DSAMolM Advanced Molecular Medicine

Lékařská fakulta
jaro 2020
2/0/0. 3 kr. (plus 1 za k). Ukončení: k.
doc. MUDr. Mgr. Marek Mráz, Ph.D. (přednášející)
Mgr. Dáša Bohačiaková, Ph.D. (přednášející)
Mgr. Vladimír Vinarský, Ph.D. (přednášející)
Mgr. Tomáš Bárta, Ph.D. (přednášející)
doc. MUDr. Mgr. Marek Mráz, Ph.D.
Biologický ústav - Teoretická pracoviště - Lékařská fakulta
Kontaktní osoba: doc. MUDr. Mgr. Marek Mráz, Ph.D.
Dodavatelské pracoviště: Středoevropský technologický institut
Students that enroll to this course should be PhD students at Faculty of Sciences or Faculty of Medicine (any field), or in the 2nd year of their Master studies (final year) at the Faculty of Sciences, or 5th year of their studies at Faculty of Medicine (General Medicine). Students will be asked to prepare a presentation of a major scientific publication from the field that is discussed in the course. The journal articles will be assigned by the lecturer depending on the interests of the students.
Omezení zápisu do předmětu
Předmět je nabízen i studentům mimo mateřské obory.
Předmět si smí zapsat nejvýše 20 stud.
Momentální stav registrace a zápisu: zapsáno: 0/20, pouze zareg.: 0/20, pouze zareg. s předností (mateřské obory): 0/20
Mateřské obory
předmět má 70 mateřských oborů, zobrazit
Cíle předmětu
The main objective is to discuss novel concepts in CANCER BIOLOGY (approx. 2 days), BASIC MOLECULAR MECHANISMS IN THE REGULATION OF HEART BIOLOGY and VISION (approx. half day), AND REGENERATIVE MEDICINE (approx. half day). The students will present and discuss selected articles relevant for the topic. The course will be thought by several experts in the field and recent high-profile articles and discoveries will be discussed:
- orientation in the most recent advances in the pathogenesis and targeted therapy in cancer, focus on selecting therapy based on molecular aberrations, novel design of clinical trials (basket/umbrella trials, n=1 trials)
- modern technics affecting the study and therapy in oncology, especially Crispr and Next-generation sequencing (NGS), single cell analysis
- novel concepts in immunotherapy such as CAR-T cell and check-point inhibitors, and their position in oncology
- role of tumor microenvironment on the progression and therapy of diseases
- regenerative medicine of human heart and vision
- neurodegenerative disease biology, and possibilities of studies with neuronal precursors derived from embryonic stem cells, preparation of mini-brains
Výstupy z učení
Students will be exposed to the recent advances in the field of cancer biology including methodological approaches, novel concepts in the biology of heart and vision, and also regenerative medicine. They will understand the opened questions in the field, and the further directions with implications for therapy of patients. They will to learn and discuss how molecular biology contributes to disease treatment and regenerative medicine. They will have in-depth discussion with experts in the field.
  • 1. CANCER: Cancer Genomics to Targeted Therapies/Precision Cancer Medicine (NGS)
  • 2. CANCER: Emerging Methods for Functional Genomic Analysis
  • 3. CANCER: Rethinking Immunotherapeutic approaches in Cancer
  • 4. CANCER: Non-coding RNAs in Cancer
  • 5. CANCER: Microenvironment interactions in Cancer
  • 6. CANCER: Advances in Patient-Derived Xenograft Modeling
  • 7. CANCER: New Clinical Trial Design for Targeted Therapies and Use of Liquid Biopsies
  • 8. CANCER: Biologic and Clinical Significance of Intratumoral Heterogeneity
  • 9. CANCER: Impact of the Microbiome
  • 10. CANCER: Cancer Modeling with CRISPR
  • 11. CANCER: Advances in Cancer/Neo-antigen Vaccines
  • 12. CANCER: Single-Cell Analysis of the Epigenome and Transcriptome
  • 13. CANCER: Extracellular Vesicles
  • 14. CANCER: Genomic/Functional Screens to Predict Response/Resistance
  • 15. HEART: Regulation of cardiomyocyte contractility
  • 16. HEART: Molecular changes in cardiomyopathies and therapeutic interventions
  • 17. HEART: Molecular mechanisms of mechano-sensing
  • 18. HEART: Biochemical and structural changes of extracellular matrix during remodelling
  • 19. HEART: 2D and 3D in vitro models of cardiac tissue
  • 20. HEART: Regeneration of the heart
  • 21. REGENERATIVE MEDICINE: Cell reprogramming - change of cell identity
  • 22. REGENERATIVE MEDICINE: Application potential of pluripotent stem cells
  • 23. REGENERATIVE MEDICINE AND VISION: Modeling vision in vitro – retinal organoids and generation of cells for vision therapy
  • 24. REGENERATIVE MEDICINE: Modelling of neural development using pluripotent stem cells
  • 25. REGENERATIVE MEDICINE: 3D cell culture for organoids and organs-on-chip
  • 26. REGENERATIVE MEDICINE: Neuro-regeneration and mini-brains for neurodegenerative diseases in vitro
  • Presentations from the course
  • Scientific articles from the course
Výukové metody
lectures, class discussion, group projects, and presentations
Metody hodnocení
Colloquium requirements: active participation on the course, presentation of selected scientific topic/article
Vyučovací jazyk
Informace učitele
Marek Mraz, email: marek.mraz@email.cz, ceitec.cz/mrazlab
Další komentáře
Předmět je vyučován každoročně.
Výuka probíhá blokově.

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