Průchod studijním plánem

The state doctoral examination consists of a dissertation defense and an oral examination in the chosen field of the Pharmacy doctoral program. As part of the state doctoral examination, deep theoretical knowledge is required in the chosen study program with a focus on a specialized subfield of study (Pharmacognosy and Phytochemistry, Pharmacology, Medicinal Chemistry, Pharmaceutical Technology, Social and Clinical Pharmacy). It is possible to take the state doctoral examination only after fulfilling the required obligations (passing the prescribed exams, obtaining the prescribed number of credits, submitting the dissertation and authorship of the DSP student on at least one publication in a scientific impact journal, where the student must be the first or corresponding author).

1) Within the educational part, the student completes the compulsory subjects Current Trends in Pharmaceutical Research as well as at least two subjects from compulsory elective subjects. The student chooses the subjects in such a way that they are related to the topic of his dissertation, and writes them down in the Individual Study Plan.
2) The activities and duties of doctoral students leading to the dissertation (Dissertation Thesis) thesis, whether study, research or other, accumulate at least 120 and at most 160 ECTS credits.
3) Demonstration of the ability to present knowledge gained through creative activity, within the framework of at least one contribution in a professional journal and/or two contributions at a conference, or in other recognized similar forms of applying the results of scientific and research activities.
4) Publication of at least one scientific article in a journal with an impact factor with a topic related to the dissertation
work, as the first or corresponding author of this article.
5) Completion of a part of the study at a foreign institution lasting at least one month (credit evaluation: 5 credits per week + 2 credits for each subsequent week) or participation in an international creative project with results published or presented abroad or another form of direct student participation in international cooperation.
6) Demonstration of the ability to present the knowledge gained within the study program, within the framework of teaching for undergraduate students and within the framework of lifelong learning. Teaching duties (max. 120 hours per course), credit evaluation 1 credit per 3 hours.

Isolation of plant secondary metabolites from selected species/taxons (with a focus on prenylated compounds), their structural analysis and biological activity assessment
Phytochemical analysis of Ficus species and isolation of compounds with antioxidant and anti-inflammatory activity
Isolation and analysis of biological active compounds of Schisandra chinensis
Development of innovative dosage forms using 3D print
Formulation and evaluation of lyophylized parenteral medicinal products
Formulation of a therapeutic system for transport of biologically active compounds to the colon
Evaluation of compatibility and determination of stability of selected medicines administered by infusion systems
Development and production of a dosage form containing a probiotic
A new bioactive hemostatic based on collagen and cellulose
Preparation of iminosulfurans as substances with potential biological activity
Preparation of new modified poly- and oligosaccharides as substances for pharmaceutical use
Innovation of analytical methods in the Czech Pharmacopoeia
Design, synthesis and screening of antimicrobial and cytotoxic activity of new (thio)semicarbazide derivatives and their cyclic analogues
New potential inhibitors of human carbonic anhydrases: synthesis and evaluation of biological activity
Synthesis and study of properties of selected cinnamic acid derivatives
Development and synthesis of new fluorescent probes based on cyanine dyes
Use of imaging methods in stroke research
Development of new chromatin modifying substances for anticancer therapy
Design and synthesis of new fluorophores for the detection of biomolecules
Determination of medicine-important sugars / sugar alcohols by HPLC with evaporative light-scattering detector (ELSD)
Real-world data on rare diseases and the possibilities of their use in HTA