VLBC0321c Biochemistry I

Faculty of Medicine
Autumn 2016
Extent and Intensity
0/2/0. 3 credit(s). Type of Completion: z (credit).
Ing. Martina Čarnecká, Ph.D. (seminar tutor)
doc. RNDr. Jiří Dostál, CSc. (seminar tutor)
MUDr. Lenka Gescheidtová, Ph.D. (seminar tutor)
Mgr. Jana Gregorová, Ph.D. (seminar tutor)
MUDr. Miroslava Hlaváčová, Ph.D. (seminar tutor)
MUDr. Michaela Králíková, Ph.D. (seminar tutor)
Mgr. Milena Matejovičová, Ph.D. (seminar tutor)
RNDr. Hana Paulová, CSc. (seminar tutor)
Mgr. Ondřej Peš, Ph.D. (seminar tutor)
MUDr. RNDr. Michal Řiháček (seminar tutor)
Mgr. Jiří Slanina, Ph.D. (seminar tutor)
prof. RNDr. Eva Táborská, CSc. (seminar tutor)
doc. RNDr. Josef Tomandl, Ph.D. (seminar tutor)
Mgr. Marie Tomandlová, Ph.D. (seminar tutor)
PharmDr. Katarína Kostolanská (assistant)
Lenka Nerudová (assistant)
Mgr. Lucie Novotná (assistant)
Mgr. Anna Pleskačová, Ph.D. (assistant)
Mgr. Roman Sándor (assistant)
Guaranteed by
prof. RNDr. Eva Táborská, CSc.
Department of Biochemistry - Theoretical Departments - Faculty of Medicine
Supplier department: Department of Biochemistry - Theoretical Departments - Faculty of Medicine
Timetable of Seminar Groups
VLBC0321c/01: Wed 7:30–9:10 A16/211
VLBC0321c/02: Wed 7:30–9:10 A16/211
VLBC0321c/03: Wed 7:30–9:10 A16/211, J. Gregorová
VLBC0321c/04: Wed 7:30–9:10 A16/211, J. Gregorová
VLBC0321c/05: Fri 9:20–11:00 A16/211, M. Tomandlová
VLBC0321c/06: Fri 9:20–11:00 A16/211, M. Tomandlová
VLBC0321c/07: Thu 15:20–17:00 A16/211, M. Čarnecká
VLBC0321c/08: Fri 7:30–9:10 A16/211, J. Tomandl
VLBC0321c/09: Thu 15:20–17:00 A16/211, M. Čarnecká
VLBC0321c/10: Fri 7:30–9:10 A16/211, J. Tomandl
VLBC0321c/11: Wed 16:00–17:40 A16/211, J. Slanina
VLBC0321c/12: Wed 16:00–17:40 A16/211, J. Slanina
VLBC0321c/13: Wed 14:00–15:40 A16/211, H. Paulová
VLBC0321c/14: Wed 14:00–15:40 A16/211, H. Paulová
VLBC0321c/15: Fri 7:30–9:10 A16/211, J. Dostál
VLBC0321c/16: Fri 7:30–9:10 A16/211, J. Dostál
VLBC0321c/17: Wed 12:00–13:40 A16/211, M. Králíková
VLBC0321c/18: Wed 12:00–13:40 A16/211, M. Králíková
Prerequisites (in Czech)
VLBI0222c Biology II-pract. && VLBF011c Biophysics - pract.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of the course is to obtain knowledge on essential metabolic processes on the cell level. Understanding of these proceses is a base for comprihension of metabolism on the tissue and organ level. In the introductory lessons are summarized basic terms from chemistry needed for understanding of body structure a physico-chemical processes occuring in it ((chemical composition of the body, survay of biologically important elements,water, elektrolytes, non-elektrolytes, osmotic pressure, acid-base, redox and precipitation reactions), the following lectures are focused on biochemichal pathways in cells. The graduate is acquainted with principles of acid-base, precipitation and redox reactions, role of macro- and micro elements in the body, properties and function of enzymes, is oriented in catabolic and anabolic pathways of metabolism of saccharides, lipids and proteins and their consequences.Understands the principles of cell bioenegetics.Become familiar with the funcion of cell membranes, principle of cell compartmentation and membrane transport.Has knowledge on proteosynthesis including processes replication,transcription, translation and posttranslantion modifications.Understands the relation between the structure and function of proteins. Is acquinted with function of hemoglobine in oxygen transport.Molecular bases of some diseases are introduced. The course provides the essential knowledge for future understanding of metabolism on organe and inter-organe level and its disturbances.
  • Chemical composition of human body.
  • Water, electrolytes, osmotic pressure, osmolality. pH, buffers. Structure of haemoglobin and its relationship to the function. Hb types in the blood of healthy subjects, HbCO and MetHb, abnormal Hb types. Enzymes - reaction rate, progress curve, the Michaelis plot and Km, enzyme inhibition. Coenzymes, their relationship to vitamins. Membrane structure and assembly. Transport across membranes. Metabolism of glucose: Glycolysis under anaerobic and aerobic conditions and the oxidation of pyruvate. Gluconeogenesis. Glycogenesis and glycogenolysis. Metabolism of proteins. Common features of amino acid conversion. The synthesis of urea. Nitrogen balance. Important reactions in amino acid catabolism. Biosynthesis and desaturation of fatty acids. The sources of essential fatty acids. Metabolism of triacylglycerols. Metabolism of phospholipids. Biosynthesis of eicosanoids. Peroxidation of lipids. The citric acid cycle. The respiratory chain and oxidative phosphorylation. Replication, transcription, proteosynthesis.
Teaching methods
Course is based on group discusion to the given topics. The outlines of discusion are in the recommended textbook. Complementary materials are available in section Study materials.
Assessment methods (in Czech)
Základní podmínkou je absolvování všech seminářů/cvičení. V průběhu semestru se v semináři píšou 4 průběžné testy. Pokud z průběžných testů získá student nejméně 42 bodů, je mu udělen zápočet bez povinnosti psát zápočtový test. Ostatní studenti píší zápočtový test, který má 30 otázek. Podmínkou pro udělení zápočtu je 14 bodů. Zápočtový test je možno psát po nahrazení veškeré zameškané výuky. Studenti, kteří v zápočtovém týdnu nesplní podmínky zápočtového testu, mají možnost jej jedenkrát opakovat.
Language of instruction
Further Comments
The course is taught annually.
Listed among pre-requisites of other courses
The course is also listed under the following terms Autumn 2017, autumn 2018, autumn 2019, autumn 2020.
  • Enrolment Statistics (Autumn 2016, recent)
  • Permalink: https://is.muni.cz/course/med/autumn2016/VLBC0321c