VLFA07212p Farmakologie I - přednáška

Faculty of Medicine
autumn 2020
Extent and Intensity
2/0/0. 1 credit(s). Type of Completion: k (colloquium).
Teacher(s)
doc. MUDr. Regina Demlová, Ph.D. (lecturer)
doc. PharmDr. Jan Juřica, Ph.D. (lecturer)
Mgr. Petra Amchová, Ph.D. (lecturer)
doc. RNDr. Ladislava Bartošová, Ph.D. (lecturer)
MUDr. Lea Janáková, Ph.D. (lecturer)
doc. Mgr. MVDr. Leoš Landa, Ph.D. (lecturer)
Mgr. Jana Merhautová, Ph.D. (lecturer)
Mgr. Kristýna Nosková, Ph.D. (lecturer)
MUDr. Jana Nováková, Ph.D. (lecturer)
MUDr. Jana Pistovčáková, Ph.D. (lecturer)
doc. PharmDr. Jana Rudá, Ph.D. (lecturer)
PharmDr. Jitka Rychlíčková, Ph.D. (lecturer)
Mgr. Barbora Říhová, Ph.D. (lecturer)
PharmDr. Lenka Součková, Ph.D. (lecturer)
prof. MUDr. Dalibor Valík, Ph.D., DABCC (lecturer)
doc. RNDr. Lenka Zdražilová Dubská, Ph.D. (lecturer)
doc. PharmDr. Ondřej Zendulka, Ph.D. (lecturer)
Róbert Balog (assistant)
Renata Bláblová (assistant)
Agnesa Gabuľová (assistant)
Květoslava Sedlářová (assistant)
Filip Šiška (assistant)
Ing. Lenka Hořavová (alternate examiner)
PharmDr. Katarína Kostolanská (alternate examiner)
Mgr. Kateřina Nebeská (alternate examiner)
PharmDr. Eva Vohlídalová (alternate examiner)
Guaranteed by
doc. MUDr. Regina Demlová, Ph.D.
Department of Pharmacology - Theoretical Departments - Faculty of Medicine
Contact Person: doc. PharmDr. Ondřej Zendulka, Ph.D.
Supplier department: Department of Pharmacology - Theoretical Departments - Faculty of Medicine
Prerequisites (in Czech)
VLPF0622p Pathophysiol. II - lect. && VLPA0622c Pathology - practice
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aims of the course are:
to explain the basic pharmacodynamic and pharmacokinetic processes and principles
to explain the basic principles of therapy of intoxications
to describe the factors that influence the drug effect
Learning outcomes
Student after the course:
knows basic pharmacodynamic principles
knowns basic pharmacokinetic principles
knows basic factors that influence the effect of drugs
is able to suggest therapeutic measures in case of drug intoxication
Syllabus
  • VLFA07212p - Pharmacology I - Lectures

    General medicine

    Autumn semester 2019

  • 17. 9. 2019 18:00-19:40, UKB A11/114
  • PHARMACOLOGY AND ITS SUB-BRANCHES
  • Course content: Definition of pharmacology and its sub-branches of pharmacology. Drug, medical product – basic pharmacological terminology. Sources of research and development of new drugs. Principles of correct drug use – types of pharmacotherapy and rational pharmacotherapy.
  • 24. 9. 2019 18:00-19:40, UKB A11/114
  • OVERVIEW OF DRUG DOSAGE FORMS
  • Course content: Classification and overview of drug dosage forms for ready-made production and individual preparation, advantages and disadvantages of the particular types of drug dosage forms in clinical use, typical auxiliary substances (excipients). Drug dosage forms with controlled release.
  • 1. 10. 2019 18:00-19:40, UKB A11/114
  • ROUTES OF DRUG ADMINISTRATION
  • Course content: Classification of routes of administration, description of the individual ways with examples of drugs. Overview of innovative administration routes.
  • 8. 10. 2019 18:00-19:40, UKB A11/114
  • PHARMACOKINETICS I
  • Course content: General principles of drug's fate in the organism. Overview of the basic pharmacokinetic processes and parameters.
  • 15. 10. 2019 18:00-19:40, UKB A11/114
  • PHARMACOKINETICS II
  • Course content: Single, continual and repeated drug administration. Principles of therapeutic drug monitoring. Compartment models. Fundamentals of population pharmacokinetics.
  • 22. 10. 2019 18:00-19:40, UKB A11/114
  • PHARMACODYNAMICS
  • Course content: Mechanisms of drugs effects – classification, examples. Receptor theory – types of ligands and receptors. Change in drug effect after repeated administration.
  • 29. 10. 2019 18:00-19:40, UKB A11/114
  • PHARMACOVIGILANCE AND DRUG'S SAFETY
  • Course content: Adverse effects of drugs - classification and characteristics. Pharmacovigilance in clinical research and practice. Therapeutic index, therapeutic range. Drug anamnesis, polypharmacy and introduction to drug interactions.
  • 5. 11. 2019 18:00-19:40, UKB A11/114
  • FACTORS AFFECTING DRUG'S EFFECTS
  • Course content: Classification, overview and examples of factors affecting drug effects. Fundamentals of pharmacogenetics.
  • 12. 11. 2019 18:00-19:40, UKB A11/114
  • PHARMACOLOGY OF AUTONOMIC NERVOUS SYSTEM
  • Course content: Overview of pharmacology of sympathetic and parasympathetic nervous system – neurotransmission, receptors. Basic indications of substances affecting ANS.
  • 19. 11. 2019 18:00-19:40, UKB A11/114
  • BASIC PRINCIPLES OF BIOLOGICAL THERAPY, BIOLOGICAL THERAPY OF RHEUMATOID AND GOUTY ARTHRITIS
  • Course content: Definition of terms, advantages and disadvantages of biological treatment in comparison to conventional therapy. Fundamental principles of technologies used in production of biological medical products, their classification and examples of clinical use. Overview of biological drugs used in rheumatoid and gouty arthritis.
  • 26. 11. 2019 18:00-19:40, UKB A11/114
  • ANALGESIC DRUGS
  • Course content: Classification of analgesic drugs. Basic pharmacological characteristics and examples of use of opioid analgesics, non-steroidal anti-inflammatory drugs and analgesic-antipyretic drugs.
  • 3. 12. 2019 18:00-19:40, UKB A11/114
  • GENERAL AND LOCAL ANAESTHETIC AGENTS
  • Course content: Classification and pharmacological characteristics of general and local anaesthetic drugs.
  • 10. 12. 2019 18:00-19:40, UKB A11/114
  • PHARMACOTHERAPY OF DIABETES MELLITUS
  • Course content: Insulins and anti-diabetic drugs – classification and basic pharmacological characteristics.
  • 17. 12. 2019 18:00-19:40, UKB A11/114
  • PHARMACOLOGY OF SEX HORMONES
  • Course content: Analogues and antagonists FSH, LH. Oestrogens, antioestrogens, gestagens, antigestagens, androgens, antiandrogens basic pharmacological characteristics (classification, basic substances, therapeutic indications/contraindications, adverse effects).
  • 7. 1. 2020 18:00-19:40, UKB A11/114
  • IMMUNOPHARMACOLOGY - IMMUNOSUPRESSIVES AND IMMUNOMODULATORS, BIOLOGICS
  • Course content: Overview of drugs affecting immune system - classification, therapeutic use, basic pharmacological characteristics.
Literature
    required literature
  • RANG, H. P. Rang & Dale's pharmacology. 8th ed. [Edinburgh]: Churchill Livingstone, 2016. xv, 760. ISBN 9780702053627. info
  • http://search.ebscohost.com/login.aspx?direct=true&db=nlebk&AN=1160493&lang=cs&site=ehost-live
  • Životní cyklus léčiv, Demlová a kol., 2014, http://portal.med.muni.cz/clanek-621-zivotni-cyklus-leciv-klinicke-hodnoceni-a-registrace-lecivych-pripravku-farmakovigilance-a-stanovovani-cen-a-uhrad-leciv.html
    recommended literature
  • https://portal.med.muni.cz/disciplina-13-farmakologie
  • Landa Leoš, Jan Juřica, Kristýna Nosková, Ondřej Zendulka: Vybrané kapitoly z obecné farmakologie pro studenty všeobecného a zubního lékařství na LF MU. Multimediální podpora výuky klinických a zdravotnických oborů :: Portál Lékařské fakulty Masarykovy
  • Základy farmakoekonomiky, Říhová a kol, 2016, http://portal.med.muni.cz/clanek-649-zaklady-farmakoekonomiky.html
  • Soubor kazuistik z farmakologie, Zendulka a kol., 2016 http://elportal.cz/publikace/kazuistiky-farmakologie
  • Základy speciální receptury léčivých přípravků, Juřica a kol., 2014, http://portal.med.muni.cz/clanek-611-zaklady-specialni-receptury-lecivych-pripravku.html
  • Atlas léčivých rostlin, https://is.muni.cz/auth/do/med/el/lecive_rostliny/atlas.html
  • Základy receptury léčivých přípravků. Nováková a kol., 2010, http://portal.med.muni.cz/clanek-553-zaklady-receptury-lecivych-pripravku.html
  • ŠVIHOVEC, Jan a kol. Farmakologie, Praha: Grada, 2018. ISBN 978-80-247-5558-8. www.grada.cz/farmakologie-(1)-8687
  • LINCOVÁ, Dagmar and Hassan FARGHALI. Základní a aplikovaná farmakologie. 2., dopl. a přeprac. vyd. Praha: Galén, 2007. xxiv, 672. ISBN 9788072623730. info
    not specified
  • Farmakovigilance a propagace léčiv, Vršková a kol., 2007, http://portal.med.muni.cz/clanek-461-farmakovigilance-a-propagace-leciv.html
  • Výzkum nových léčiv od zrodu k registraci, Starobová a kol., 2006, http://portal.med.muni.cz/clanek-367-vyzkum-novych-leciv-od-zrodu-k-registraci.html
  • Farmakologie pro studenty bakalářských oborů na LF MU, Máchalová a kol., 2015, http://portal.med.muni.cz/clanek-644-farmakologie-pro-studenty-bakalarskych-oboru-na-lf-mu.html
  • MARTÍNKOVÁ, Jiřina. Farmakologie pro studenty zdravotnických oborů. 2., zcela přeprac. a doplň. Praha: Grada, 2014. ISBN 9788024713564. info
  • DOSTÁLEK, Miroslav, Jan JUŘICA, Eva JANOŠTÍKOVÁ and Lucia ZAHRADNÍKOVÁ. Farmakokinetika (Pharmacokinetics). ČR: Grada, 2006. 220 pp. Farmacie a farmakologie. ISBN 80-247-1464-7. info
  • WHALEN, Karen. Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins, 2015. xi, 664. ISBN 9781451191776. info
  • Waller, Derek - Renwick, Andrew G. - Hillier, Keith. Medical pharmacology and therapeutics. 3rd ed. New York : Elsevier Saunders, 2009. ix, 744 p. ISBN 0-7020-2991-2.
  • Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
  • Pharmaceutical practice. Edited by Judith A. Rees - Ian Smith - Jennie Watson. 5th ed. Edinburgh: Churchill Livingstone Elsevier, 2014. xvii, 552. ISBN 9780702051432. info
  • Practicals in Pharmacology, 2009, Náhradní obsah: http://portal.med.muni.cz/article-491-practicals-in-pharmacology.html
Teaching methods
lectures, presentations by professionals in the sectors
Assessment methods
Colloquium - written ROPOT test: 40 multiple-choice questions with 3 to 5 options of asnwers. The number of correct answers is given.

Student gets 2 points for each completely correct answer, i.e. maximum 80 points for the whole multiple-choice test. Time limit: 60 min. The MCQ test can be repeated only twice.

To pass the colloquium successfully the student has to obtain at least 40 points.
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught annually.
The course is taught: every week.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses
Teacher's information

General pharmacology:

1. Pharmacology, sub-branches, origin of drugs, drug names.

2. Types of pharmacotherapy, rules of rational and safe phramacotherapy. The question of drug misuse.

3. Preclinical and clinical trials, stages.

4. Basic legislation related to drug use, Sources of information on drugs and medicinal products.

5. Solid and gaseous pharmaceutical drug dosage forms - overview and their influence on pharmacokinetics and pharmacodynamics.

6. Semi-solid and liquid pharmaceutical drug dosage forms - overview and their influence on pharmacokinetics and pharmacodynamics.

7. Routes of drug administration – overview, characteristics.

8. Drug absorption, presystemic elimination, drug bioavailability.

9. Drug distribution, volume of distribution, redistribution. General principles of drug movement through the body.

10. Drug elimination, processes of the first and zero order, drug accummulation.

11. Drug biotransformation – stages, examples.

12. Drug excretion (ways of excretion, possibilities of their influence).

13. Therapeutic monitoring of drugs (TDM).

14. Pharmacokinetics of single, repeated and continual drug administration.

15. Modes of drug action

16. Inhibition and induction of enzymes in pharmacokinetics and pharmacodynamics of drugs – examples.

17. Synergism and antagonism in drug effect (pharmacokinetics, pharmacodynamics).

18. Dose – response curves, types of doses, drug anamnesis, patient‘s adherence.

19. Adverse drug reactions (types, categories, examples).

20. Pharmacovigilance, drug safety.

21. Primary resistance of the patient to the treatment. Influence of repeated administration on drug efficacy - examples of tolerance and tachyphylaxis.

22. Factors influencing the drug effect – examples.

23. Pharmacotherapy in elderly, the influence of co-morbidities on drug effect, polypharmacy.

24. Pharmacotherapy in pediatric population, in breastfeeding women. Drugs influencing breast feeding.

25. Pharmacotherapy in pregnancy, drug teratogenicity.

26. Pharmacogenetics, influence of genetic polymorfisms on pharmacokinetics and pharmacodynamics of drugs.

27. Drug interactions - overview, examples.

28. Principles of biological treatment – classification, technology, examples of clinical use.

Special pharmacology:

1. Sympathomimetics - overview of single classes and their indications, examples of drugs

2. Sympatholytics - overview of single classes and their indications, examples of drugs

3. Cholinomimetics

4. Cholinolytics

5. Antispasmodics - GIT + UGT.

6. Glucocorticoids

7. Immunostimulants + immunosuppressants (except glucocorticoids)

8. Antidiabetics (except insulines)

9. Insulins

10. Sex hormones - contraception and HRT

11. Drugs targeting H-P axis and their indications (except contraception and HRT)

12. Uterotonics and tocolytics

13. Opioid analgesics

14. NSAIDs, non-opioid analgesics, antimigraine agents

15. Antiuratics, antirheumatics incl. DMARDs

16. General anesthetics

17. Local anesthetics

18. Muscle relaxants

19. Antipsychotics

20. Drugs of neurogenerative diseases (Parkinson’s disease; dementia)

21. Anticonvulsants

22. Nootropics, cognitives

23. Hypnosedatives, anxiolytics

24. Antidepressants - iMAO+SSRI+NDRI

25. Antidepressants - tricyclic, NASSA, MASSA, SARI, SNRI, NARI, SMS

26. Psychotomimetics, drugs used in ADHD

27. Antiasthmatics, drugs used in COPD

28. Antitussives, mucoactive drugs

29. H1 antihistamines

30. Hypolipidemics, anti-obesity drugs

31. Antihypertensives – drugs targeting RAAS

32. Antihypertensives – diuretics and aldosterone antagonists

33. Antihypertensives beta blockers + central antihypertensives

34. Antihypertensives - calcium channel blockers, α1 lytics

35. Antiangial agents

36. Antiarrhythmics

37. Drugs used in heart failure

38. Antiplatelet agents

39. Fibrinolytics, antifibrinolytics

40. Anticoagulants

41. Antianemics, hemostatics

42. Aminoglycosides

43. Principles of antibacterial therapy – overview, modes of action, resistance, MIC, MBC

44. Lincosamides, glycopeptides, polymyxins

45. Tetracyclines + related ATBs, amphenicoles

46. Cephalosporines, monobactams

47. Penicillins, carbapenems

48. Sulphonamides, nitrofurans and nitroimidazoles

49. Macrolides and related ATBs

50. Quinolones, antituberculotics

51. Antimycotics

52. Dermatologics – overview of classes, drugs and effects

53. Antivirotics

54. Antiemetic drugs, prokinetics, antivertigo drugs

55. Laxatives, antidiarrhoics, drugs of infectious diarrhoeas

56. Antiulcer agents, hepatoprotectives and drugs influencing the production and excretion of bile

57. Alkylating cytostatics and other drugs aiming on DNA in oncology

58. Biological treatment of autoimmune diseases

59. Targeted treatment in oncology

60. Antimetabolites + hormonal therapy in oncology

61. Drugs causing addiction

62. Drugs used in the treatment of addiction

63. General principles of drug poisoning, specific antidotes and their mechanisms of action

64. Drugs for inflammatory bowel disease

65. Drugs used in erectile dysfunction and BHP

66. Drugs used in osteoporosis, pharmacology of thyroid gland

67. Vitamins

68. Antiglaucomatics and cycloplegics

„Essential drugs“

1. adrenalin/noradrenalin

2. dobutamine

3. ephedrine/pseudoephedrine

4. phenylephrine

5. oxymetazoline

6. methyldopa

7. salbutamol

8. doxazosin

9. metoprolol

10. timolol

11. atropin

12. butylscopolamine

13. fenpiverine/pitofenon

14. pilocarpine

15. rivastigmine

16. physostigmine

17. solifenacin

18. dexametasone

19. prednisone

20. cyclosporine

21. interferons

22. methotrexate

23. metformin

24. glimepiride

25. sitagliptin

26. insulin lispro

27. insulin glargine

28. ethinylestradiol

29. cyproterone

30. tibolone

31. tamoxifen

32. hexoprenaline

33. oxytocin

34. levonorgestrel

35. paracetamol/ASA

36. ibuprofen/diclofenac

37. indometacin

38. nimesulide/meloxicam

39. buprenorphine

40. morphine/naloxone

41. sufentanil

42. tramadol

43. metamizole

44. allopurinol

45. sumatriptan

46. desflurane

47. propofol

48. ketamine

49. procaine/lidocaine

50. suxamethonium

51. prilocaine

52. haloperidol

53. olanzapine

54. aripiprazole

55. levodopa/carbidopa

56. diazepam

57. buspirone

58. piracetam/pyritinol

59. gabapentin/pregabalin

60. carbamazepine

61. valproic acid

62. zolpidem

63. midazolam

64. escitalopram

65. amitriptyline

66. mirtazapine

67. lithium

68. methylphenidate

69. acetylcysteine

70. codeine

71. butamirate

72. ipratropium-bromide

73. bisulepine/cetirizine

74. atorvastatine

75. fenofibrate

76. ezetimibe

77. isosorbid dinitrate/nitroglycerin

78. hydrochlorothiazide/indapamide

79. furosemid

80. spironolactone

81. amlodipin

82. perindopril

83. telmisartan

84. warfarin

85. enoxaparin

86. clopidogrel

87. dabigatran

88. rivaroxaban

89. alteplase

90. digoxin

91. amiodarone

92. verapamil

93. levosimendan

94. doxycycline

95. co-amoxicillin

96. phenoxymethylpenicillin

97. piperacillin

98. meropenem

99. cefuroxim

100. cotrimoxazol

101. clarithromycin

102. azithromycin

103. gentamicin

104. ciprofloxacin

105. vancomycin

106. rifampicin

107. terbinafine

108. caspofungin

109. amphotericin B

110. fluconazole

111. acyclovir

112. zidovudine

113. isotretinoin

114. salicylic acid

115. ondansetron

116. moxastine

117. pantoprazol

118. famotidin

119. lactulose

120. aprepitant

121. metoclopramid

122. loperamide

123. betahistine

124. cinnarizine

125. cyclophosphamide

126. methotrexate

127. 5-fluorouracil

128. paclitaxel

129. doxorubicin

130. cisplatin

131. trastuzumab

132. imatinib

133. interferon alfa

134. nivolumab

135. methadone

136. buprenorphine

137. nalmefene

138. naltrexone

139. finasteride

140. sildenafil

141. ibandronic acid

The course is also listed under the following terms Autumn 2017, autumn 2018, autumn 2019.
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