BVPF0321p Pathophysiology I - lecture

Faculty of Medicine
autumn 2021
Extent and Intensity
2/0/0. 2 credit(s). Type of Completion: z (credit).
Taught online.
Teacher(s)
prof. MUDr. Kateřina Kaňková, Ph.D. (lecturer)
prof. RNDr. Monika Pávková Goldbergová, Ph.D. (lecturer)
MUDr. Michal Jurajda, Ph.D. (lecturer)
Mgr. Lukáš Pácal, Ph.D. (seminar tutor)
Věra Ježková (assistant)
Mgr. Katarína Chalásová, Ph.D. (lecturer)
Guaranteed by
prof. MUDr. Kateřina Kaňková, Ph.D.
Department of Pathophysiology - Theoretical Departments - Faculty of Medicine
Contact Person: prof. MUDr. Kateřina Kaňková, Ph.D.
Supplier department: Department of Pathophysiology - Theoretical Departments - Faculty of Medicine
Prerequisites
BKFY0222p Physiology II - lecture && BVBC0221p Biochemistry - lect. && BVAT011p Anatomy of Digestive System
Physiology, biochemistry
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Main objectives are to provide student with basic understanding of following topics: Definition of pathophysiology as a discipline - concept of health & disease - ethiology & pathogenesis - disease causes
Cell x tissue x organ - regulation of cell proliferation, diferentiation and cell death - tissue injury - regeneration - reparation - wound healing - cell cycle control - malignant transformation of the cell - metastases
Inflammation, fever, pain - innate and specific immune response - immunopathology (imunodeficiency, hyperreactivity, autoimunity)
Hypoxia - oxygen tramsport – reactive oxygen species - oxidative stress – antioxidative defence
Principles of genetics – monogennic vs. complex diseases
Homeostasis – regulation and disorders of physiologic regulations – chronobiology
Pathophysiology of endocrine system
Disorders of volume, osmotic and acid-base balance
Intermediary metabolism – metabolic regulations – energy – disorders of carbohydrate metabolism
Learning outcomes
Student will be able, after completing the course (with account of the width of the subject):
- to characterize the state of health and illness in terms of different concepts
- to distinguish the genetic determinants of disease, the influence of external factors on the occurrence of diseases, the difference between monogenic and multigenic/complex disease
- to orientate in terms: cell, cell cycle
- to characterize the term homeostasis
- to discuss external and internal factors of the disease
- to characterize basic concepts of tissue involvement and wound healing
- to explain the difference between local and systemic inflammation
- to explain the chronobiology function in medicine
- to discuss the etiopathogenesis of the most important disorders of ion equilibrium and regulation of volume and tonicity
- to define basic concepts of acid-base balance
- to evaluate the importance of abnormalities of the most important micronutrients, disorders in vitamin levels and trace elements
- to define the disorders in metabolism of carbohydrates, lipids, proteins and amino acids
- to characterize energy balance disorders
Syllabus
  • 1: Definition of pathophysiology as a discipline - concept of health & disease - ethiology & pathogenesis - internal and external disease causes
  • 2: Cell x tissue x organ - regulation of cell proliferation, diferentiation and cell death - tissue injury - regeneration - reparation - wound healing
  • 3: General signs of disease - inflammation, fever, pain - innate and specific immune response - immunopathology (imunodeficiency, hyperreactivity, autoimunity)
  • 4: Hypoxia - oxygen tramsport – reactive oxygen species - oxidative stress – antioxidative defence
  • 5: Cell cycle control - malignant transformation of the cell - metastases - tumor vs. host interaction
  • 6: Principles of genetics – monogennic vs. complex diseases
  • 7: Homeostasis – regulation and disorders of physiologic regulations – chronobiology - pathophysiology of endocrine system I - hypothalamus, hypophysis
  • 8: Pathophysiology of endocrine system II – adrenals, thyroid gland štítná žláza, parathyroid bodies, endocrinne pancreas
  • 9: Disorders of volume and osmotic balance
  • 10: Disorders of acid-base balance
  • 11: Disorders of metabolism I - carbohydrates – diabetes mellitus
  • 12: Disorders of metabolism II - lipids
  • 13: Disorders of metabolism III - purins, pyrimidins, porfyrins and hem
  • 12: Disorders of metabolism IV - micronutrients, vitamins
Literature
    recommended literature
  • KAŇKOVÁ, Kateřina, Dobroslav HÁJEK, Marcel HORKÝ, Lydie IZAKOVIČOVÁ HOLLÁ, Michal JURAJDA, Vladimír KOTALA, Jiří VÁCHA, Anna VAŠKŮ and Vladimír ZNOJIL. Patologická fyziologie pro bakalářské studijní programy (Pathophysiology for paramedical study programms). 1st ed. Brno: Masarykova univerzita v Brně, 2003. 161 pp. 1. vydání. ISBN 80-210-3112-3. info
  • KAŇKOVÁ, Kateřina. Vybrané kapitoly z patologické fyziologie: Poruchy metabolizmu a výživy. 1. vydání. Brno: Masarykova univerzita v Brně, 2005. 59 pp. ISBN 80-210-3670-2. info
Teaching methods
lecture
Assessment methods
Examination in the second semester of study. The credits are awarded for a minimum of 10 lectures. In case of non-fulfillment the student writes a written test consisting of 20 questions. Successful passing requires 60% of the right answers.
Language of instruction
Czech
Follow-Up Courses
Further comments (probably available only in Czech)
The course is taught annually.
The course is taught: every week.
General note: Studenti opakující 2. ročník nemusejí znovu absolvovat praktika, budou jim uznány zápočty, ke zkoušce mohou přijít v nejbližším zkouškovém období.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses
The course is also listed under the following terms Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, Autumn 2017, autumn 2018, autumn 2019, autumn 2020.
  • Enrolment Statistics (recent)
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