACEUTICALS
academic year 2018/19
PHYTOPHARMACEUTICALS
vs. Digestive system (GIT = Gastrointestinal tract)
2
Major disorders of GIT that can be treat by phytomedicines:
 digestive disorders
 damaged mucosa of GIT
 ulceration
 inflammation (pharyngitis,
gastroenteritis)
 vomiting
 diarrhoea/constipation
 some cases of infection,
intoxication
Therapy of DIGESTIVE COMPLAINTS
3
Dyspepsia – general term for digestive disorders = indigestion.
Symptoms:
 pain in the upper abdomen
 heartburn (= pyrosis), hyperacidity
 feeling of fullness, distension
 belching, sickness, nausea
 bloating, flatulence, meteorism
 loss of appetite, poor appetite
 Dyspepsia is frequently caused by gastroesophageal reflux
disease (GERD) or gastritis, in a minority of other
impairment of digestive system function.
Therapy of DIGESTIVE COMPLAINTS
4
 stomachic drugs – digestion-stimulating, appetite-stimulating
drugs
 cholagogic drugs, cholagogues – encourage the production
and release of bile (fat digestion)
 carminatives – act against flatulence, meteorism
 spasmolytics – provide a mild relief for cramps (spasms) of
smooth muscle tissue
 antiphlogistics, anti-inflammatory agents – for healing of
inflamed mucosa of digestive tract – pharyngitis, gastroenteritis,
intestine catarrh
 drugs for the treatment of peptic ulcers – for acceleration
of healing to lessen the risk of dangerous complications
 laxatives/antidiarrhoeal agents
STOMACHIC DRUGS
5
 herbs that act most directly on the stomach, stimulate secretion
of gastric juice, increase gastric tonus and relieve the generalized
stomach pain and cramping. They can stimulate also pancreatic
secretion.
 Contra-indications
Do not use stomachic in case of:
 an acute stomach or intestine catarrh
(gastritis, enteritis, colitis)
 hyperacidity of the stomach
 an acute gastric or duodenal ulcers
 Crohn´s disease
 significant functional disorder of the liver, kidney,
in case of heart failure,...
 digestive disorders of unclear origin
STOMACHIC DRUGS
6
active constituents of plant drugs:
 essential oils – aromatic plant drugs (seeds, herbs), spices
 e.g. of the families Apiaceae, Lamiaceae, Lauraceae, Myristiceae,
Zingiberaceae, Pinaceae, Cupressaceae…
 bitter principles
 bitter-tasting compounds with no other pharmacological effects
 different structures – mainly terpenes, of plant families:
 Gentianaceae – monoterpenes (iridoids, secoiridoids,…)
 Asteraceae – sesquiterpenic lactones
 other bitter-tasting compounds: some flavonoids (e.g. in Citrus
aurantium pericarp), alkaloids (e.g. quinine of Cinchona bark)
STOMACHIC DRUGS
7
Plant drugs containing essential oils, e.g.:
 Apiaceae family – mainly fruits, or other plant parts – root, herb
 Anisi fructus – Pimpinella anisum, anise seed
 Foeniculi amari fructus – Foeniculum vulgare, fennel
 Carvi fructus – Carum carvi, caraway seed
 Coriandri fructus – Coriandrum sativum
 Levistici radix – Levisticum officinale
 Angelicae radix – Angelica archangelica
 herbs – e.g. parsley (Petroselinum), celery (Apium graveolens)
 Lamiaceae family – herbs
 Ocimum basilicum, Thymus vulgaris, Majorana hortensis, Salvia
officinalis, Satureja hortensis, Mentha sp., Origanum vulgare,
Rosmarinus officinalis,…
STOMACHIC DRUGS
8
Other plant drugs containing essential oils, e.g.:
 Calami aromatici rhizoma – Acorus calamus, Acoraceae,
sweet-flag
 Myristicae semen/flos – Myristica fragrans, Myristicaeae, nutmeg
 Zingiberis rhizoma – Zingiber officinale, Zingiberaceae, ginger
 Galangae rhizoma – Alpinia officinarum, Zingiberaceae, galanga
 Cardamomi fructus – Elettaria cardamomum, Zingiberaceae,
cardamom
 Cinnamomi cortex – Cinnamomum zeylanicum, Lauraceae,
cinnamon
 Anisi stellati fructus – Illicium verum, Illiciaceae, star anise
STOMACHIC DRUGS – essential oils
9
Acorus calamus
rhizome
Zingiber officinale
rhizome
Archangelica officinalis
root
Cinnamomum zeylanicum
bark
Illicium verum,
fruit
Elletaria cardamomum
fruit
Myristica fragrans
seed/flower
STOMACHIC DRUGS
10
Plant drugs containing bitter principles – terpenic structures
(iridois, secoiridoids, sesquiterpenic lactones,...):
 Gentianae radix – Gentiana lutea, Gentianaceae, gentian
 Centaurii herba – Centaurium erythraea, Gentianaceae, centaury
 Trifolii fibrini folium – Menyanthes trifoliata, Menyanthaceae,
common bogbean
 Absinthii herba – Artemisia absinthium, Asteraceae, wormwood
 Millefolii herba – Achillea millefolium, Asteraceae, yarrow
 Cnici benedicti herba – Cnicus benedictus, Asteraceae,
holy thistle
STOMACHIC DRUGS – bitter principles
11
Artemisia absinthium
herb
Centaurium erythraea
herb
Achillea millefolium
herb
Gentiana lutea
root
Menyanthes trifoliata
leaf Cnicus benedictus
herb
STOMACHIC DRUGS
12
Plant drugs containing bitter principles – terpenic structures, e.g.:
 Condurango cortex – Marsdenia condurango, Apocynaceae,
marsdenia
 Quassiae lignum – Quassia amara or Picrasma excelsa,
Simaroubaceae, amargo (bitter ash, quassia wood)
 Salviae folium – Salvia officinalis, Lamiaceae, red sage (picrosalvin)
Other bitter-tasting drugs, e.g.:
 Aurantii pericarpium – Citrus aurantium subsp. amara, Rutaceae –
bitter-orange peel – bitter-tasting flavonoids
 Lupuli flos – Humulus lupulus, Cannabaceae, hop
– bitter substances in resin (humulone, lupulone)
 Cinchonae cortex – Cinchona sp., Rubiaceae – alkaloid quinine
 Lichen islandicus – Cetraria islandica, Parmeliaceae, iceland moss
– bitter-tasting lichen acids
STOMACHIC DRUGS
13
Marsdenia condurango
bark
Cinchona sp.
bark
Salvia officinalis
leaf
Quassia amara
wood
Citrus aurantium
peel (pericarp)
Humulus lupulus
flowers
Lichen islandicus
STOMACHIC DRUGS
14
Other stomachic plant drugs, e.g.:
 Capsici fructus – Capsicum annuum, C. frutescens,
Solanaceae, pepper
 Piperis nigri fructus – Piper nigrum, Piperaceae, black pepper
CHOLAGOGUES
15
 = herbal drugs that support production and the flow of bile
into the small intestine
 choleretics
= direct cholagogues,
stimulate bile production
in liver
 cholekinetics
= indirect cholagogues,
promote the flow of bile from
the gall bladder into the duodenum
 The role of bile is partially that of facilitating fat digestion but
also of being a natural laxative
CHOLAGOGUES
16
 Indications of cholagogues:
 to stimulate normal contractions to deliver bile to the small
intestine
 for disorders caused by insufficient or congested bile, such as
intractable biliary constipation, jaundice and mild hepatitis
 for symptoms of indigestion of fat-soluble substances
 for helping the liver's detoxification work
 for gallstones, unless they are lodged in the bile duct and causing
a great deal of pain
 Contra-indications of cholagogues:
 painful gallstones, acute bilious colic, obstructive jaundice
 acute cholecystitis unless gallstones, acute viral hepatitis,
extremely toxic liver disorders
CHOLAGOGUES
17
 all bitter-tasting herbs are cholagogues to some degree
 active constituents of plant drugs:
 essential oils
 bitter principles – bitter-tasting compounds – terpenic
structures (iridoids, secoiridoids, diterpenes,..)
 some flavonoids and other phenolic structures
 some alkaloids – act as stimulators of liver function
(production of bile)
CHOLAGOGUES
18
Plant drugs containing essential oils and bitter terpenes,
e.g.:
 Menthae piperitae herba/folium – Mentha piperita, Lamiaceae,
peppermint
 Marrubii herba – Marrubium vulgare, Lamiaceae, white
horehound
 Taraxaci radix cum herba – Taraxacum officinale, Asteraceae,
dandelion
 sesquiterpenic lactones from Absinthii herba, Millefolii herba,…
 iridoids, secoiridoids from Gentianae radix, Centaurii herba,
Trifolii fibrini folium,…
CHOLAGOGIC HERBS
19
Mentha piperita
Marrubium vulgare
Artemisia absinthium
Taraxacum officinale
Centaurium erythraea
Achillea millefolium Gentiana luteaMenyanthes trifoliata
CHOLAGOGUES
20
Other plant drugs used as cholagogues, e.g.:
 Curcumae rhizoma – C. longa, C. xanthorrhiza, C. zedoaria,
Zingiberaceae, turmeric – phenolic compounds, essential oils
 Cynarae radix/folium – Cynara scolymus, Asteraceae, globe
artichoke – phenolic acids derivatives
 Boldo folium – Peumus boldus, Monimiaceae, boldo – alkaloids
 Berberis radicis cortex – Berberis vulgaris, Berberidaceae,
barberry – alkaloids
 Chelidonii herba – Chelidonium majus, Papaveraceae, greater
celandine – alkaloids
 Fumariae herba – Fumaria officinalis, Papaveraceae, fumitory
– alkaloids
CHOLAGOGIC HERBS
21
Curcuma longa
Cynara scolymus Chelidonium majus
Berberis
vulgaris
Fumaria officinalisPeumus boldus
CHOLAGOGUES
22
Other plant drugs used as cholagogues,
e.g.:
 Silybi mariani fructus (= Cardui mariae
fructus)
Silybum marianum (Carduus marianus),
Asteraceae, milk-thistle herb
 1.5-3% silymarin, a mixture of various
flavonoid derivatives (flavonolignans)
present only in the fruit – the principal
components are silybin, silichrystin,
silydianin
 used mostly as a hepatoprotective agent but
also as a component in preparations for
bilious disorders
Therapy of DIGESTIVE COMPLAINTS
23
Other plant drugs used in digestive
preparations, e.g.:
 Matricariae flos – Matricaria (Chamomilla)
recutita, Asteraceae, chamomille
 essential oils, terpenic lactones, mucilage,
flavonoids, coumarines
 as an antiphlogistic, spasmolytic,
carminative and stomachic; disinfectant,
calming properties
 Hyperici herba – Hypericum perforatum,
Hypericaceae, St.John´s wort
 flavonoids, other phenolics, essential oils,
tannins,…
 anti-inflammatory and healing properties
on mucose of gastrointestinal system
Therapy of DIGESTIVE COMPLAINTS
24
Other plant drugs used in digestive
preparations, e.g.:
 Agrimoniae herba – Agrimonia eupatoria,
Rosaceae, common agrimony
 tannins, flavonoids,…
 anti-inflammatory and healing properties
in GIT, astringent effect
 Aspalathi folium – Aspalathus linearis,
Fabaceae, rooibos
 mainly phenolic compounds (flavonoids,
chalcones, phenolic acids),…
 positive effect on digestion
DIGESTIVE PREPARATIONS
Drops, tinctures, medicinal solutions
25
 TINCTURA AMARA
 alcoholic extract (= tincture) of plant drugs containing bitter
principles
 maceration of four plant drugs in ethanol 60%:
 Absinthii herba 10 g
Trifolii fibrini folium 30 g
Aurantii pericarpium 30 g
Gentianae radix 30 g
 Spiritus dilutus 1340 g
 macerate 7 days at room temperature
and add:
 0.25 g Cinnamomi corticis etheroleum
DIGESTIVE PREPARATIONS
Drops, tinctures, medicinal solutions
26
 ORIGINAL SCHWEDENBITTER Drops
POR GTT SOL 1x500ML
(Riviera Handels GmbH, Austria)
 Extractum herbarum ethanolicum:
extr. Absinthii herba, Gentianae radix,
Angelicae radix, Calami rhizoma, Tormentillae
rhizoma, Gummiresina myrha, Taraxaci radix,
Marrubii herba, Zedoariae radix,
Myristicae semen/flos, Juglandis pericarpium,
Electuarium theriaca sine opio
 contains 38 % of alcohol (V/V)
 SUKL code: 0046796
OTC medicinal product
 ATC: V11 (Phytopharmaceuticals and animal
products)
DIGESTIVE PREPARATIONS
Drops, tinctures, medicinal solutions
27
 Dr. Theiss
SCHWEDEN BITTER
 mixture of 13 herbal drugs
 1 teaspoon before meal
(3 times daily), or 1-2
teaspoons after „heavy meal“
 CONDURANGO WINE
(Herbadent)
 malt wine enriched with
water-alcoholic extract of
Marsdenia condurango bark
 suitable for the treatment of
digestive disorders, in case of
loss of appetite
DIGESTIVE PREPARATIONS
Drops, tinctures, medicinal solutions
28
 KLOSTERFRAU MELISANA Concentrate
POR+DRM SOL 1X95ML
(Klosterfrau Berlin GmbH, Germany)
 oral drops, solution for external use
 Extractum herbarum ethanolicum 40,81 mg in 1 mL:
extr. Melissae folium 4,2 mg, Inulae radix 5,6 mg,
Angelicae radix 5,6 mg, Zingiberis radix 5,6 mg,
Caryophylli flos 2,3 mg, Galangae radix 2,3 mg,
Piperis nigri fructus 0,57 mg, Gentianae radix 5,6 mg,
Myristicae semen 0,57 mg, Aurantii pericarpium 5,6 mg,
Cinnamomi cortex 2,5 mg, Cassiae flos 0,29 mg,
Cardamomi fructus 0,08 mg
 contains 66.8 % of alcohol (V/V)
 SUKL code: 0066927
OTC medicinal product
 ATC: V11 (Phytopharmaceuticals and animal products)
DIGESTIVE PREPARATIONS
Drops, tinctures, medicinal solutions
29
 AMOL POR GTT SOL 1X100ML
(Takeda GmbH, Germany)
 oral drops, solution for external use
 Citronellae etheroleum 0.1 g
Caryophylli floris etheroleum 0.1 g
Cinnamomi zeylanici corticis etherol. 0.24 g
Citri etheroleum 0.57 g
Menthae piperitae etheroleum 0.24 g
Lavandulae etheroleum 0.24 g
Levomentholum 1.723 g
in 100 mL
 contains 68 % of alcohol (V/V)
 SUKL code: 0049027
OTC medicinal product
 ATC: V11 (Phytopharmaceuticals and animal products)
DIGESTIVE PREPARATIONS
Herbal teas
30
 STOMARAN
(Leros)
 20x 1.5 g or 1x 100g
 Angelicae radix
Calami rhizoma
Matricariae flos
Agrimoniae herba
Centaurii herba
Hyperici herba
Rubi fruticosi folium
Menthae pip. herba
Foeniculi amari fructus
 SUKL code: 0043959
 ATC: V11
 Properties: stomachic, digestive,
carminative, mild spasmolytic,
antiphlogistic, choleretic effects
 suitable for digestive disorders,
loss of appetite, flatulence,
feeling of fullness, abdominal
distension
 suitable also in case of
gallbladder disorders as a
support treatment
 for adults and children over 12y.
 CI: hypersensitivity to any
component, acute inflammation
of GIT, ulcerative disorders,
biliary obstruction
DIGESTIVE PREPARATIONS
Herbal teas
31
 STOMACHIC HERBAL TEA
(Megafyt Pharma)
 POR SPC 20X1.5GM
 Absinthii herba 300 mg
Menthae piperitae herba 300 mg
Millefolii herba 300 mg
Hyperici herba 150 mg
Levistici radix 150 mg
Liquiritiae radix 150 mg
Foeniculi fructus 150 mg
in 1 tea bag (1.5 g)
 SUKL code: 0076433
 ATC: V11
 suitable for digestive
disorders, loss of appetite,
flatulence, feeling of
fullness, abdominal
distension
 for adults and children over
12 years
DIGESTIVE PREPARATIONS
Herbal teas
32
 DIGESTIVE HERBAL TEA
(Megafyt Pharma)
 20 x 2.0 g
 Foeniculi fructus 30 %
Anisi fructus 30 %
Verbenae herba
Rubi idaei folium
Basilici herba
Aspalathi folium
(= rooibos)
Matricariae flos
Carvi fructus 4 %
Zingiberis rhizoma 2 %
 Leros Natur
DIGESTIVE Herbal Tea
 20 x 1.5 g
 Menthae piperitae herba 30 %
Cymbopogonis herba 20 %
(= lemongrass)
Serpylli herba 20 %
Carvi fructus 10 %
Matricariae flos 10 %
Zingiberis rhizoma 10 %
DIGESTIVE PREPARATIONS
Herbal teas
33
 STOMACH and INTESTINES
Herbal Tea (Teekanne)
 10 x 2.0 g
 Menthae piperitae folium 40 %
Matricariae flos 30 %
Liquiritiae radix
Cinnamomi cortex
Melissae folium 5%
 GASTRIC HERBAL TEA
with agrimony
(Apotheke)
 20 x1.5 g
 Millefolii herba
Agrimoniae herba
Hyperici herba
Matricariae flos
Calami rhizoma
Angelicae radix
CHOLAGOGIC PREPARATIONS
Drops, tinctures, medicinal solutions
34
 IBEROGAST POR GTT SOL 1x20ML
(STEIGERWALD Arzneimittelwerk GmbH)
 contains fluid hydro-alcoholic extract of:
Iberidis amarae herba, Angelicae radix,
Matricariae flos, Carvi fructus, Silybi mariani
fructus, Melissae folium, Menthae piperitae
folium, Chelidonii herba, Liquiritiae radix
 contains 32.6 % of alcohol (V/V)
 SUKL code: 0089031
OTC medicinal product
 ATC: V11 (Phytopharmaceuticals and animal
products)
 dosage: adults 20 drops 3 times daily,
children over 6y. 10 drops 3 times daily Iberis amara
Brassicaceae
CHOLAGOGIC PREPARATIONS
Drops, tinctures, medicinal solutions
35
 CHOLAGOL POR GTT SOL
1x20ML
(IVAX/TEVA)
 alcoholic/oil solution of:
Curcumae longae rhizomatis
pigmenta
Magnesii salicylas tetrahydricus
Menthae piperitae etheroleum
Eucalypti etheroleum
Frangula-emodinum
 contains 11.4 % of alcohol
 SUKL code: 0000699
OTC medicinal product
 ATC: A05AX
 Indications: cholelithiasis, chronic
cholecystitis, dyspeptic disorders
in chronic hepatopathy
 dosage: 5-10 drops 3 times daily.
 CI: hypersensitivity to any
component, acute inflammation of
gall bladder or liver, severe liver
damage, renal insufficiency
Not suitable for pregnant and
lactating women, children up to
12y. and for children up to 17y. in
feverish diseases
CHOLAGOGIC PREPARATIONS
Drops, tinctures, medicinal solutions
36
 ROWACHOL
POR GTT SOL 1x10ML
(STEIGERWALD)
 oral drops – solution of
essential oils in olive oil:
Pinenum 
Pinenum 
Camphenum
Cineolum
Menthonum
Levomentholum
Borneolum
 SUKL code: 0092087
OTC medicinal product
 ATC: V11
 available also in capsules
 ROWACHOL promotes bile
release, relives cramps in the
area of the gall bladder and biliary
tract, by reducing bile congestion
it promotes intermediary
metabolism in the liver. It reduces
cholesterol production in the liver
and decreases its concentration in
bile.
CHOLAGOGIC PREPARATIONS
Drops, tinctures, medicinal solutions
37
 BILIOUS Herbal Drops
(Grešík)
 10% alcoholic extract of:
Menthae piperitae herba
Taraxaci herba
Cichorii herba
Rubi fruticosi folium
Calendulae flos
Curcumae rhizoma
Agrimoniae herba
Marrubii herba
Inulae radix
 BILIOUS Herbal Drops
(Fytos)
 contains extracts of:
Taraxaci radix cum herba
Verbenae herba
Origani herba
Agrimoniae herba
Cichorii herba
Inulae radix
CHOLAGOGIC PREPARATIONS
Herbal teas
38
 THÉ SALVAT
(Leros)
 20x 1.0 g
 Matricariae flos
Frangulae cortex
Boldo folium
Agrimoniae herba
Marrubii herba
Menthae piperitae herba
Taraxaci radix cum herba
 SUKL code: 0056349
 ATC: V11
 do not boil (only infusion),
drink warm. Always prepare
fresh.
 suitable as a part of liver and gall
bladder diet
 for digestive disorders, support bile
production and flow, act against
flatulence, abdominal distension;
mild laxative effect
 for adults and children over 10y.
 CI: hypersensitivity to any
component, acute inflammation of
gall bladder, biliary obstruction,
bilious and intestinal congestion,
severe liver damage. Not suitable
for pregnant and lactating women.
CHOLAGOGIC PREPARATIONS
Herbal teas
39
 BILIOUS Herbal Tea
(Megafyt Pharma)
 POR SPC 20X1.5GM
 Menthae piperitae herba 525 mg
Agrimoniae herba 375 mg
Marrubii herba 375 mg
Rhei radix 225 mg
in 1 tea bag (1.5 g)
 SUKL code: 0053725
 ATC: V11
 tea support bile release
- suitable for digestive
disorders, loss of appetite,
flatulence, feeling of
fullness, abdominal
distension
 for adults and children
over 12y.
CHOLAGOGIC PREPARATIONS
Herbal teas
40
 LIVER–GALL BLADDER
Herbal Tea (Megafyt Pharma)
 20 x 1.5 g
 Menthae piperitae herba 30 %
Matricariae flos
Taraxaci radix cum herba 20 %
Foeniculi fructus 10 %
Cymbopogonis herba
(lemongrass)
Schisandrae fructus
Curcumae rhizoma 5 %
Agrimoniae herba
 LIVER–GALL BLADDER
Herbal Tea (Leros)
 20 x 1.5 g
 Taraxaci radix cum herba 30 %
Menthae piperitae herba 20 %
Matricariae flos 20 %
Foeniculi fructus 15 %
Agrimoniae herba 5 %
Curcumae rhizoma 5 %
Schisandrae fructus 5 %
CHOLAGOGIC PREPARATIONS
Herbal teas
41
 GALL BLADDER and
PANCREAS Herbal Tea
(Pavel Váňa)
 40 x 1.6 g
 Agrimoniae herba
Silybi mariani fructus
Helichrysi herba
Menthae piperitae herba
Inulae radix
 LIVER-GALL BLADDER
Herbal Tea (Teekanne)
 10 x 2.0 g
 Taraxaci radix cum herba
Menthae piperitae folium
Matricariae flos
Foeniculi fructus
Curcumae rhizoma
Millefolii herba/flos
Silybi mariani fructus
DIGESTIVE PREPARATIONS
Oral solid forms
42
GASTROVAL cps.
(Valentis)
 1 capsule contains:
 EnzyBlend 75 mg – enzymes of Aspergillus fungus
that participate on cleavage of proteins, lipids, sugars…
 Gentianae radix
Taraxaci radix
Silybi mariani fructus – dry extract
 usage: 2 capsules per day
during meal
CARMINATIVES
43
 = drugs that prevents formation
of gas in the gastrointestinal tract
or facilitates the expulsion of gas
from intestines
 flatulence is usually
accompanied by abdominal pain
and distension
 Carminative herbal preparations
are often mixtures of essential oils
and herbal spices
 Carminative drugs are usually
used also as spasmolytics
CARMINATIVES
44
Plant drugs used as carminative and spasmolytic agents, e.g.:
 Apiaceae family
 Anisi fructus, Foeniculi fructus, Carvi fructus, Coriandri fructus
Angelicae radix,...
 Lamiaceae family
 Menthae piperitae herba, Majoranae herba, Origani herba,
Rosmarini herba, Thymi herba,…
 others
 Matricariae flos – Matricaria recutita, Asteraceae,
German chamomille
 Chamomillae romanae flos – Anthemis nobilis (Chamaemelum
nobile), Asteraceae, Roman chamomille
 Caryophylli flos – Syzygium aromaticum, Myrtaceae, clove
 etc.
CARMINATIVE DRUGS
45
Pimpinella anisum
fruits
Foeniculum vulgare
fruits
Coriandrum sativum
fruits
Majorana hortensis
herb
Origanum vulgare
herb
Carum carvi
fruits
Anthemis nobilis
flower
Syzygium aromaticum
flower
CARMINATIVE PREPARATIONS
Drops, tinctures, medicinal solutions
46
 Matricariae flos
Matricaria recutita
(syn. Matricaria chamomilla,
Chamomilla recutita),
Asteraceae
(German) chamomile
 Matricariae flos is mainly used as an
antiphlogistic, spasmolytic,
carminative, stomachic agent.
 also ulcer-protecting, bactericidal,
fungicidal activity has been
demonstrated
 the main uses internally are for
gastrointestinal complaints (gastritis,
enteritis, colitis, flatulence, cramp-like
symptoms in the digestive tract) and
menstrual problems
CARMINATIVE PREPARATIONS
Herbal teas
47
 CHILDREN Herbal Tea with chamomile (Leros)
 POR SPC 75GM
 Matricariae flos 18 g
Foeniculi fructus 16,50 g
Menthae piperitae herba 9 g
Althaeae radix 7,50 g
Rubi fruticosi folium 7,50 g
Plantaginis folium 5,25 g
Lupuli flos 4,50 g
Serpylli herba 3,75 g
Sambuci nigrae flos 1,50 g
Liquiritiae radix 1,50 g
 SUKL code: 0094842
 ATC: V11
CARMINATIVE PREPARATIONS
Herbal teas
48
 CHILDREN Herbal Tea
(Megafyt Pharma)
 20 x1.5 g
 Matricariae flos 20 %
Menthae piperitae herba 15 %
Melissae herba
Verbenae herba
Tiliae flos
Foeniculi fructus 10 %
 suitable for children
over 6 months of age
 CHILDREN Herbal Tea
(Megafyt Pharma)
 20 x1.5 g
 Matricariae flos 375 mg
Menthae piperitae herba 375 mg
Althaeae radix 300 mg
Liquiritiae radix 300 mg
Foeniculi fructus 150 mg
in 1 tea bag (1.5 g)
 suitable for children
over 4 years
CARMINATIVE PREPARATIONS
Drops, tinctures, medicinal solutions
49
 AQUA CARMINATIVA ČL 2009
 Carvi etheroleum 0.1 g
 Citri etheroleum 0.1 g
 Citronellae etheroleum 0.1 g
 Coriandri etheroleum 0.1 g
 Foeniculi amari fructus etheroleum 0.1 g
 Menthae piperitae etheroleum 0.1 g
 Ethanolum 96% (V/V) 2.4 g
 Aqua purificata 997.0 g
 Talcum 5.0 g
CARMINATIVE PREPARATIONS
Drops, tinctures, medicinal solutions
50
 AQUA CARMINATIVA RUBRA ČL 2009
 Aurantii amari floris etheroleum 0.1 g
Carvi etheroleum 0.1 g
Caryophylli floris etheroleum 0.1 g
Cinnamomi zeylanici corticis etheroleum 0.1 g
Foeniculi amari fructus etheroleum 0.1 g
Myristicae etheroleum 0.1 g
Menthae piperitae etheroleum 0.1 g
Citronellae etheroleum 0.5 g
Coriandri etheroleum 0.5 g
Citri etheroleum 1.0 g
Ethanolum 96% (V/V) 6.2 g
Sirupus simplex 266.0 g
pigments 0.28 g
Aqua purificata ad 1333.0 g
Talcum 7.0 g
CARMINATIVE PREPARATIONS
Drops, tinctures, medicinal solutions
51
 CHAMOMILLA Teva
SOL 1X25ML
(IVAX/TEVA)
 solution for oral or external use
 Matricariae extractum fluidum
= liquid extract of Matricariae flos
 contains up to 53 % alcohol
 SUKL code: 0162391
OTC product
 ATC: V11
 extracts of Matricaria flowers are
mainly used for their antiinflammatory,
antiseptic and
spasmolytic properties. They
are stated to possess
carminative, mild sedative
properties and have been used
for flatulent nervous dyspepsia,
travel sickness, nasal catarrh,
restlessness and specifically for
gastrointestinal disturbance with
associated nervous irritability in
children
CARMINATIVE PREPARATIONS
Oral solid forms
52
 COLPERMIN
POR CPS ETD 20X187MG
(Tillotts Pharma AG)
 Menthae piperitae etheroleum 187 mg in 1 capsule
 SUKL code: 0169682
OTC medicinal product
 ATC: V11, A03AX
 dosage: 1 capsule 3 times daily
30-60 min before meal
 do not use in case of gastric hyperacidity
CARMINATIVE PREPARATIONS
For external use
53
 DOMIFLAN Baby
(Aromatica)
 Anisi stellati etheroleum
Foeniculi etheroleum
Carvi fructus – extract
Matricariae flos – extract
Rosmarini folium – extract
 suitable for children
over 1 month of age
 HBF Children Emulgel
Against Flatulence
(Herbacos)
 Matricariae flos etheroleum
Menthae piperitae etheroleum
Anisi fructus etheroleum
Foeniculi fructus etheroleum