Adrenergic receptor
antagonists
Seminar
Tomáš Goněc 2020
Synthesis of selected compounds
Tolazoline synthesis
Synthesis of selected compounds
Prazosin synthesis
Synthesis of selected compounds
Propranolol synthesis – two general methods used in other
betablockers synthesis as well
Synthesis of selected compounds
Metoprolol synthesis
Metabolism of Prazosin
Metabolism of Urapidil
N N
NH N
N
O
O
O
N N
NH N
N
O
O
O
H
N N
NH N
N
O
O
O
OH
N N
NH N
N
OH
O
O
Metabolism of Pindolol
Metabolism of Metoprolol
Metabolism of Carvedilol