CS

LF:VLFA0621c Pharmacology I - p - Course Information

VLFA0621c Pharmacology I - practice

Faculty of Medicine
Spring 2017
Extent and Intensity
0/3/0. 5 credit(s). Type of Completion: z (credit).
Teacher(s)
doc. MUDr. Regina Demlová, Ph.D. (lecturer)
doc. PharmDr. Jan Juřica, Ph.D. (lecturer)
MUDr. Jana Nováková, Ph.D. (lecturer)
MUDr. Jana Pistovčáková, Ph.D. (lecturer)
PharmDr. Ondřej Zendulka, Ph.D. (lecturer)
doc. PharmDr. Jana Rudá, Ph.D. (lecturer)
Mgr. MVDr. Leoš Landa, Ph.D. (lecturer)
MVDr. Zuzana Babinská, Ph.D. (lecturer)
Mgr. Barbora Říhová, Ph.D. (lecturer)
doc. RNDr. Ladislava Bartošová, Ph.D. (seminar tutor)
Mgr. Gabriela Dovrtělová, Ph.D. (seminar tutor)
MVDr. Eva Dražanová (seminar tutor)
MVDr. Eva Gospošová (seminar tutor)
Mgr. MVDr. Leoš Landa, Ph.D. (seminar tutor)
Mgr. Matej Ľupták (seminar tutor)
Mgr. Jana Merhautová, Ph.D. (seminar tutor)
Mgr. Kristýna Nosková (seminar tutor)
PharmDr. Adriána Papiež, Ph.D. (seminar tutor)
MUDr. Petra Řiháčková, MBA (seminar tutor)
PharmDr. Lenka Součková, Ph.D. (seminar tutor)
Mgr. Markéta Strakošová (seminar tutor)
Mgr. Tibor Štark (seminar tutor)
MUDr. Jana Vinklerová, Ph.D. (seminar tutor)
Renata Bláblová (assistant)
Supervisor
doc. MUDr. Regina Demlová, Ph.D.
Department of Pharmacology - Theoretical Departments - Faculty of Medicine
Contact Person: doc. MUDr. Regina Demlová, Ph.D.
Supplier department: Department of Pharmacology - Theoretical Departments - Faculty of Medicine
Timetable of Seminar Groups
VLFA0621c/01: Wed 7:30–10:00 A19/231
VLFA0621c/02: Wed 7:30–10:00 A19/231, J. Rudá
VLFA0621c/03: Wed 10:20–12:50 A19/231
VLFA0621c/04: Wed 10:20–12:50 A19/231, J. Juřica
VLFA0621c/05: Fri 8:00–10:30 A19/231
VLFA0621c/06: Fri 8:00–10:30 A19/231
VLFA0621c/07: Fri 10:45–13:15 A19/231
VLFA0621c/08: Fri 10:45–13:15 A19/231, J. Pistovčáková
VLFA0621c/09: Mon 8:00–10:30 A19/231
VLFA0621c/10: Mon 8:00–10:30 A19/231
VLFA0621c/11: Mon 10:45–13:15 A19/231
VLFA0621c/12: Mon 10:45–13:15 A19/231
VLFA0621c/13: Tue 8:00–10:30 A19/231
VLFA0621c/14: Tue 8:00–10:30 A19/231
VLFA0621c/15: Thu 10:45–13:15 A19/231
VLFA0621c/16: Thu 10:45–13:15 A19/231, J. Pistovčáková
VLFA0621c/17: Tue 10:45–13:15 A19/231, O. Zendulka
VLFA0621c/18: Tue 10:45–13:15 A19/231, B. Říhová
VLFA0621c/30: Tue 13:30–16:00 A19/231, O. Zendulka
VLFA0621c/31: Wed 13:30–16:00 A19/326, J. Rudá
VLFA0621c/32: Thu 13:30–16:00 A19/326
VLFA0621c/33: Tue 13:30–16:00 A19/326
VLFA0621c/34: Wed 13:30–16:00 A19/231, J. Juřica
VLFA0621c/35: Thu 13:30–16:00 A19/326, J. Pistovčáková
Prerequisites (in Czech)
VSPF0521c Pathophysiol. I - practice. && VSPA0521c Pathology - practicals
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
Fields of study the course is directly associated with
Course objectives
On completion of the course the student will be able to use formally correct terminology belonging to the valid Pharmacopoea in prescription and making of drug dosage forms of both individually prepared and bulk preparations. The student should be able to understand principles of "pharmacological thinking" for choosing a drug, dosing regimen, pharmacokinetic parameter calculation, differences in administration routes and specifics of pediatric and geriatric pharmacotherapy including possible impact of drug-drug interactions.
Learning outcomes
On completion of the course the student will be able to use formally correct terminology belonging to the valid Pharmacopoea in prescription and making of drug dosage forms of both individually prepared and bulk preparations. The student should be able to understand principles of "pharmacological thinking" for choosing a drug, dosing regimen, pharmacokinetic parameter calculation, differences in administration routes and specifics of pediatric and geriatric pharmacotherapy including possible impact of drug-drug interactions.
Syllabus
  • Pharmacology - practical courses

    Spring semester 2017

  • 1st week (20.2.-24.2.)
  • Topic: INTRODUCTION, TERMINOLOGY, DOSES, PHARMACOLOGICAL CALCULATIONS.
  • Course content: Organisation of practical courses and lectures. Recommended textbooks. Pharmacology – definition, basic terminology, subspecializations. Experimental pharmaology. Drug nomenclature, type of doses. Pharmacopoea. Drug dosology in paediatrics.
  • Getting ready for next lesson: Repetition of latin terminology and pharmacological calculations.
  • Selfstudy: Prescription abbreviations.
  • 2nd week (27.2.-2.3.)
  • Topic: GENERAL RULES OF THE DRUG PRESCRIPTION
  • Course content: Medical prescription: Rules of the drug prescription. Prescription of individualy prepared and ready made preparations. Legislation of drug prescription. Work with various handbooks and databases (SÚKL database, Pharmindex, DynaMed.). Prescription of narcotic and psychotropic agents.
  • Getting ready for the next lesson: Repetition of general rules of drug prescription + abbreviations.
  • 3rd week (6.3.-10.3.)
  • Topic: FLUID DRUG DOSAGE FORMS FOR THE EXTERNAL USE, ORAL AND PARENTERAL USE. GASEOUS DRUG DOSAGE FORMS.
  • Course content: : Application and rinse solutions; eye, ear and nose lotions, suspensions - composition and prescription. Solutions for oral administration, drops, aromatic waters, tinctures. Terminology, classification, prescription.
  • 4th week (13.3.-17.3.)
  • Topic: SOLID DRUG DOSAGE FORMS. SOFT AND MELTING DRUG DOSAGE FORMS.
  • Course content: Powders for external and internal use, capsules, tablets, teas; suppositories. Ointments, creams, pastes, plasters. Terminology, classification, prescription. Getting ready for the next lesson: Repetition of general rules of the drug prescription.
  • 5th week (20.3.-24.3.)
  • Topic: INTRODUCTION TO THE PHARMACOKINETICS.
  • Course content: Basic pharmacokinetic processes and parameters. One- and two-compartment kinetic models. Kinetics of the intravascular and extravascular drug administration. Kinetics of single and repeated drug administration. Getting ready for the next lesson: Pharmacokinetic calculations.
  • TEST Lessons 1-4
  • 6th week (27.3.-31.3.)
  • Topic: CASE REPORTS I - PHARMACOKINETIC INTERACTIONS. THERAPEUTIC DRUG MONITORING.
  • Course content: Computer techniques in pharmacokinetics. Therapeutic drug monitoring. Calculations of the basic pharmacokinetic parameters: Work with PC: Demonstration of software MW PHARM; Interactions of pharmacokinetic type.
  • Getting ready for the next lesson: Physiology of ANS.
  • 7th week (3.4.-7.4.)
  • Topic: PHARMACOLOGY OF THE SYMPATHETIC NERVOUS SYSTEM I. SYMPATHOMIMETICS.
  • Course content: Receptor theory, neurotransmission in PNS. Therapeutic use of sympathomimetics.
  • TEST Lessons 2-6
  • 8th week (10.4.-14.4.)
  • Topic: PHARMACOLOGY OF THE AUTONOMIC NERVOUS SYSTEM II. SYMPATHOLYTICS
  • Course content: Therapeutic use of sympatholytics.
  • 9th week (17.4.-21.4.)
  • Topic: PHARMACOLOGY OF THE SYMPATHETIC NERVOUS SYSTEM III. CHOLINERGIC DRUGS.
  • Course content: Therapeutic use of cholinergic drugs.
  • Getting ready for the next lesson: Pathophysiology of ulcer disease and vomitus.
  • 10th week (24.4.-28.4.)
  • Topic: PHARMACOLOGY OF GASTRODUODENAL ULCER DISEASE, PROKINETICS, ANTIEMETICS.
  • Course content: Classification, mechanisms of action and clinical use of drugs in therapy of peptic ulcer and vomiting.
  • Getting ready for the next lesson: Repetition of physiology of adrenal cortex hormones, repetition of pathophysiology of disorders caused by hyperproduction or insufficiency of adrenal cortex hormones.
  • 11th week (1.5.-5.5.)
  • Topic: GLUCOCORTICOIDS.
  • Course content: Physiology and pathophysiology of adrenal cortex hormones. Natural and synthetic adrenocorticosteroids, steroid receptors, mechanism of action, pharmacological use and side effects. Examples of ready-made drug preparations.
  • Getting ready for the next lesson: Repetition of physiology and biochemistry of thyroidal and sex hormones.
  • TEST Lessons 7-10
  • 12th week (8.5.-12.5.)
  • Topic: PHARMACOLOGY OF ENDOCRINE SYSTEM.
  • Course content: Endocrine therapy, hormone replacement therapy, hormonal contraceptive drugs, thyroid hormones.
  • Getting ready for next lesson: Repetition of pathophysiology of diabetes mellitus.
  • 13th week (15.5.-19.5.)
  • Topic: ANTIDIABETIC DRUGS.
  • Course content: Therapy of type 1 and 2. DM. Insulines. Peroral antidiabetics. Examples of ready-made drug preparations.
  • TEST Lessons 11-12
  • 14th week (22.5.-26.5.)
  • Topic: PHARMACOLOGY OF MEDICINAL PLANTS.
  • Course content: History, classification and chemistry of herbal drugs, their practical medicinal use. Demonstration and tasting of selected types of plant products (teas, macerates). Toxic herbs. Demonstration of selected drug forms and raw materials used for their preparation.
  • CREDITS.
  • 15th week (31.5.)
  • Topic: EXCURSION TO THE CENTRE OF MEDICINAL PLANTS.
  • ATTENDANCE VOLUNTARY
Literature
    required literature
  • RANG, H. P. Rang & Dale's pharmacology. 8th ed. [Edinburgh]: Churchill Livingstone, 2016. xv, 760. ISBN 9780702053627. info
  • http://portal.med.muni.cz/clanek-611-zaklady-specialni-receptury-lecivych-pripravku.html
  • For English speaking students: Practicals in Pharmacology http://portal.med.muni.cz/discipline-13-pharmacology
    recommended literature
  • LINCOVÁ, Dagmar and Hassan FARGHALI. Základní a aplikovaná farmakologie. 2., dopl. a přeprac. vyd. Praha: Galén, 2007. xxiv, 672. ISBN 9788072623730. info
  • http://portal.med.muni.cz/clanek-621-zivotni-cyklus-leciv-klinicke-hodnoceni-a-registrace-lecivych-pripravku-farmakovigilance-a-stanovovani-cen-a-uhrad-leciv.html
  • http://portal.med.muni.cz/clanek-461-farmakovigilance-a-propagace-leciv.html
  • http://elportal.cz/publikace/kazuistiky-farmakologie
  • http://portal.med.muni.cz/clanek-649-zaklady-farmakoekonomiky.html
  • Pharmaceutical practice. Edited by Judith A. Rees - Ian Smith - Jennie Watson. 5th ed. Edinburgh: Churchill Livingstone Elsevier, 2014. xvii, 552. ISBN 9780702051432. info
    not specified
  • http://portal.med.muni.cz/clanek-553-zaklady-receptury-lecivych-pripravku.html
  • Český lékopis 2009. Praha: Grada, 2011. 1 DVD. ISBN 8594049240180. info
  • WHALEN, Karen. Lippincott illustrated reviews : Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins, 2015. xi, 664. ISBN 9781451191776. info
  • DOSTÁLEK, Miroslav, Jan JUŘICA, Eva JANOŠTÍKOVÁ and Lucia ZAHRADNÍKOVÁ. Farmakokinetika (Pharmacokinetics). ČR: Grada, 2006. 220 pp. Farmacie a farmakologie. ISBN 80-247-1464-7. info
  • Waller, Derek - Renwick, Andrew G. - Hillier, Keith. Medical pharmacology and therapeutics. 3rd ed. New York : Elsevier Saunders, 2009. ix, 744 p. ISBN 0-7020-2991-2.
  • Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
  • http://portal.med.muni.cz/clanek-652-behavioralni-metody-v-neuropsychofarmakologii.html
  • http://portal.med.muni.cz/clanek-367-vyzkum-novych-leciv-od-zrodu-k-registraci.html
  • http://portal.med.muni.cz/clanek-644-farmakologie-pro-studenty-bakalarskych-oboru-na-lf-mu.html
Teaching methods
Practicals, the teaching process of include theoretical setting up as well as practical training of knowledge and skills stated in Syllabus. Included are also individual work with specific pharmacological softwares and homeworks on the selected topics, presented and discussed afterward in class.
Assessment methods
The participation in practicals is obligatory and registered. To get a credits a student has to pass 3 written tests: a) on drug prescription (assessed individually by the teacher), b)3 x multiple-choice test on knowledge of topics taught (score higher than 60% of maximum to pass, 8 pts. out of 15).
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught annually.
Listed among pre-requisites of other courses
The course is also listed under the following terms Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016.
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