aVLBC0321p Biochemie I - přednáška

Lékařská fakulta
podzim 2019
Rozsah
3/0/0. 45. 0 kr. Ukončení: z.
Vyučující
doc. RNDr. Jiří Dostál, CSc. (přednášející)
RNDr. Hana Paulová, CSc. (přednášející)
Mgr. Jiří Slanina, Ph.D. (přednášející)
prof. RNDr. Eva Táborská, CSc. (přednášející)
doc. RNDr. Josef Tomandl, Ph.D. (přednášející)
Mgr. Jana Gregorová, Ph.D. (pomocník)
MUDr. Miroslava Hlaváčová, Ph.D. (pomocník)
PharmDr. Katarína Kostolanská (pomocník)
MUDr. Michaela Králíková, Ph.D. (pomocník)
Lenka Nerudová (pomocník)
Mgr. Ondřej Peš, Ph.D. (pomocník)
Mgr. Roman Sándor (pomocník)
Mgr. Marie Tomandlová, Ph.D. (pomocník)
Garance
prof. RNDr. Eva Táborská, CSc.
Biochemický ústav - Teoretická pracoviště - Lékařská fakulta
Dodavatelské pracoviště: Biochemický ústav - Teoretická pracoviště - Lékařská fakulta
Rozvrh
St 18. 9. až St 9. 10. St 10:00–10:50 A11/114, St 23. 10. až St 6. 11. St 10:00–10:50 A11/114, St 20. 11. až St 18. 12. St 10:00–10:50 A11/114, Po 9:00–10:50 A11/114; a St 16. 10. 8:00–8:50 A11/234, St 13. 11. 10:00–10:50 A11/334
Předpoklady
aVLBF011c Biophysics - practice && aVLBI0222c Biologie II - cvičení
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory
Cíle předmětu
The aim of the course is to obtain knowledge on essential metabolic processes on the cell level. Understanding of these proceses is a base for comprihension of metabolism on the tissue and organ level. In the introductory lessons are summarized basic terms from chemistry needed for understanding of body structure a physico-chemical processes occuring in it ((chemical composition of the body, survay of biologically important elements,water, elektrolytes, non-elektrolytes, osmotic pressure, acid-base, redox and precipitation reactions), the following lectures are focused on biochemical pathways in cells.
Výstupy z učení
At the end of the course students will:
- understand the meaning of basic chemical terms (pH, osmolality, electrolyte, buffer, etc.) and apply this knowledge when describing the properties of body fluids.
- describe the role of macro- and microbiogenic elements in the organism
- discusse the properties and function of enzymes
- describe basic catabolic and anabolic pathways of carbohydrate, lipid and protein metabolism, and their relationships.
- understand the principles of energy production, utilization and deposition at the cellular level.
- explain the function of cell membranes and the principle of compartmentalization at the cellular level and the transport processes on the membrane.
- describe protein synthesis, starting with the replication and transcription, translation and post-translational modifications. Understand the relationship between protein structure and function.
- explain the function of hemoglobin in oxygen transport and maintaining acid-base balance.
- discusse the principles of some diseases at the molecular level.
Osnova
  • Chemical composition of human body, biogenic elements. Water (properties, distribution), electrolytes, non-electrolytes, osmolality.
  • Acid-base reactions, pH, buffers, Henderson-Hasselbalch equation.
  • Bioenergetics (Gibbs energy, high-energy compounds, chemical equilibrium). Introduction to metabolism.
  • Redox reactions (redox potential, Nernst-Peters equation, biological redox systems).
  • Enzymes (classes, nomenclature). Characteristic features, enzyme kinetics, inhibition.
  • Cofactors (overview, functions, relation to vitamins).
  • Three phases of catabolism, citrate cycle, respiratory chain, oxidative phosphorylation.
  • Saccharides (structures), saccharides in nutrition, digestion.
  • Metabolism of glucose, transport of glucose into cells, glycolysis (aerobic, anaerobic). Pyruvate dehydrogenase complex. Gluconeogenesis.
  • Glycogen (synthesis, catabolism).
  • Metabolism of fructose, galactose, lactose. Pentose phosphate pathway. Glycosaminoglycans, proteoglycans.
  • Lipids and fatty acids (classification, structure). Lipids in nutrition. Lipophilic vitamins.
  • Digestion of lipids, surfactants. Fatty acids (structure, synthesis, catabolism).
  • Triacylglycerols (synthesis and degradation). Ketone bodies (synthesis, catabolism), phospholipids (structural types, synthesis, catabolism).
  • Lipid peroxidation (reactions, products, antioxidants).Eicosanoids (main features of synthesis). Cholesterol (structure, synthesis, regulation, conversions).
  • Bile acids (structure, synthesis, conversions). Calciols (structure, synthesis, conversions).
  • Amino acids (structure, properties). Peptides. Proteins (structure, folding, properties, structure of myosin, collagen, immunoglobulins).
  • Hemoglobin, myoglobin (structure, functions, Bohr effect), hemoglobinopathies.
  • Digestion of proteins, intracellular degradation of proteins. General features in metabolism of amino acids. Ammonia – sources, transport forms, detoxication.
  • Catabolism of individual amino acids.
  • Synthesis of non-essential amino acids. Congenital disorders of amino acids metabolism. Conversions of amino acids to specialized products I (synthesis of biogenic amines, creatine, melanine, iodo-thyronines).
  • Conversions of amino acids to specialized products II (synthesis of heme, porfyrias).
  • Structure of nucleosides and nucleotides, uric acid. Synthesis and catabolism of purine and pyrimidine bases, synthesis of nucleotides.
  • Structure of DNA, replication, repairs.
  • Structure of RNA, transcription and its regulation, processing.
  • Synthesis of proteins, folding.
  • Transport and sorting of proteins, post-translational modifications.
  • Biosynthesis of collagen, elastin, proteoglycans.
Literatura
    povinná literatura
  • KOOLMAN, Jan a Klaus-Heinrich ROEHM. Color Atlas of Biochemistry. 3rd ed. : Georg Thieme Verlag, 2013. ISBN 978-3-13-100373-7. info
  • RODWELL, Victor W., David A. BENDER a Kathleen M. BOTHAM. Harper's illustrated biochemistry. 30th ed. New York: Mc Graw- Hill, 2015. xii, 817. ISBN 9781259252860. info
  • Lecture files including lectures notes available in IS
    doporučená literatura
  • RONNER, Peter. Netter's Essential Biochemistry. Philadelphia: Elsevier, 2018. 482 s. ISBN 978-1-929007-63-9. info
  • LIEBERMAN, Michael, Allan D. MARKS a Alisa PEET. Marks' basic medical biochemistry : a clinical approach. Illustrated by Matthew Chansky. 4th ed. Baltimore: Lippincott, Williams & Wilkins, 2013. ix, 1014. ISBN 9781451100037. info
  • VASUDEVAN, D. M., S. SREEKUMARI a Kannan VAIDYANATHAN. Textbook of biochemistry for medical students. Eighth edition. New Delhi: Jaypee The Health Sciences Publisher, 2016. xvi, 718. ISBN 9789385999741. info
Výukové metody
Teaching form are lectures.
Metody hodnocení
Subject is a first part of two-semestral subject Biochemistry and is not terminated by exam nor course unit credit.
Vyučovací jazyk
Angličtina
Další komentáře
Předmět je vyučován každoročně.
Předmět je zařazen také v obdobích podzim 2016, podzim 2017, podzim 2018.
  • Statistika zápisu (nejnovější)
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