NATURAL POLYMERS MU SCI 12 2018
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NATURAL POLYMERS 4
Hyaluronic acid
Dr. Ladislav Pospíšil
29716@mail.muni.cz
January 2018/12

HYALURONIC ACID 1
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NATURAL POLYMERS MU SCI 12 2018
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•Hyaluronic acid is an naturaly existing anionic, nonsulfated glycosaminoglycan and can be very
large, with its molecular weight often reaching the millions. Hyaluronic acid is a polymer of
disaccharides, themselves composed of D-glucuronic acid and N-acetyl-D-glucosamine, linked via
alternating β-(1→4) and β-(1→3) glycosidic bonds. Hyaluronic acid can be 25,000 disaccharide
repeats in length. Polymers of hyaluronic acid can range in size from 5,000 to 20,000,000 Da in
vivo. The average molecular weight in human synovial fluid is 3–4 million Da, and hyaluronic acid
purified from human umbilical cord is 3,140,000 Da. Hyaluronic acid is also a major component of
skin, where it is involved in tissue repair.
•Despite its simple primary Structure, exhibits the Hyaluronic acid  very different biological
Effects depending on the Molecular Weight and its space Arrangement.
•
800px-Hyaluronan.png

HYALURONIC ACID 2
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NATURAL POLYMERS MU SCI 12 2018
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•It was originally extracted from the Cockscomb
•The synthetic biotechnological Manufacture are mostly used now, what led  to the more widely
spread use of the HYALURONIC ACID •HYALURONIC ACID has the Ability to bind up to 1000 % w/w of the
Water, so approx. 100 g Water can be bound by only 1 g of the HYALURONIC ACID – it is hardly to
believe! •HYALURONIC ACID can be used for Spinning to NANOFIBRES

HYALURONIC ACID - BIOFUNCTION
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•• It prevents the Cell from infiltration of the Viruses and Bacteria to the Cell •• It modulates
the Inflammation by induction of the Cytokines and Chemokines*** releasing, it quenches the free
Oxygen Radicals, influencing teh Proliferation and Differentiation of the Cells •• It prevents the
Collagen Deposition and so encourages cicatricial free Healing of the Tissue
•• The analgesic Effect was also described
•• ……………..
*** small Proteins of the Cell, which have the Signal Function in the Cell

HYALURONIC ACID - USE
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•Medical uses
•Hyaluronic acid has been used in attempts to treat osteoarthritis of the knee via injecting it
into the joint. It has not been proven, however, to generate significant benefit and has
potentially severe adverse effects. •Dry, scaly skin such as that caused by atopic dermatitis may
be treated with skin lotion containing sodium hyaluronate as its active ingredient. •Hyaluronic
acid has been used in various formulations to create artificial tears to treat dry eye.
•Healing of the Burns
•Ophthalmology Surgery
•Aesthetic Surgery  - filling of the Wrinkles etc.
•Healing of the Wounds
•Cosmetic uses
•Hyaluronic acid is a common ingredient in skin-care products. Hyaluronic acid is used as a dermal
filler in cosmetic surgery. It is typically injected using either a classic sharp hypodermic needle
or a cannula. Complications include the severing of nerves and vessels, pain and bruising. In some
cases hyaluronic acid fillers result in a granulomatous foreign body reaction
•