LF:ZLFA0621p Pharmacology I - lect. - Course Information
ZLFA0621p Pharmacology I - lectureFaculty of Medicine
- Extent and Intensity
- 2/0/0. 0 credit(s). Type of Completion: -.
- doc. MUDr. Regina Demlová, Ph.D. (lecturer)
prof. MUDr. Alexandra Šulcová, CSc. (lecturer)
Ing. Pavel Musil (lecturer)
doc. PharmDr. Jan Juřica, Ph.D. (lecturer)
MUDr. Jana Nováková, Ph.D. (lecturer)
MUDr. Jana Pistovčáková, Ph.D. (lecturer)
doc. PharmDr. Ondřej Zendulka, Ph.D. (lecturer)
doc. PharmDr. Jana Rudá, Ph.D. (lecturer)
Mgr. Barbora Říhová, Ph.D. (lecturer)
MUDr. Mgr. Karel Šlais, Ph.D. (lecturer)
Mgr. Petra Amchová, Ph.D. (seminar tutor)
MVDr. Zuzana Babinská, Ph.D. (seminar tutor)
Mgr. Jana Kubátová, Ph.D. (seminar tutor)
MUDr. Alena Máchalová, Ph.D. (seminar tutor)
Mgr. Michaela Sabová, Ph.D. (seminar tutor)
PharmDr. Irena Sehnalová, Ph.D. (seminar tutor)
MVDr. Jakub Šmíd (seminar tutor)
PharmDr. Miroslav Turjap, Ph.D. (seminar tutor)
Renata Bláblová (assistant)
- Guaranteed by
- doc. MUDr. Regina Demlová, Ph.D.
Department of Pharmacology - Theoretical Departments - Faculty of Medicine
Contact Person: doc. MUDr. Regina Demlová, Ph.D.
Supplier department: Department of Pharmacology - Theoretical Departments - Faculty of Medicine
- Tue 13:50–15:30 B22/116 aula
- Prerequisites (in Czech)
- ZLPA0521c Pathology I - practice && ZLPF0521c Pathophysiol.I - practice && ZLCP051c Clin. Exam. in Surgery-pract.
- Course Enrolment Limitations
- The course is only offered to the students of the study fields the course is directly associated with.
- fields of study / plans the course is directly associated with
- Course objectives
- At the end of the course student should be able to understand integration in the field of biomedical sciences such as chemistry, physiology, molecular biology, pathology and pathological physiology clarifying mechanisms of xenobiotic (including drugs) effects and under which conditions they and their combinations may elicit therapeutic, adverse, and toxic effects, and what is the relation to the dose given, administration route, status of the organism (differences in pediatrics and geriatrics). They will be familiar with the requirements of "Good Clinical Practice" for development of new drugs, and duties of physicians in cooperation with the pharmaceutical industry and principles of pharmacovigilance.
Spring semester 2012 (Friday 1:30-3:10 p.m.)
- 1st week, February, 24
- The scope and historical development of modern pharmacology. Basic pharmacological terms, definitions. Drug regulation. Types of pharmacotherapy and drug effects.
- 2nd week, March, 2
- Drug-life cycle. Innovative and generic products. Biosimilars.
- 3rd week, March, 9
- Drug delivery approaches, routes of administration, prolonged release preparations.
- 4th week, March, 16
- Pre-clinical and clinical drug development. Drug registration guidance. Regulation and guidelines for "Good Clinical Practice".
- 5th week, March, 23
- Concentration-response relationship. Pharmacokinetic principles. Drug absorption, distribution, metabolism and elimination. Changes of drug effects after the repeated administration.
- 6th week, March, 30
- Mechanisms of drug action, non-specific, specific. Receptors and ligand binding. Receptor subtypes, autoreceptors, heteroreceptors.
- 7th week, April, 6:
- Physiological and pathological factors influencing drug effects. Drug interactions. Assessment of the seriousness of drug interactions. Adverse drug effects.
- 8th week, April, 13
- Pharmacogenetic, pharmacogenomic and their clinical implication.
- 9th week, April, 20
- Purposeful pharmacotherapy. Importance of the pharmacological anamnesis, monitoring of drug pharmacotherapy, risk of pharmacotherapy.
- 10th week,April, 27
- Drug therapy in children, general principles, pharmacokinetic and pharmacodynamic peculiarities. Pharmacotherapy in neonates.
- 11th week, May, 4
- Specificities of pharmacotherapy in the elderly.
- 12th week, May, 11
- The management of poisoning.
- 13th week, May, 18
- Principles of pharmacovigilance, duties of physicians and pharmaceutical companies, general rules in drug promotion.
- 14th week, May, 25
- Basic principles of pharmacoeconomics, types of pharmacoeconomic analyses and their relevant use in clinical practice.
- 15th week, June, 1:
- Immunomodulant and systemic enzyme pharmacotherapy.
- required literature
- LINCOVÁ, Dagmar and Hassan FARGHALI. Základní a aplikovaná farmakologie. 2., dopl. a přeprac. vyd. Praha: Galén, 2007. xxiv, 672. ISBN 9788072623730. info
- recommended literature
- Rang & Dale's pharmacology 7th Edition :with student consult online access. Edited by H. P. Rang. : Churchill Livingstone, 2012
- DOSTÁLEK, Miroslav, Jan JUŘICA, Eva JANOŠTÍKOVÁ and Lucia ZAHRADNÍKOVÁ. Farmakokinetika (Pharmacokinetics). ČR: Grada, 2006. 220 pp. Farmacie a farmakologie. ISBN 80-247-1464-7. info
- Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
- MARTÍNKOVÁ, Jiřina. Farmakologie pro studenty zdravotnických oborů. 1. vyd. Praha: Grada, 2007. 379 s. ISBN 9788024713564. info
- Teaching methods
- According to schedule given students are expected to attend lectures read by habilitated pharmacology teacher.
- Assessment methods
- There is no testing of knowledge in this part of study as students are expected to continue pharmacological course in the subsequent semester.
- Language of instruction
- Further comments (probably available only in Czech)
- Study Materials
The course is taught annually.