aVLBI0121p Biology I - lecture

Faculty of Medicine
autumn 2019
Extent and Intensity
1/0/0. 0 credit(s). Type of Completion: z (credit).
Mgr. Kateřina Cetkovská, Ph.D. (lecturer)
prof. Ing. Petr Dvořák, CSc. (lecturer)
doc. Mgr. Lumír Krejčí, Ph.D. (lecturer)
Mgr. Pavel Krejčí, Ph.D. (lecturer)
Mgr. Vladimír Rotrekl, Ph.D. (lecturer)
prof. RNDr. Ondřej Slabý, Ph.D. (lecturer)
doc. MUDr. Iva Slaninová, Ph.D. (lecturer)
prof. MUDr. David Šmajs, Ph.D. (lecturer)
RNDr. Mário Špírek, PhD. (lecturer)
Mgr. Stjepan Uldrijan, CSc. (lecturer)
Mgr. Kateřina Vopěnková, Ph.D. (lecturer)
Ing. Lívia Eiselleová, Ph.D. (seminar tutor)
Mgr. Kateřina Straková, Ph.D. (seminar tutor)
Jana Růžičková (assistant)
Guaranteed by
prof. Ing. Petr Dvořák, CSc.
Department of Biology - Theoretical Departments - Faculty of Medicine
Contact Person: Mgr. Kateřina Vopěnková, Ph.D.
Supplier department: Department of Biology - Theoretical Departments - Faculty of Medicine
Thu 19. 9. 11:00–11:50 A11/114, Thu 26. 9. 11:00–11:50 A11/114, Thu 3. 10. 11:00–11:50 A11/114, Thu 10. 10. 11:00–11:50 A11/114, Thu 17. 10. 11:00–11:50 A11/114, Thu 24. 10. 11:00–11:50 A11/114, Thu 31. 10. 11:00–11:50 A11/114, Thu 7. 11. 11:00–11:50 A11/114, Thu 21. 11. 11:00–11:50 A11/114, Thu 28. 11. 11:00–11:50 A11/114, Thu 5. 12. 11:00–11:50 A11/114, Thu 19. 12. 11:00–11:50 A11/114
Knowledge of high-school biology on the level of Overview of High School Biology (https://is.muni.cz/auth/do/med/el/overview/overview_ENG.qwarp) or similar, and knowledge of all previous lectures and practical classes of the subject. Expected knowledge for each lecture is specified in the course syllabus. Literature recomended to study before each lecture is detailed in the interactive syllabus of the course.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The main objectives of the course are:
- understanding the elementary cellular processes and the principle of intercellular communication
- understanding the principle of developing bacterial, viral and genetically determined diseases
Learning outcomes
After completing the course, the student will be able to:
- explain elementary processes taking place in cells and the human body (gene expression, intercellular communication, cell differentiation, cell division, cell death) and their purposes
- express the basic coherence between malfunctioning cellular processes and development of diseases
- explain the general mechanism of pathogenesis in bacterial and viral diseases
- explain the general mechanism of pathogenesis of gene mutations and chromosome aberrations in humans, and illustrate it with examples
- explain the effects of therapies interacting with cellular processes; explain the principles of anti-bacterial, anti-viral and anti-mitotic treatment
  • Introduction to medical biology – from understanding the cellular principle to modern biomedicine
  • Bacteria and viruses – characteristics, reproduction strategies and principles of treatment
  • Structure, functions and function anomalies of eukaryotic cells
  • The importance of genetic information – from genes to proteins; DNA replication
  • Cell signalling and the principle of cell differentiation
  • Cells in the context of the entire organism – principles of cell adhesion
  • Cell cycle – molecular mechanisms of regulation and significance for oncology
  • Mitotic division in normal and cancer cells
  • Meiosis and the principle of genetic variability
  • Basics of genetics, the nature of dominance and recessivity
  • Genetics of human diseases – molecular principles of genetically determined disorders
  • Cell death – mechanisms and regulation of apoptosis, its significance for medicine
  • Epigenetics – the link between genes and environment
    required literature
  • ALBERTS, Bruce. Essential cell biology. 4th edition. New York, N.Y.: Garland Science, 2014. xxiii, 726. ISBN 9780815344551. info
  • Medical genetics at a glance. Edited by D. J. Pritchard - Bruce R. Korf. 3rd ed. Chichester, England: Wiley-Blackwell, 2013. 1 online r. ISBN 9781118689028. info
Teaching methods
lecture every week
Assessment methods
Lecture attendance is optional. Without examination - Biology I is continued with Biology II which is completed with a written examination test based on knowledge of all topics from both semesters (lectures, seminars, practices).
Language of instruction
Follow-Up Courses
Further comments (probably available only in Czech)
The course is taught annually.
Information on the extent and intensity of the course: 15.
Teacher's information
Students are obliged to follow the Interactive syllabus of the course where they can find all relevant information (schedule, substitutions, public holidays etc.), and also corresponding study literature for each week, and links to animations and videos relevant to the topic (https://is.muni.cz/auth/el/1411/podzim2019/aVLBI0121p/index.qwarp)

The two required textbooks can be borrowed from the Campus university library (https://kuk.muni.cz/?page=&lang=english). They are also available as electronic books which can be read on computers in the university library:
Essential cell biology by Alberts to be found through e-prezencka (https://kuk.muni.cz/?page=9&lang=english)
Medical genetics at a glance by Pritchard to be found at http://discovery.muni.cz

The course is also listed under the following terms Autumn 2015, Autumn 2016, Autumn 2017, autumn 2018, autumn 2020.
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