Biomolecular Chemistry – Field of study catalogue MU
“How living systems function - seen on a single atom granularity”
The field of biomolecular chemistry includes knowledge about the structure of biologically important (macro)molecules, and the relation between their structure and function. The field also includes methodology of carrying out and applying research on the 3-D structure and function of bio(macro)molecules. Technical background makes it possible to touch top methods in the field: computational chemistry and molecular modeling, methods of structural analysis using cryo-Electron Microscopy, x-ray diffraction and nuclear magnetic resonance, methods in biomolecular interactions studies, methods of molecular biology and microbiology, bioinformatics etc.
After successfully completing his/her studies the graduate is able to:
- To characterize basic methods leading to obtaining information about 3-D bio(macro)molecular structure.
- He/she is familier with different techniques to represent 3-D bio(macro)molecular structure.
- Is able to characterize relationships between 3-D bio(macro)molecular structure and biological function as well as ways to influence the biological function.
- to present all the above attributes in written as well as spoken English.
The goal of the doctoral studies program in Biomolecular Chemistry is to prepare specialists at the highest level who will be not only specialists with detailed knowledge of certain techniques, but creative thinkers with a broad overview of the field of structural biology with good foundations in theory. A graduate of the field gains deep knowledge and practical skills in one or more of the areas covered by the Biomolecular Chemistry program: computational chemistry and methods of molecular modeling, methods of structural analysis using x-ray diffraction and nuclear magnetic resonance, methods of molecular biology and microbiology, and bioinformatics. The graduate will be a researcher accustomed to working independently, capable of producing new observations on biomolecular structure and working with information acquired through professional journals and electronic databases. The graduate will be able to communicate in the English language in the form of publications in international journals, presentations to the professional public, and through informal consultations with colleagues. Although the graduate will be qualified mainly for an academic career, he will also be a specialist capable of serving in the commercial sphere, especially in biochemical and pharmaceutical research, working with biologically-oriented databases, and in fields using advanced methods of computational chemistry. As the experience of the past few years has shown, foreign contacts and study stays can help the graduate to find work at the top institutes abroad.
Annual individual study plans are assembled by the doctoral candidate in consultation with his supervisor. In creating and fulfilling the study plan, each student must adhere to the following rules and conditions:
1) At the beginning of each academic year, the student must attend a required two-hour, no-credit bloc lecture C7777 Working with Chemical Substances; attendance is a necessary requirement for enrollment in any classes in which chemical substances are handled (dissertation work, etc.)
2) During the course of study students must obtain 20 credits in courses expanding and deepening the student's knowledge selected from the subjects that are being offered at the Faculty of Science and other faculties of Masaryk University, and which the student did not take during his bachelor’s and master's studies. The suitability of a subject for doctoral studies is determined by the advisor. This category includes also XD101 Literature study (completed with a colloquium, 3 cr, can be enrol twice), C9870 and C8970 Scientific data presentation I and II (completed with a credit), S5030 (spring term)/ S5035 (autumn term) MU Life Sciences Seminar (completed with a credit, 2 cr) or XD104 Literature research (completed with a credit, max 5 cr).
3) Each semester students are obliged to complete NCBR seminar CC060 (spring term)/CB060 (autumn term) - completed with a credit, 2 credits.
4) Students re-enroll the subject Teaching assistance XD102 (credit value 1-10, totally 20 credits, completed with a credit), where they assist an authorized teacher providing seminar and laboratory teaching in Bachelor and Master degree programmes.
5) Students are obliged to enroll for and complete the subject XD106 Lecture for the scientific community (credit value 2-10, completed by colloquium), that demonstrates their ability to present the results of their research project at an international scientific forum.
6) Students re-enroll for the subject XD100 PhD Thesis (credit value 5-30, totally 160 credits, completed by the credit). Students are obliged to enroll the subject XD105 Scientific publication writing once during studies.
7) The student must gain 240 credits and successfully finish all parts of the state doctoral examination.
No special practical training (e.g., in industry) is required.
The student must show an ability to present his/her results in English in front of an international scientific forum.
The dissertation must contain the results published or accepted for publication. The preferred form is a set of publications or manuscripts accepted for publication dealing with the subject of dissertation, accompanied by a comprehensive introduction and commentary. In at least one of the publications the student must be the first author. At least three publications in peer-reviewed journals with impact factor are required; when the combined impact factor exceeds 4, the number of publications may be lower than three.
The student must gain 240 credits and successfully finish all parts of the state doctoral examination.
There are direct relationships with chemical disciplines (biochemistry, organic chemistry, physical chemistry..), biophysics, molecular biology and bioinformatics.