aVLFA0822p Pharmacology II - lecture

Faculty of Medicine
spring 2020
Extent and Intensity
2/0/0. 4 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. MUDr. Regina Demlová, Ph.D. (lecturer)
doc. PharmDr. Jan Juřica, Ph.D. (lecturer)
Mgr. MVDr. Leoš Landa, Ph.D. (lecturer)
MUDr. Jana Pistovčáková, Ph.D. (lecturer)
doc. PharmDr. Jana Rudá, Ph.D. (lecturer)
PharmDr. Ondřej Zendulka, Ph.D. (lecturer)
Mgr. Petra Amchová, Ph.D. (assistant)
Róbert Balog (assistant)
doc. RNDr. Ladislava Bartošová, Ph.D. (assistant)
Renata Bláblová (assistant)
Agnesa Gabuľová (assistant)
Mgr. Jana Merhautová, Ph.D. (assistant)
Mgr. Kateřina Nebeská (assistant)
Mgr. Kristýna Nosková, Ph.D. (assistant)
MUDr. Jana Nováková, Ph.D. (assistant)
PharmDr. Jitka Rychlíčková, Ph.D. (assistant)
Mgr. Barbora Říhová, Ph.D. (assistant)
Květoslava Sedlářová (assistant)
Mgr. Eva Vohlídalová (assistant)
Guaranteed by
doc. MUDr. Regina Demlová, Ph.D.
Department of Pharmacology - Theoretical Departments - Faculty of Medicine
Contact Person: PharmDr. Ondřej Zendulka, Ph.D.
Supplier department: Department of Pharmacology - Theoretical Departments - Faculty of Medicine
Timetable
Tue 17:00–18:40 A11/114
Prerequisites (in Czech)
aVLFA0721p Pharmacology I - lecture && aVLPF0622p Pathophysiology II - lect.
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of the course is to acquiant the students with drugs from selected pharmacotherapeutic groups.
Learning outcomes
At the end of the course student should be able choose and prescribe suitable drug for the patient with known indicication. The selection will be made with respect to all factors influencing drug safety and efficacy.
Syllabus
  • aVLFA0822p - Pharmacology II lecture

    Spring semester 2020

    17:00-18:40 A11/114

  • 18. 2. 2020
  • 1. DRUGS OF DISEASES WITH CHRONIC PULMONARY OBSTRUCTION, H 1/-ANTIHISTAMINES.
  • Lecture content: Effects of histamine and how to antagonize it. Classification of H1-antihistamines. Pharmacological review of drugs used in the therapy of diseases with chronic pulmonary obstruction.
  • 25. 2. 2020
  • 2. INTRODUCTION TO PSYCHOPHARMACOLOGY, ANTIPSYCHOTICS, ANTIPARKINSONICS
  • Lecture content: History and classification of psychotropic substances. Antipsychotics, antiparkinsonics – basic pharmacological review.
  • 3. 3. 2020
  • 3. ANTIDEPRESSANTS
  • Lecture content: Pharmacological review of antidepressants and their clinical use.
  • 10. 3. 2020
  • 4. ANXIOLYTICS, HYPNOSEDATIVES, ANTICONVULSANTS .
  • Lecture content: Anxiolytics, hypnosedatives, anticonvulsants - basic pharmacological review. The possibilities of modulation of GABAergic neurotransmission.
  • 17. 3. 2020
  • 5. ANTI-INFECTIVES I - ANTIBIOTICS
  • Lecture content: Introduction/principles of ATB therapy, modes of resistance, pharmacological review of single groups of ATBs.
  • 24. 3. 2020
  • ANTI-INFECTIVES II – ANTIMYCOTICS AND ANTIVIRALS
  • Lecture content: Systemic and local antimycotics; antiherpetics; pharmacotherapy of influenza; antiretrovirals; therapy of RSV and viral hepatitis – pharmacological review.
  • 31. 3. 2020 7. PHARMACOLOGY OF GIT – ULCER DISEASE, ANTIEMETICS, ANTIDIARRHEALS AND LAXATIVES
  • Lecture content: Pharmacological review of drugs acting on GIT.
  • 7. 4. 2020
  • 8. CYTOSTATICS AND TARGETED THERAPY IN ONCOLOGY
  • Lecture content: Introduction. Classification of cytostatics according to their mechanisms of action. Mechanisms of resistance to anticancer drugs. Role of single nucleotide polymorphisms (SNPs) and TDM in oncology. Basic pharmacological properties of selected cytostatics. Principles of targeted therapy in oncology. Monoclonal antibodies. Protein kinase inhibitors. Targeted immunotherapy.
  • 14. 4. 2020
  • 9. ANTIANGIAL DRUGS
  • Lecture content: Pharmacological review of drugs used in the treatment of both acute and chronic ischemic heart disease.
  • 21. 4. 2020
  • 10. ANTIHYPERTENSIVES
  • Lecture content: Pharmacological review of antihypertensives with special focus on drugs interfering with RAAS and diuretics. Second-line antihypertensives.
  • 28. 4. 2020
  • 11. DRUGS OF HEART FAILURE, ANTIARRHYTHMICS
  • Lecture content: Review of drugs used in the therapy of acute and chronic heart failure, Pharmacological review of antiarrhythmics.
  • 5. 5. 2020
  • 12. DRUGS INFLUENCING HEMOSTASIS
  • Lecture content: Pharmacological review of anticoagulants, antiplatelets, fibrinolytics, and hemostatics
  • 12. 5. 2020
  • 13. THERAPY OF INTOXICATIONS, SUBSTANCE ADDICTION
  • Lecture content: Review of most common intoxications and their symptomatology. General principles of poisoning management. Specific antidotes in poisoning therapy. Types of addiction, therapy of substance abuse.
  • 19. 5. 2020
  • 14. DRUG-DRUG INTERACTIONS
  • Lecture content: Classification of drug-drug interaction, evaluation of clinical relevance and seriousness oc drug interactions, management of drug interactions, possibilities of drug interactions monitoring, case-reports.
  • 26. 5. 2020
  • 15. PHYTOPHARMACOLOGY AND PHARMACOGNOSY
  • Lecture content: Natural sources of medicines, selected groups of herbal active components, herbal preparations. The most common herbal poisons.
Literature
    required literature
  • RANG, H. P. Rang & Dale's pharmacology. 8th ed. [Edinburgh]: Churchill Livingstone, 2016. xv, 760. ISBN 9780702053627. info
    recommended literature
  • WHALEN, Karen. Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins, 2015. xi, 664. ISBN 9781451191776. info
    not specified
  • Study materials in the IS, course aVLFA0822p and aVLFA0822c
  • Exam question outlines in the IS
Teaching methods
lectures
Assessment methods
The final evaluation of the course contains also results of the tests from practicals of both semesters and results of colloquium test.

The final mark is calculated by following method:

Relative weight of the mark from tests: 30 %
Relative weight of the mark from oral exam: 70 %

To calculate mark from the tests the following method will be used:
The summary score from all tests in courses VLFA07212c, VLFA07212p, VLFA08222c, and VLFA08222p is 230 pts. Minimum to pass through the course to the oral exam is 116 pts.
A = 205-230 pts
B = 185-204 pts
C = 155-184 pts
D = 140-154 pts
E = 117-139 pts
F = less than 116 pts

To calculate mark from the oral examthe following method will be used:
Three different questions are chosen by students from three different sets of questions at oral exam. Moreover the student answers additional questions of examinator. Drawn questions from General and Special pharmacology and the additional questions have relative weight of 30 %. The question on essential drugs has realtive weight 10 % in the final mark of the oral exam. When student is evaluated by F for any of these questions the overall rating of oral exam is also F.

In case of success with the ROPOT test, but classification F from the oral part, students enter the oral part next time and for the final mark the score from the last ROPOT attempt is used.
Language of instruction
English
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses

Zobrazit další předměty

Teacher's information

General pharmacology:

1. Pharmacology, sub-branches, origin of drugs, drug names.

2. Types of pharmacotherapy, rules of rational and safe phramacotherapy. The question of drug misuse.

3. Preclinical and clinical trials, stages.

4. Basic legislation related to drug use, Sources of information on drugs and medicinal products.

5. Solid and gaseous pharmaceutical drug dosage forms - overview and their influence on pharmacokinetics and pharmacodynamics.

6. Semi-solid and liquid pharmaceutical drug dosage forms - overview and their influence on pharmacokinetics and pharmacodynamics.

7. Routes of drug administration – overview, characteristics.

8. Drug absorption, presystemic elimination, drug bioavailability.

9. Drug distribution, volume of distribution, redistribution. General principles of drug movement through the body.

10. Drug elimination, processes of the first and zero order, drug accummulation.

11. Drug biotransformation – stages, examples.

12. Drug excretion (ways of excretion, possibilities of their influence).

13. Therapeutic monitoring of drugs (TDM).

14. Pharmacokinetics of single, repeated and continual drug administration.

15. Modes of drug action

16. Inhibition and induction of enzymes in pharmacokinetics and pharmacodynamics of drugs – examples.

17. Synergism and antagonism in drug effect (pharmacokinetics, pharmacodynamics).

18. Dose – response curves, types of doses, drug anamnesis, patient‘s adherence.

19. Adverse drug reactions (types, categories, examples).

20. Pharmacovigilance, drug safety.

21. Primary resistance of the patient to the treatment. Influence of repeated administration on drug efficacy - examples of tolerance and tachyphylaxis.

22. Factors influencing the drug effect – examples.

23. Pharmacotherapy in elderly, the influence of co-morbidities on drug effect, polypharmacy.

24. Pharmacotherapy in pediatric population, in breastfeeding women. Drugs influencing breast feeding.

25. Pharmacotherapy in pregnancy, drug teratogenicity.

26. Pharmacogenetics, influence of genetic polymorfisms on pharmacokinetics and pharmacodynamics of drugs.

27. Drug interactions - overview, examples.

28. Principles of biological treatment – classification, technology, examples of clinical use.

Special pharmacology:

1. Sympathomimetics - overview of single classes and their indications, examples of drugs

2. Sympatholytics - overview of single classes and their indications, examples of drugs

3. Cholinomimetics

4. Cholinolytics

5. Antispasmodics - GIT + UGT

6. Opioid analgesics

7. NSAIDs, non-opioid analgesics, antimigraine agents

8. Antiuratics, antirheumatics incl. DMARDs

9. General anesthetics

10. Local anesthetics

11. Muscle relaxants

12. Antidiabetics (except insulines)

13. Insulins

14. Sex hormones and hormones of H-P axis

15. Uterotonics and tocolytics

16. Glucocorticoids

17. Immunostimulants + immunosuppressants (except glucocorticoids)

18. Drugs used in osteoporosis, pharmacology of thyroid gland

19. Antiasthmatics, drugs used in COPD

20. Antitussives, mucoactive drugs

21. H1 antihistamines

22. Antipsychotics

23. Drugs of neurogenerative diseases (Parkinson’s disease; dementia)

24. Antidepressants - iMAO+SSRI+NDRI

25. Antidepressants - tricyclic, NASSA, MASSA, SARI, SNRI, NARI, SMS

26. Nootropics, cognitive enhancers

27. Psychotomimetics, drugs used in ADHD

28. Anticonvulsants

29. Hypnosedatives, anxiolytics

30. Aminoglycosides

31. Principles of antibacterial therapy – overview, modes of action, resistance, MIC, MBC

32. Lincosamides, glycopeptides, polymyxins

33. Tetracyclines + related ATBs, amphenicoles

34. Cephalosporines, monobactams

35. Penicillins, carbapenems

36. Sulphonamides, nitrofurans and nitroimidazoles

37. Macrolides and related ATBs

38. Quinolones, antituberculotics

39. Antimycotics

40. Dermatologics – overview of classes, drugs and effects

41. Antivirotics

42. Antiemetic drugs, prokinetics, antivertigo drugs

43. Laxatives, antidiarrhoics, drugs of infectious diarrhoeas

44. Antiulcer agents, hepatoprotectives and drugs influencing the production and excretion of bile

45. Alkylating cytostatics and other drugs aiming on DNA in oncology

46. Biological treatment of autoimmune diseases 47. Targeted treatment in oncology

48. Antimetabolites + hormonal therapy in oncology

49. Hypolipidemics, anti-obesity drugs

50. Antiangial agents

51. Antihypertensives – drugs targeting RAAS

52. Antihypertensives – diuretics and aldosterone antagonists

53. Antihypertensives beta blockers + central antihypertensives

54. Antihypertensives - calcium channel blockers, α1 lytics

55. Antiarrhythmics

56. Drugs used in heart failure

57. Antiplatelet agents

58. Fibrinolytics, antifibrinolytics

59. Anticoagulants

60. Antianemics, hemostatics

61. Drugs causing addiction

62. Drugs used in the treatment of addiction

63. General principles of drug poisoning, specific antidotes and their mechanisms of action

64. Drugs for inflammatory bowel disease

65. Drugs used in erectile dysfunction and BHP

66. Vitamins

67. Antiglaucomatics and cycloplegics

„Essential drugs“

1. adrenalin/noradrenalin

2. dobutamine

3. ephedrine/pseudoephedrine

4. phenylephrine

5. oxymetazoline

6. methyldopa

7. salbutamol

8. doxazosin

9. metoprolol

10. timolol

11. atropin

12. butylscopolamine

13. fenpiverine/pitofenon

14. pilocarpine

15. rivastigmine

16. physostigmine

17. solifenacin

18. paracetamol/ASA

19. ibuprofen/diclofenac

20. indometacin

21. nimesulide/meloxicam

22. buprenorphine

23. morphine/naloxone

24. sufentanil

25. tramadol

26. metamizole

27. allopurinol

28. sumatriptan

29. desflurane

30. propofol

31. ketamine

32. procaine/lidocaine

33. suxamethonium

34. prilocaine

35. metformin

36. glimepiride

37. sitagliptin

38. insulin lispro

39. insulin glargine

40. ethinylestradiol

41. cyproterone

42. tibolone

43. tamoxifen

44. hexoprenaline

45. oxytocin

46. levonorgestrel

47. dexametasone

48. prednisone

49. cyclosporine

50. interferons

51. methotrexate

52. ibandronic acid

53. acetylcysteine

54. codeine

55. butamirate

56. ipratropium-bromide

57. bisulepine/cetirizine

58. haloperidol

59. olanzapine

60. aripiprazole

61. levodopa/carbidopa

62. escitalopram

63. amitriptyline

64. mirtazapine

65. lithium

66. methylphenidate

67. piracetam/pyritinol

68. diazepam

69. buspirone

70. gabapentin/pregabalin

71. carbamazepine

72. valproic acid

73. zolpidem

74. midazolam

75. doxycycline

76. co-amoxicillin

77. phenoxymethylpenicillin

78. piperacillin

79. meropenem

80. cefuroxim

81. cotrimoxazol

82. clarithromycin

83. azithromycin

84. gentamicin

85. ciprofloxacin

86. vancomycin

87. rifampicin

88. terbinafine

89. caspofungin

90. amphotericin B

91. fluconazole

92. acyclovir

93. zidovudine

94. isotretinoin

95. salicylic acid

96. ondansetron

97. moxastine

98. pantoprazole

99. famotidine

100. lactulose

101. aprepitant

102. metoclopramide

103. loperamide

104. betahistine

105. cinnarizine

106. cyclophosphamide

107. methotrexate

108. 5-fluorouracil

109. paclitaxel

110. doxorubicin

111. cisplatin

112. trastuzumab

113. imatinib

114. interferon alfa

115. nivolumab

116. atorvastatine

117. fenofibrate

118. ezetimibe

119. isosorbid dinitrate/nitroglycerin

120. hydrochlorothiazide/indapamide

121. furosemid

122. spironolactone

123. amlodipine

124. perindopril

125. telmisartan

126. digoxin

127. amiodarone

128. verapamil

129. levosimendan

130. warfarin

131. enoxaparin

132. clopidogrel

133. dabigatran

134. rivaroxaban

135. alteplase

136. methadone

137. buprenorphine

138. nalmefene

139. naltrexone

140. finasteride

141. sildenafil

The course is also listed under the following terms Spring 2018, spring 2019.
  • Enrolment Statistics (recent)
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