Medicinal chemistry at Faculty of Pharmacy of UVPS Brno
Medicinal Chemistry I: 2nd
year summer semester
Lectures:
General topics:
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history
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nomenclature
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physico-chemical properties and activity
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stuctural features and activity
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structure modifications: homlogy, analogy, isosterism...
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drugs biotransformation
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prodrugs
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drugs research, development, patents & good practices
Special topics
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weak and strong analgesics & antiinflammatory drugs
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general & local anaesthetics, muscle realaxants
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CNS agents: antipsychotics, antineurotics, antidepressants, stimulants,
cognitive enhancers, halucinogens
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sedatives, hypnotics, antiepileptics, antivomitics, antikinetics
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adrenergic receptors' agonists and antagonists
Medicinal Chemistry I: 2nd
year summer semester (February - May)
Seminars: every Tuesday from 7.30 (compulsory!)
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introduction into the discipline
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syntheses and metabolism of selected weak analgesics and NSAIDs
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syntheses of some opiod receptors' ligands
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syntheses and metabolism of some local & general anaesthetics
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history and syntheses of platinum anticancer drugs
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syntheses of some adrenergics & anobesics
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syntheses and metabolism of some antipsychotics
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syntheses and metabolism of some antidepressants
syntheses of selected adrenergic receptor antagonists
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final test ( credit)
Medicinal Chemistry II: 3rd
year winter semester
Lectures
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antibiotics & other antibacterial chemotherapeutics: sulfonamides, quinolones, nitrofuranes, tetracyclins,
β-lactameantibiotics: penicilines & cephalosporins, (poly)peptide antibiotics, aminoglycoside antibiotics,
macrolide antibiotics etc.
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antitubeculotics & antileprotics
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antiviral agents
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antimycotics
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antiparasitics: antiprotozoal & vermicidal agents; insecticides
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liver protectants, cholagogues, cholelitholytics
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drugs controlling blood clotting
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antihyperlipidemics
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drugs improving heart perfusion, cardiotonics, coronary vascular dilators
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anti-hypertensive drugs
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anti-arrythmics, drugs for erectile dysfunction
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diuretics
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laxatives & antidiarrhoics
● antacids & anti-ulcerative agents: proton pump inhibitors, H2
-antihistamines, gastric cytoprotectants
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anticancer drugs
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insuline(s) & other antidiabetics
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hormones: derived from one amino acid, drugs for thyroid gland, peptide hormones, steroid hormones
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medicines for biologic therapy
Medicinal Chemistry II: 3rd
year winter semester (September - December)
Laboratory practical classes
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every even Thursday from 11.15, compulsory
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synthesis of
– an antibacterial drug (sulfacetamide)
– a local anaesthetic (lidocaine)
– an NSAID (acetylsalicylic acid)
– an antiepileptic (phenytoin)
– an antimicrobial preservative (methyl- or other paraben)
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products are characterized by a chromatography; the identity is confirmed by NMR or IR spectra
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determination of
– pKa of a weakly acidic drug (phenytoin or nitrofurantoin)