aZLBC0221s Biochemie I - seminář

Lékařská fakulta
jaro 2020
Rozsah
0/2/0. 30. 2 kr. Ukončení: z.
Vyučující
Ing. Martina Čarnecká, Ph.D. (cvičící)
doc. RNDr. Jiří Dostál, CSc. (cvičící)
Mgr. Jana Gregorová, Ph.D. (cvičící)
MUDr. Miroslava Hlaváčová, Ph.D. (cvičící)
MUDr. Michaela Králíková, Ph.D. (cvičící)
RNDr. Hana Paulová, CSc. (cvičící)
Mgr. Ondřej Peš, Ph.D. (cvičící)
Mgr. Jiří Slanina, Ph.D. (cvičící)
prof. RNDr. Eva Táborská, CSc. (cvičící)
doc. RNDr. Josef Tomandl, Ph.D. (cvičící)
Mgr. Marie Tomandlová, Ph.D. (cvičící)
Lenka Nerudová (pomocník)
Garance
prof. RNDr. Eva Táborská, CSc.
Biochemický ústav - Teoretická pracoviště - Lékařská fakulta
Dodavatelské pracoviště: Biochemický ústav - Teoretická pracoviště - Lékařská fakulta
Předpoklady
aZLLC011s Lék. chemie, DM. - sem. || ZLLC011s Lék. chemie, DM. - sem.
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory
Cíle předmětu
Seminars are complementary to Biochemistry I lecture (ZLBC0221p). At the end of the course student understand and can describe the major metabolic pathways and their significance.
Výstupy z učení
1. Student discusses the properties and function of enzymes
2. Describes basic catabolic and anabolic pathways of carbohydrate, lipid and protein metabolism, and their relationships.
3. Understands the principles of energy production, utilization and deposition at the cellular level.
4. Explains the function of cell membranes and the principle of compartmentalization at the cellular level and the transport processes on the membrane.
5. Describes protein synthesis, starting with the replication and transcription, translation and post-translational modifications. Understand the relationship between protein structure and function.
6. Explains the function of hemoglobin in oxygen transport and maintaining acid-base balance.
7. Discusses the principles of some diseases at the molecular level.
Osnova
  • Introduction into the metabolism of cells (differences between prokatyotic and eukaryotic cell). Structure of haemoglobin and its relationship to the function. Hb types in the blood of healthy subjects, HbCO and MetHb, abnormal Hb types. Enzymes - reaction rate, progress curve, the Michaelis plot and Km, enzyme inhibition. Coenzymes, their relationship to vitamins. Written test I (Biochemical methods, hemoglobin, enzymology, coenzymes.) Membrane structure and assembly. Transport across membranes. Metabolism of glucose: Glycolysis under anaerobic and aerobic conditions and the oxidation of pyruvate. Gluconeogenesis. Glycogenesis and glycogenolysis. Metabolism of proteins. Common features of amino acid conversion. The synthesis of urea. Nitrogen balance. Important reactions in amino acid catabolism. Written test II (Membranes, transport across membranes, metabolism of saccharides and amino acids.) Biosynthesis and desaturation of fatty acids. The sources of essential fatty acids. Metabolism of triacylglycerols. Metabolism of phospholipids. Biosynthesis of eicosanoids. Peroxidation of lipids. Written test III (Metabolism of lipids.) The citric acid cycle. The respiratory chain and oxidative phosphorylation. Replication, transcription, proteosynthesis.
Literatura
    povinná literatura
  • Seminar texts available in Information system
Výukové metody
Course is based on group discusion to the given topics. The outlines of discusion are in the recommended textbook. Complementary materials are available in section Study materials.
Metody hodnocení
Credit. Conditions for giving the course-unit credit: Three short tests are written during the semester. Students that will obtain 52/75 points or more during the semester are not obliged to write the credit test. The other students will write the credit test with the 30 questions in the last week of the semester. The limit for passing the credit test is 14 points. All absences must be made up before writing the credit test. Students that will not fulfill this limit will be allowed to repeat the test once. Students that will not fulfill this requirement will not be given the course-unit credit. Obtaining of course-unit credits of practices and seminars is the pre-requisite for registration to the examination of Biochemistry I.
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Předmět je zařazen také v obdobích jaro 2016, jaro 2017, jaro 2018, jaro 2019.