aZLBI0222p Biologie II - přednáška

Lékařská fakulta
jaro 2020
1/0/0. 15. 3 kr. Ukončení: zk.
Mgr. Kateřina Cetkovská, Ph.D. (přednášející)
Ing. Lívia Eiselleová, Ph.D. (přednášející)
doc. Mgr. Lumír Krejčí, Ph.D. (přednášející)
RNDr. Pavel Krejčí, Ph.D. (přednášející)
Mgr. Vladimír Rotrekl, Ph.D. (přednášející)
prof. RNDr. Ondřej Slabý, Ph.D. (přednášející)
prof. MUDr. Iva Slaninová, Ph.D. (přednášející)
prof. MUDr. David Šmajs, Ph.D. (přednášející)
Mgr. Stjepan Uldrijan, CSc. (přednášející)
Mgr. Kateřina Vopěnková, Ph.D. (přednášející)
Jana Růžičková (pomocník)
Mgr. Kateřina Straková, Ph.D. (náhr. zkoušející)
prof. MUDr. David Šmajs, Ph.D.
Biologický ústav - Teoretická pracoviště - Lékařská fakulta
Kontaktní osoba: Ing. Lívia Eiselleová, Ph.D.
Dodavatelské pracoviště: Biologický ústav - Teoretická pracoviště - Lékařská fakulta
Po 17. 2. až Čt 7. 5. Čt 8:00–8:50 B22/116 aula
aZLBI0121c Biologie I - cvičení || ZLBI0121c Biologie I - cvičení
Knowledge of high-school biology and all previous lectures and practical classes of the subject are prerequisites for studying the course. Expected knowledge for each lecture is specified in the course syllabus. The literature recommended for studying before each lecture is detailed in the interactive syllabus of the course.
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Cíle předmětu
The main objectives of the course are:
- understanding the mechanisms of cancer development
- understanding the complex taking place during human embryonic development
- acquaintance with the basics of genomics, gene therapy and tissue engineering in current medicine
Výstupy z učení
After completing the course, the student will be able to:
- explain the nature of cancers with regard to deregulation of cell division, DNA repair and cell death
- explain the effects of some therapies with emphasis on modern medicine (molecular therapies of cancer)
- explain the elementary processes taking place during the development of a human body
- express the basic coherence between malfunction in these processes and developmental defects
- explain the basic principles of current methods used in gene therapy and cell therapies
- understand the significance of the human microbiome composition
- be knowledgeable in basic modern approaches to studying various diseases and to personalised medicine (genomics, bioinformatics)
  • DNA damage and repair – from molecular mechanisms to clinical significance
  • Introduction to cancer biology
  • Oncogenes and oncoviruses in cancer transformation
  • Tumour suppressor genes and their significance for diagnostics and therapy
  • Paradigm of cancer stem cells and implications for anti-cancer therapies
  • Gene therapy – targets and strategies of molecular therapies
  • Stem cells and tissue engineering – prospects of regenerative medicine
  • From a single cell to human I – introduction to developmental biology
  • From a single cell to human II – molecular basis of mammalian development in health and disease
  • Human genome, genomics and bioinformatics in current biomedicine
  • Human microbiome
  • Modern approaches in studying macromolecules and their use in current biomedicine
    povinná literatura
  • ALBERTS, Bruce. Essential cell biology. 4th edition. New York, N.Y.: Garland Science, 2014. xxiii, 726. ISBN 9780815344551. info
  • Medical genetics at a glance. Edited by D. J. Pritchard - Bruce R. Korf. 3rd ed. Chichester, England: Wiley-Blackwell, 2013. 1 online r. ISBN 9781118689028. info
Výukové metody
lecture every week
Metody hodnocení
Lecture attendance is optional. The course of Biology II builds on the knowledge gained from Biology I, and is completed with a written examination test taken on computers. The test contains questions based on the topics discussed in the lectures and practices of both semesters. The students are expected to be able to autonomously solve assigned problems and to derive the solutions using their own thinking – based on the theory discussed during both semesters and supplemented by the recommended reading. The test contains 60 questions in total; at least 30 points are needed to pass.
Vyučovací jazyk
Navazující předměty
Informace učitele
Students are obliged to follow the Interactive syllabus of the course where they can find all relevant information (schedule, substitutions, public holidays etc.), and also corresponding study literature for each week, and links to animations and videos relevant to the topic (
The two required textbooks can be borrowed from the Campus university library ( They are also available as electronic books which can be read on computers in the university library:
Essential cell biology by Alberts to be found through e-prezencka (
Medical genetics at a glance by Pritchard to be found at
Další komentáře
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Předmět je zařazen také v obdobích jaro 2016, jaro 2017, jaro 2018, jaro 2019, jaro 2021, jaro 2022.