FAFO2_13 Dosage Forms and Biopharmacy II

Farmaceutická fakulta
jaro 2025
Rozsah
3/6/0. 11 kr. Ukončení: zk.
Vyučováno kontaktně
Vyučující
doc. PharmDr. Aleš Franc, Ph.D. (přednášející)
doc. PharmDr. Jan Gajdziok, Ph.D. (přednášející)
doc. PharmDr. Kateřina Kubová, Ph.D. (přednášející)
PharmDr. Jakub Vysloužil, Ph.D. (přednášející)
doc. PharmDr. Aleš Franc, Ph.D. (cvičící)
doc. PharmDr. Jan Gajdziok, Ph.D. (cvičící)
doc. PharmDr. Kateřina Kubová, Ph.D. (cvičící)
PharmDr. Jakub Vysloužil, Ph.D. (cvičící)
PharmDr. Kateřina Brückner, Ph.D. (cvičící)
PharmDr. Hana Hořavová (cvičící)
PharmDr. Miroslava Pavelková, Ph.D. (cvičící)
PharmDr. Jiří Zeman, Ph.D. (cvičící)
Garance
doc. PharmDr. Kateřina Kubová, Ph.D.
Ústav farmaceutické technologie – Ústavy – Farmaceutická fakulta
Rozvrh
Čt 9:15–11:45 18-122
  • Rozvrh seminárních/paralelních skupin:
FAFO2_13/01: Čt 13:00–14:30 18-122, Čt 14:30–18:00 18-107, K. Brückner, A. Franc, J. Gajdziok, H. Hořavová, K. Kubová, M. Pavelková, J. Vysloužil, J. Zeman
FAFO2_13/02: Čt 13:00–18:00 18-138, K. Brückner, A. Franc, J. Gajdziok, H. Hořavová, K. Kubová, M. Pavelková, J. Vysloužil, J. Zeman
Předpoklady
FAFO1_13 Dosage Forms and Biopharmacy
Dosage Forms and Biopharmacy I
Students can study this course only after completing the course Dosage Forms and Biopharmacy I
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Cíle předmětu
One of the main obligatory pharmaceutical disciplines dealing with preparation, manufacturing and quality control of medicaments including technological procedures, equiment, excipients and appropriate analytical devices. It covers the influence of the application form on drug bioavailability.
Výstupy z učení
After completing the course, the student will:
- describe the theoretical aspects of semisolid dosage forms formulation and quality testing;
- describe the classification, requirements, excipients, and technological process of preparation and production of solid dosage forms, including their evaluation;
- theoretically describe the classification, requirements, excipients, technological process of preparation and production of dosage forms with controlled drug release, including their evaluation;
- know the basic aspects of semisolid and solid dosage forms about the drug bioavailability;
- describe the main conditions of GMP
- recognize selected incompatibilities in liquid and semisolid dosage forms and adjust the composition of pharmaceutical products;
- prepare semisolid (ointments, cremes, pastes, gels) and solid dosage forms (powders, granules, capsules, suppositories, vaginal globules) in pharmacy conditions
Osnova
Topic of lecture
1. Dosage forms for rectal application
2. Dosage forms for vaginal application
3. Granules, granulation methods. Evaluation of powders and granules
4. Tablets, their production, and evaluation
5. Pharmaceutical incompatibilities in dosage forms
6. Coated products, their production and evaluation
7. Development of new drugs from galenical perspective
8. Multiple-unit drug delivery systems
9. Pharmaceutical aerodispersions
10. Transdermal preparations
11. Public Holiday
12. Public Holiday
13. Controlled drug release
14. Good manufacturing practice in pharmacy

Practical labs
20.02.2025 Semisolid dosage forms - Ointments
27.02.2025 Semisolid dosage forms - Creams
06.03.2025 Semisolid dosage forms - Pastes, Gels
13.03.2025 Rectal and vaginal dosage forms - theoretical aspect of preparation, callibration coefficient Test - semisolid preparation.
20.03.2025 Rectal suppositories. Preparation of suppositories with known and unknown base replacement coefficients. Evaluation of suppositories.
27.03.2025 Vaginal globules, preparation by the Starke method, vaginal globules made from lipophilic bases. Preparation and evaluation. Test suppositories, vaginal globules
03.04.2025 Technological processes in preparation of difficult prescriptions I.
10.04.2025 Technological processes in preparation of difficult prescriptions II.
17.04.2025 Catch-up week
24.04.2025 Wet and melt granulations/Fluid bed granulation
01.05.2025 Public holiday
08.05.2025 Public holiday
15.05.2025 Tablets preparation by direct compression/Evaluation of solid dosage forms.
22.05.2025 Credit test, Laboratory skills testing
Literatura
    doporučená literatura
  • European Pharmacopoeia 11
  • MAHATO, Ram I. Pharmaceutical dosage forms and drug delivery. Boca Raton, FL: CRC Press, 2007, xxxi, 300. ISBN 0849392853. info
  • Aqueous polymeric coatings for pharmaceutical dosage forms. Edited by Linda A. Felton. Fourth edition. Boca Raton, FL: CRC Press, 2017, 1 online. ISBN 9781315369938. URL info
  • Handbook of Pharmaceutical Excipients. Great Britain, 2006. ISBN 1-58212-058-7. info
  • Aulton's pharmaceutics : the design and manufacture of medicines. Edited by Kevin Taylor - Michael E. Aulton. Sixth edition. [London]: Elsevier, 2022, xx, 946. ISBN 9780702081545. info
Výukové metody
1Lectures - powerpoint presentations
2 Individual lab training - practical skills
Metody hodnocení
Intermediate tests in laboratory classes
Systematic observation of the student during laboratory classes, preparation of reports following the teacher's instructions
Credit test (credit test has two parts, part 1 - pharmaceutical calculations (limit for passing 75%), part 2 - test - closed and open questions from knowledge from lectures and laboratory classes (limit for passing - 60%).
Practical testing is conducted to evaluate students' skills as part of the credit assessment.
Oral examination (study topics are available in the study materials in IS MU)
Vyučovací jazyk
Angličtina
Informace učitele
Lectures are recommended due to the lack of suitable literature. Students can study this course only after completing the course Dosage Forms and Biopharmacy I
All study materials are available in IS MU.
Další komentáře
Studijní materiály
Předmět je dovoleno ukončit i mimo zkouškové období.
Předmět je zařazen také v obdobích jaro 2020, jaro 2021, jaro 2022, jaro 2023, jaro 2024, jaro 2026.
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