aVLMO051 Molecular and Cellular Pathophysiology

Faculty of Medicine
autumn 2021
Extent and Intensity
2/0/0. 3 credit(s). Type of Completion: z (credit).
Taught partially online.
Teacher(s)
RNDr. Jan Balvan, Ph.D. (lecturer)
MUDr. Jaromír Gumulec, Ph.D. (lecturer)
prof. MUDr. Kateřina Kaňková, Ph.D. (lecturer)
MUDr. Petr Müller, Ph.D. (lecturer)
Guaranteed by
prof. MUDr. Kateřina Kaňková, Ph.D.
Department of Pathophysiology - Theoretical Departments - Faculty of Medicine
Contact Person: RNDr. Jan Balvan, Ph.D.
Supplier department: Department of Pathophysiology - Theoretical Departments - Faculty of Medicine
Timetable
Tue 21. 9. to Fri 1. 10. Tue 14:30–16:10 A19/113, Mon 4. 10. to Fri 17. 12. Tue 14:30–16:10 A18/205
Prerequisites
( aVLFY0422c Physiology II - practice || aZLFY0422c Physiology II - practice || VLFY0422c Physiology II - practicals || ZLFY0422c Physiology II - practice ) && ( aVLFY0422s Physiology II - seminar || aZLFY0422s Physiology II - seminar || VLFY0422s Physiology II - seminar || ZLFY0422s Physiology II - seminar ) && ( aVLBC0422c Biochemistry II - pr. || aZLBC0422c Biochemistry II - pract. || VLBC0422c Biochemistry II || ZLBC0422c Biochemistry II - pract. ) && ( aVLBC0422s Biochemistry II - sem || aZLBC0422s Biochemistry II sem || VLBC0422s Biochemistry II sem || ZLBC0422s Biochemistry II - seminar )
Lecture builds on a student's knowledge from biology, histology and physiology and adds a context of pathophysiology at cellular and molecular levels. Students are expected to work wi scientific literature.
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 6 fields of study the course is directly associated with, display
Course objectives
Aim of this course is to describe molecular mechanisms of various diseases, including cancer, neurodegenerative diseases and pathologies associated with aging. The course is focused on molecular mechanisms of diseases and should link basic molecular biology principles with application in clinical medicine.
Learning outcomes
Students will be able to describe: - molecular mechanisms of stress response, cell death and other cellular processes associated with diseases - based on a knowledge of molecular mechanisms, to describe potential drug targets for therapeutic interventions - to apply evolutionary principles in a population genetics and epidemiology
Syllabus
  • 1. Inflammation-induced mutagenesis 2. Epigenetics 3. stress response and protein folding 4. Evolutionary influences in human diseases 5. Molecular mechanisms of aging, Cell senescence 6. migration and invasiveness in cancer, cell movement, Epithelial-mesenchymal transition 7. Mechanotransduction and mechanobiology 8. metabolism in cancer 9. Cell death 10. Apoptosis 11. Cell death in diseases 12. Autophagy
Teaching methods
lectures based on recent literature accompanied with class discussion.
Assessment methods
During the last week of the semester a test will be held (1 single answer).
Language of instruction
English
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Information on the extent and intensity of the course: 30.
Teacher's information
lectures based on recent literature accompanied with class discussion. Cell movement: 1. Paul, C.D., P. Mistriotis, and K. Konstantopoulos, Cancer cell motility: lessons from migration in confined spaces. Nature Reviews Cancer, 2017. 17(2): p. 131-140. 2. Petrie, R.J. and K.M. Yamada, At the leading edge of three-dimensional cell migration. J Cell Sci, 2012. 125(Pt 24): p. 5917-26. 3. Jacquemet, G., H. Hamidi, and J. Ivaska, Filopodia in cell adhesion, 3D migration and cancer cell invasion. Current Opinion in Cell Biology, 2015. 36: p. 23-31. Cell mechanics: Mutagenesis: 1. Olson ME, Harris RS, Harki DA. APOBEC Enzymes as Targets for Virus and Cancer Therapy. Cell Chem Biol. 2018 Jan 18;25(1):36-49. doi: 10.1016/j.chembiol.2017.10.007. Epub 2017 Nov 16. PMID: 29153851; PMCID: PMC5775913.

  • Enrolment Statistics (recent)
  • Permalink: https://is.muni.cz/course/med/autumn2021/aVLMO051