FASC1_12 Supramolecular Pharmacy

Faculty of Pharmacy
Autumn 2025
Extent and Intensity
2/0/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
Ing. Ondřej Jurček, Ph.D. et Ph.D. (lecturer)
Guaranteed by
Ing. Ondřej Jurček, Ph.D. et Ph.D.
Department of Natural Drugs – Departments – Faculty of Pharmacy
Supplier department: Department of Natural Drugs – Departments – Faculty of Pharmacy
Timetable
Tue 8:00–9:40 45-224
Prerequisites
STUDIJNI_SKUPINA(start_before_2025) || PROGRAM(KOS)
Elemental knowledge of pharmacy, organic, inorganic, and analytical chemistry
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.

The capacity limit for the course is 24 student(s).
Current registration and enrolment status: enrolled: 5/24, only registered: 0/24
fields of study / plans the course is directly associated with
Abstract
There is an emerging interest in novel advanced drug delivery strategies and complex approaches based on knowledge obtained in supramolecular chemistry and nanoscience. The course will inform students about basic principles of supramolecular chemistry and supramolecular pharmacy and various approaches known and studied. Although the field is wide, this course sets a goal to clearly explain the basic principles and the state-of-the-art knowledge about novel advanced materials as well as to provide further opportunities for more-in-depth studies. There is an ongoing introduction of such advanced nanosized systems to clinical applications and further progress in the field is desirable and inevitable – possibly in your hands.
Learning outcomes
The student will understand the basic principles of intermolecular interactions and importance of various chemical functional groups of neutral, anionic, or cationic molecules in solid and liquid phase. The student will be able to apply the knowledge on various drug delivery systems – making a sophisticated supramolecular match between a drug and a carrier. Elemental understanding of these complex processes will also provide the student with an ability to design and choose proper drug carrier and to estimate its effectivity in drug binding, carrying, targeting, and release, or even to optimize some parameters for its better performance.
Key topics
1. Introduction to supramolecular, material chemistry, and nanoscience. Drug delivery strategies. Natural products and renewable raw materials 2. Co-crystallization and polymorphism, their description, synthesis, characterization, and applications 3. Macrocyclic compounds in drug delivery 4. Artificial anion transporters and covalent cages for pharmaceutical applications 5. Nanoparticles in drug delivery (nanocrystals, micelles, liposomes, and other) 6. Polymers and their applications 7. Gels and metallogels: components, preparation, characterization, and applications 8. Metallo-supramolecular cages: ligand design, preparation, characterization, and application 9. Porous solid materials, silicates, Metal-Organic Frameworks (MOFs), preparation, characterization, and applications 10. MOFs in medicinal applications: drug loading and delivery strategies 11. Photomedicine 12. Molecular machines
Study resources and literature
  • complemented by selected research articles with pharmaceutical relevance to selected topics
  • Selected chapters of Supramolecular Chemistry, Jonathan W. Steed, Jerry L. Atwood, ISBN: 978-1-119-58251-9, complemented by selected research articles with pharmaceutical relevance to selected topics.
Approaches, practices, and methods used in teaching
Lectures
Method of verifying learning outcomes and course completion requirements
Two absences from the course will be excused. If the absence shall exceed the allowance, a mid-term test will be required in order to continue to the second half of the course. Final written test will assess student's knowledge, where irresolute, it can be complemented by a colloquium.
Language of instruction
English
Further Comments
Study Materials
The course can also be completed outside the examination period.
The course is also listed under the following terms Autumn 2023, Autumn 2024.
  • Enrolment Statistics (recent)
  • Permalink: https://is.muni.cz/course/pharm/autumn2025/FASC1_12