aVLPF0622c Pathophysiology II - practice

Faculty of Medicine
spring 2021
Extent and Intensity
0/3/0. 3 credit(s). Type of Completion: z (credit).
Taught partially online.
MUDr. Vendula Bartáková, Ph.D. (seminar tutor)
MUDr. Kamil Ďuriš, Ph.D. (seminar tutor)
doc. MUDr. Jaromír Gumulec, Ph.D. (seminar tutor)
Ing. Hana Holcová Polanská, Ph.D. (seminar tutor)
Mgr. Katarína Chalásová, Ph.D. (seminar tutor)
MUDr. Michal Jurajda, Ph.D. (seminar tutor)
prof. MUDr. Kateřina Kaňková, Ph.D. (seminar tutor)
Mgr. Andrea Knight, Ph.D. (seminar tutor)
MUDr. Jan Máchal, Ph.D. (seminar tutor)
prof. RNDr. Michal Masařík, Ph.D. (seminar tutor)
MUDr. Stanislav Matoušek, Ph.D. (seminar tutor)
MUDr. Petr Müller, Ph.D. (seminar tutor)
Mgr. Lukáš Pácal, Ph.D. (seminar tutor)
prof. RNDr. Monika Pávková Goldbergová, Ph.D. (seminar tutor)
Mgr. Jana Šístková, Ph.D. (seminar tutor)
MUDr. Michal Šitina, Ph.D., M.Sc. (seminar tutor)
prof. MUDr. Anna Vašků, CSc. (seminar tutor)
Věra Ježková (assistant)
Mgr. Šárka Lakomá (assistant)
Mgr. Lucie Válková, Ph.D. (assistant)
Guaranteed by
prof. MUDr. Kateřina Kaňková, Ph.D.
Department of Pathophysiology – Theoretical Departments – Faculty of Medicine
Contact Person: prof. MUDr. Kateřina Kaňková, Ph.D.
Supplier department: Department of Pathophysiology – Theoretical Departments – Faculty of Medicine
Timetable of Seminar Groups
aVLPF0622c/30: Thu 13:00–15:30 A18/112, M. Jurajda, J. Máchal
aVLPF0622c/31: Thu 13:00–15:30 A18/112, M. Jurajda, J. Máchal
aVLPF0622c/32: Wed 14:00–16:30 A18/112
aVLPF0622c/33: Wed 14:00–16:30 A18/112
aVLPF0622c/34: Tue 10:00–12:30 A18/112
aVLPF0622c/35: Tue 10:00–12:30 A18/112
aVLPF0622c/36: Mon 13:00–15:30 A18/112, M. Jurajda, J. Máchal
aVLPF0622c/37: Mon 13:00–15:30 A18/112, M. Jurajda, J. Máchal
aVLPF0521c Pathophysiology I - practice && aVLBC0422p Biochemistry II - lect. && aVLFY0422p Physiology II - lecture
Physiology, biochemistry
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The objective of the practical exercises and seminars from pathological physiology is to provide students basic idea about pathological states and experimental work. Students will also acquire practical skills necessary for their subsequent(future) study and work.
Learning outcomes
Student will explain the explain the pathophysiology of GIT with a focus on stomach function;
Student demonstrates the principle of load test (oGTT) in an animal model of experimentally induced diabetes (alloxan);
Student shall identify clinically relevant parameters describe nutritional status (calorimetry, BMI, WHR index, the weight, the skin-fold thickness, bioimpedance, DEXA) ;
Student demonstrates onset of obstruction icterus induced by ligation of ductus choledochus. He understands etiopathogenesis of other types of icterus (hemolytic, hepatic) and diagnostics of them using heme metabolites in urine, blood and stool using mitochondrial/cytoplasmatic membranes liver enzymes;
Student demonstrates the pathophysiology of selected skin diseases;
Student demonstrates the examination of the quality of the skin barrier, through the examination of resistance and conductivity of the skin or a chemical (Burckhardt´s) examination with regard to the composition of the skin barrier;
Student will explain the importance and principles of DNA diagnostics and other molecular-biological methods;
Student describes etiopathogenesis of venous thrombosis using data from experimental animal model;
Student discusses hematological consequences of radiation syndrome;
Student discusses changes in blood flow in the splanchnic area with respect to vasoactive effects;
Student discusses cerebrovascular disease, intracranial hypertension with regard to etiology;
Student discusses the connection with the development and progression of shock states with regard to the pathophysiology of anaphylactic shock.
  • Pathophysiology of GIT (tutorial). Exp. induced diabetes mellitus preparation. Exp. induced diabetes mellitus – diagnosis by glucose tolerance test Overview of molecular biology exp. methods used in pathophysiology (tutorial & demonstration of selected lab. methods) Obstructive jaundice I - preparation Exp. induced jaundice in lab. animal Radiation Radiation II, haematological microscopy Haematology, blood transfusion (tutorial) Exp. induced changes of blood flow in splanchnic region in experimental animal Exp. induced vein thrombosis Anaphylactic reaction, pathophysiology of circulatory shock (tutorial) Statistical evaluation of experiments (advanced methods), practical analysis of exp. data (using stat. software) Neuropathophysiology I - – cerebrovascular disorders, intracranial hypertension (bleeding, liquor, …) (tutorial) Pathophysiology of skin disorders
Teaching methods
practical exercises in lab, seminars
Assessment methods
Practicals are compulsory (the only permited reason for not attending is a student's sick leave). Students can be given written tests or individual home work by tutor's throughout the term. Student's participation in the practicals throughout the term is certified by a credit given upon the following conditions: (i) complete attendance, (ii) complete protocols from the exp. practicals, (iii) indicidual criteria announced by the principal tutor.
Language of instruction
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Information on the extent and intensity of the course: 45.
Listed among pre-requisites of other courses
Teacher's information
The course is also listed under the following terms Spring 2018, spring 2019, spring 2020, spring 2022, spring 2023, spring 2024.
  • Enrolment Statistics (spring 2021, recent)
  • Permalink: https://is.muni.cz/course/med/spring2021/aVLPF0622c