Porphyrin-Flavonol Conjugates for Efficient Delivery of
                                          Carbon Monoxide


                                  Andrea Ramundo,^1 Petr Klán*^,1
                                                 ^

^1Department of Chemistry and RECETOX, Masaryk University, Kamenice 5, 62500, Brno, Czech Republic

                                  e-mail: andre.ramundo@gmail.com


Carbon monoxide (CO) is known to be a toxic gas for mammals. It has been recognized as a signaling
molecule with anti-inflammatory and cell-protective properties, with possible applications in
clinical treatments.^1, 2 Light-activated CO-releasing molecules (photoCORMs) can provide a high
spatial and temporal control, allowing the drug to be delivered only into the targeted tissues when
required. However, many of well-known photoCORMs are based on heavy metal complexes, and short
irradiation wavelengths may be required for their release with evidently limited use under a
clinical scenario.

Herein, we present a platform that combines the excellent photoproperties of porphyrin, which acts
as an antenna and triplet sensitizer, with the CO releasing abilities of a flavonol derivative.^3





This work was supported by the Czech Science Foundation (GA21-01799S).


1    Verma, A.;  Hirsch, D.;  Glatt, C.;  Ronnett, G. Science 1993, 259, 381-384.

2    Motterlini, R.; Otterbein, L. E. Nat. Rev. Drug Discov. 2010, 9, 728-743.

3    Studer, L. S.; Brewer W. E.; Martinez, M. L.; Chou, P. J. Am. Chem. Soc. 1989, 111, 7643-7644.