FAFO2_13 Dosage Forms and Biopharmacy II

Farmaceutická fakulta
jaro 2026
Rozsah
3/6/0. 11 kr. Ukončení: zk.
Vyučováno kontaktně
Vyučující
doc. PharmDr. Aleš Franc, Ph.D. (přednášející)
doc. PharmDr. Jan Gajdziok, Ph.D. (přednášející)
doc. PharmDr. Kateřina Kubová, Ph.D. (přednášející)
PharmDr. Jakub Vysloužil, Ph.D. (přednášející)
doc. PharmDr. Aleš Franc, Ph.D. (cvičící)
doc. PharmDr. Jan Gajdziok, Ph.D. (cvičící)
doc. PharmDr. Kateřina Kubová, Ph.D. (cvičící)
PharmDr. Jakub Vysloužil, Ph.D. (cvičící)
PharmDr. Jan Elbl, Ph.D. (cvičící)
PharmDr. Hana Hořavová (cvičící)
PharmDr. Miroslava Pavelková, Ph.D. (cvičící)
PharmDr. Jiří Zeman, Ph.D. (cvičící)
Dagmar Hudecová (pomocník)
Ing. Adéla Sopoušková (pomocník)
Aneta Škrháková, DiS. (pomocník)
Garance
doc. PharmDr. Kateřina Kubová, Ph.D.
Ústav farmaceutické technologie – Ústavy – Farmaceutická fakulta
Kontaktní osoba: doc. PharmDr. Kateřina Kubová, Ph.D.
Rozvrh
Po 16. 2. až Pá 27. 2. Čt 9:15–11:45 44-247, Po 2. 3. až Pá 8. 5. Čt 9:15–11:45 18-122
  • Rozvrh seminárních/paralelních skupin:
FAFO2_13/01: Čt 13:00–14:30 18-122, Čt 14:30–18:00 18-107, J. Elbl, A. Franc, J. Gajdziok, H. Hořavová, K. Kubová, M. Pavelková, J. Vysloužil, J. Zeman
FAFO2_13/02: Čt 13:00–18:00 18-138, J. Elbl, A. Franc, J. Gajdziok, H. Hořavová, K. Kubová, M. Pavelková, J. Vysloužil, J. Zeman
Předpoklady
FAFO1_13 Dosage Forms and Biopharmacy && STUDIJNI_SKUPINA(start_before_2025) || PROGRAM(KOS)
Dosage Forms and Biopharmacy I
Students can study this course only after completing the course Dosage Forms and Biopharmacy I
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Anotace
One of the main obligatory pharmaceutical disciplines dealing with preparation, manufacturing and quality control of medicaments including technological procedures, equiment, excipients and appropriate analytical devices. It covers the influence of the application form on drug bioavailability.
Výstupy z učení
After completing the course, the student will:
- describe the theoretical aspects of semisolid dosage forms formulation and quality testing;
- describe the classification, requirements, excipients, and technological process of preparation and production of solid dosage forms, including their evaluation;
- theoretically describe the classification, requirements, excipients, technological process of preparation and production of dosage forms with controlled drug release, including their evaluation;
- know the basic aspects of semisolid and solid dosage forms about the drug bioavailability;
- describe the main conditions of GMP
- recognize selected incompatibilities in liquid and semisolid dosage forms and adjust the composition of pharmaceutical products;
- prepare semisolid (ointments, cremes, pastes, gels) and solid dosage forms (powders, granules, capsules, suppositories, vaginal globules) in pharmacy conditions
Klíčová témata
Topic of lecture

  1. Dosage forms for rectal application
  2. Dosage forms for vaginal application
  3. Granules, granulation methods. Evaluation of powders and granules
  4. Tablets, their production, and evaluation
  5. Coated products, their production and evaluation
  6. Development of new drugs from galenical perspective Pharmaceutical incompatibilities in dosage forms
  7. Pharmaceutical incompatibilities in dosage forms
  8. Multiple-unit drug delivery systems
  9. Pharmaceutical aerodispersions
  10. Transdermal preparations
  11. Good manufacturing practice in pharmacy
  12. Controlled drug release


Practical labs

  1. 19.02.2026     Semisolid dosage forms - Ointments
  2. 26.02.2026     Semisolid dosage forms - Creams
  3. 05.03.2026     Semisolid dosage forms - Pastes, Gels
  4. 12.03.2026     Rectal and vaginal dosage forms  - theoretical aspect of preparation, callibration coefficient Test - semisolid preparation.
  5. 19.03.2026     Rectal suppositories. Preparation of suppositories with known and unknown base replacement coefficient. Evaluation of suppositories.
  6. 26.03.2026     Vaginal globules, preparation by the Starke method, vaginal globules made from lipophilic bases. Preparation and evaluation. Test suppositories, vaginal balls.
  7. 02.04.2026     Technological processes in preparation of difficult prescriptions I.
  8. 09.04.2026     Technological processes in preparation of difficult prescriptions II.
  9. 16.04.2026     Catch-up week
  10. 23.04.2026     Wet and melt granulations, flowbility evaluation, disintergration/Tablets preparation by direct compression, tablet evaluation
  11. 30.04.2026     Tablets preparation by direct compression, tablet evaluation/Wet and melt granulations, flowbility evaluation, disintergration
  12. 07.05.2026     Credit test, Laboratory skills testing

Studijní zdroje a literatura
    doporučená literatura
  • European Pharmacopoeia 11
  • MAHATO, Ram I. Pharmaceutical dosage forms and drug delivery. Boca Raton, FL: CRC Press, 2007, xxxi, 300. ISBN 0849392853. info
  • Aqueous polymeric coatings for pharmaceutical dosage forms. Edited by Linda A. Felton. Fourth edition. Boca Raton, FL: CRC Press, 2017, 1 online. ISBN 9781315369938. URL info
  • Handbook of Pharmaceutical Excipients. Great Britain, 2006. ISBN 1-58212-058-7. info
  • Aulton's pharmaceutics : the design and manufacture of medicines. Edited by Kevin Taylor - Michael E. Aulton. Sixth edition. [London]: Elsevier, 2022, xx, 946. ISBN 9780702081545. info
Přístupy, postupy a metody používané ve výuce
1Lectures - powerpoint presentations
2 Individual lab training - practical skills, disscussion
Způsob ověření výstupů z učení a požadavky na ukončení
Intermediate tests in laboratory classes
Systematic observation of the student during laboratory classes, preparation of reports following the teacher's instructions
Final test (credit test has two parts, part 1 - pharmaceutical calculations (limit for passing 75%),  part 2 – test with closed and open questions from knowledge from lectures (minor) and laboratory classes (major) covering  Dosage forms and Biopharmacy II + Semisolid dosage forms (limit for passing – 60 %)
Practical testing is conducted to evaluate students' skills as part of the final assessment.
Oral examination (study topics are available in the study materials in IS MU)

Attendance at practical lessons is compulsory, missed lessons have to be compensated (max. 3, 1x unexcused absence) – catch-up week according to the schedule.

Vyučovací jazyk
Angličtina
Odkaz a informace vyučujících
Lectures are recommended due to the lack of suitable literature. Students can study this course only after completing the course Dosage Forms and Biopharmacy I
All study materials are available in IS MU.
Další komentáře
Předmět je dovoleno ukončit i mimo zkouškové období.
Předmět je zařazen také v obdobích jaro 2020, jaro 2021, jaro 2022, jaro 2023, jaro 2024, jaro 2025.
  • Statistika zápisu (nejnovější)
  • Permalink: https://is.muni.cz/predmet/pharm/jaro2026/FAFO2_13