□
Vasoprotective drugs
TomasGonec 7.11.2011
Vascular diseases
□ thrombophlebitis -thrombotic degenerative changes of vessel walls
□ varices - usually big veins on legs
□ haemorrhoids (piles) - vessels near rectum
Therapy
□ Heparin
□ Heparinoids
□ Local anesthetics
□ Non-steroid antiphlogistics
□ all in local forms of administration (unguent, cream, suppository)
Natural drugs
□ Aescin - mixture of saponines (triterpenic glycosides)
□ Rutin - flavonoid (quercetin glycoside)
□ Troxerutin - semisynthetic hydroxylated derivative of Rutin
□ Diosmin, Hesperidin - other flavonoids
Synthetic drugs Naphthazon, Aminaphton
a
□ analogues of flavones
□ lower lysozomal enzymes
Naphtazon
Aminaphton
Tribenosid
□ inflammation mediators antagonist
Dobesylate, Etamsylate
□ Prostaglandine antagonists
^ 2+
Ca
Dobesylate
H2N+(CH2CH3)2 Etamsylate