Uncovering of the Structure and Reactivity Correlation of CO-photoreactions of
                              3-Hydroxyflavone-Based Acid-Base forms

                 Marina Russo,^† Peter Štacko, Lenka Karpíšková^†, Petr Klán^†,^*

^†Department of Chemistry and RECETOX, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic

The well-established toxicity of CO appears contradictory with its possible therapeutical function.
Indeed, barely in the last century was discover that CO is produced endogenously.

Studies of the effects of CO have demonstrated its potential to produce a variety of beneficial
health outcomes, including anti-inflammatory, anti-bacterial effects, and antiproliferative effects
on cancer.[1] Therefore, carbon monoxide-releasing molecules (CORMs), biologically compatible
agents allowing for defined administration of carbon monoxide into living organisms to circumvent
its acute toxicity, are of special interest.[2] A precise spatial and temporal control over the CO
release can be achieved via activation of the CORM by light (photoCORMs).

A good photoCORM should be stable under ambient conditions and soluble in aerobic aqueous
environments. It should release CO using light at wavelengths that do not have the potential to
impart cellular damage and may exhibit fluorescence to enable tracking in the cell.

Understanding the mechanism is a key step for designing new derivatives with improved properties
for biological applications, such as water solubility, higher quantum yield and the absorption
spectra in the visible light region.

The detailed mechanism of the photochemically induced CO release from
3-Hydroxy-2-phenyl-benzo[g]chromen-4-one has been studied in our group.[3]

For a deeper comprehending, an uncovered study of the structure and reactivity correlation of
CO-photoreactions of such class of compound will be presented in this station.
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[1] L. Vítek, H. Gbelcová, L. Muchová, R. Koníčková, J. Šuk, M. Zadinova, Z. Knejzlík, S. Ahmad, T.
Fujisawa, A. Ahmed, T. Ruml,  Digestive and Liver Disease 2014, 46 369-375.

[2] C. C. Romao, W. A. Blatter, J. D. Seixas, G. J. L. Bernades, Chem. Soc. Rev. 2012, 41,
3571-3583

[3] Russo M., Štacko P., Nachtigallová D., Klán P J. Org. Chem. 2020, 85, 3527-3537.