Interactive Syllabus

Medicinal Chemistry: Definition and history. Drug nomenclature. Seminar: Organisation of seminars. Syntheses and metabolism of selected strong and weak analgesics and non- steroidal anti-inflammatory drugs (NSAIDs).

Physico-chemical descriptors and biological activity. Structure-Activity Relationships. Structure optimization. An introduction into Quantitative Structure-Activity Relationships (QSAR). Seminar: Syntheses and metabolism of analgesics (continued). Sytheses and metabolism of selected local and general anesthetics.

Structure modifications: homology, analogy, isomerism, isosterism etc. Seminar: Structure simplification. (Dr. Goněc)

Drugs research and development. Drug patents. Approvals of drug preparations. Good laboratory, manufacturing and clinical practices (GLP, GMP, GCP). Seminar: Syntheses of platinum anticancer drugs. (Mgr. Kroutil)

Structural features influencing drug action. Seminar: Syntheses and metabolism of selected antipsychotics.

Adrenergic receptor agonists directly and indirectly acting. Appetite suppressants and other antiobesics. Seminar: Synthesis and metabolism of selected adrenergics

Adrenergic receptor antagonists. Seminar: Synthesis and metabolism of selected adrenergic receptor antagonists

Drug biotransformation. Seminar: Metabolism and syntheses of antipychotics continued.

(April 27th) Prodrugs. Weak analgesics - part 1. Seminar: Synthesis and metabolism of selected antidepressants, anticonvulsants and antiepileptics.

(May 4th) Weak analgesics - part 2. Strong analgesics. Seminar: Metabolism and syntheses of antibacterial chemotherapeutics - part 1.

(May 11th) General and local anethetics, muscle relaxants. Seminar: Metabolism of antibacterial compounds 2

(May 18th) Antidepressants. CNS stimulants, cognitive enhancers, halucinogens. Seminar: Metabolism of selected antimycotics.

(May 25th) CNS drugs II.: Antipsychotics, anxiolytics, hypnotics, sedatives. Seminar: final credit test.