LF:VLFA0621c Pharmacology I - p - Course Information

VLFA0621c Pharmacology I - practice

Faculty of Medicine
Spring 2017

Extent and Intensity

0/3/0. 5 credit(s). Type of Completion: z (credit).

Teacher(s)

Guaranteed by

doc. MUDr. Regina Demlová, Ph.D.
Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Contact Person: doc. MUDr. Regina Demlová, Ph.D.
Supplier department: Department of Pharmacology – Theoretical Departments – Faculty of Medicine

Timetable of Seminar Groups

VLFA0621c/01: Wed 7:30–10:00 A19/231
VLFA0621c/02: Wed 7:30–10:00 A19/231, J. Rudá
VLFA0621c/03: Wed 10:20–12:50 A19/231
VLFA0621c/04: Wed 10:20–12:50 A19/231, J. Juřica
VLFA0621c/05: Fri 8:00–10:30 A19/231
VLFA0621c/06: Fri 8:00–10:30 A19/231
VLFA0621c/07: Fri 10:45–13:15 A19/231
VLFA0621c/08: Fri 10:45–13:15 A19/231, J. Pistovčáková
VLFA0621c/09: Mon 8:00–10:30 A19/231
VLFA0621c/10: Mon 8:00–10:30 A19/231
VLFA0621c/11: Mon 10:45–13:15 A19/231
VLFA0621c/12: Mon 10:45–13:15 A19/231
VLFA0621c/13: Tue 8:00–10:30 A19/231
VLFA0621c/14: Tue 8:00–10:30 A19/231
VLFA0621c/15: Thu 10:45–13:15 A19/231
VLFA0621c/16: Thu 10:45–13:15 A19/231, J. Pistovčáková
VLFA0621c/17: Tue 10:45–13:15 A19/231, O. Zendulka
VLFA0621c/18: Tue 10:45–13:15 A19/231, B. Říhová
VLFA0621c/30: Tue 13:30–16:00 A19/231, O. Zendulka
VLFA0621c/31: Wed 13:30–16:00 A19/326, J. Rudá
VLFA0621c/32: Thu 13:30–16:00 A19/326
VLFA0621c/33: Tue 13:30–16:00 A19/326
VLFA0621c/34: Wed 13:30–16:00 A19/231, J. Juřica
VLFA0621c/35: Thu 13:30–16:00 A19/326, J. Pistovčáková

Prerequisites (in Czech)

VSPF0521c Pathophysiol. I - practice. && VSPA0521c Pathology - practicals

Course Enrolment Limitations

The course is only offered to the students of the study fields the course is directly associated with.

fields of study / plans the course is directly associated with

General Medicine (eng.) (programme LF, M-VL)
General Medicine (programme LF, M-VL)

Course objectives

On completion of the course the student will be able to use formally correct terminology belonging to the valid Pharmacopoea in prescription and making of drug dosage forms of both individually prepared and bulk preparations. The student should be able to understand principles of "pharmacological thinking" for choosing a drug, dosing regimen, pharmacokinetic parameter calculation, differences in administration routes and specifics of pediatric and geriatric pharmacotherapy including possible impact of drug-drug interactions.

Learning outcomes

Syllabus

Pharmacology - practical courses

Spring semester 2017
1^st week (20.2.-24.2.)
Topic: INTRODUCTION, TERMINOLOGY, DOSES, PHARMACOLOGICAL CALCULATIONS.
Course content: Organisation of practical courses and lectures. Recommended textbooks. Pharmacology – definition, basic terminology, subspecializations. Experimental pharmaology. Drug nomenclature, type of doses. Pharmacopoea. Drug dosology in paediatrics.
Getting ready for next lesson: Repetition of latin terminology and pharmacological calculations.
Selfstudy: Prescription abbreviations.
2^nd week (27.2.-2.3.)
Topic: GENERAL RULES OF THE DRUG PRESCRIPTION
Course content: Medical prescription: Rules of the drug prescription. Prescription of individualy prepared and ready made preparations. Legislation of drug prescription. Work with various handbooks and databases (SÚKL database, Pharmindex, DynaMed.). Prescription of narcotic and psychotropic agents.
Getting ready for the next lesson: Repetition of general rules of drug prescription + abbreviations.
3^rd week (6.3.-10.3.)
Topic: FLUID DRUG DOSAGE FORMS FOR THE EXTERNAL USE, ORAL AND PARENTERAL USE. GASEOUS DRUG DOSAGE FORMS.
Course content: : Application and rinse solutions; eye, ear and nose lotions, suspensions - composition and prescription. Solutions for oral administration, drops, aromatic waters, tinctures. Terminology, classification, prescription.
4^th week (13.3.-17.3.)
Topic: SOLID DRUG DOSAGE FORMS. SOFT AND MELTING DRUG DOSAGE FORMS.
Course content: Powders for external and internal use, capsules, tablets, teas; suppositories. Ointments, creams, pastes, plasters. Terminology, classification, prescription. Getting ready for the next lesson: Repetition of general rules of the drug prescription.
5^th week (20.3.-24.3.)
Topic: INTRODUCTION TO THE PHARMACOKINETICS.
Course content: Basic pharmacokinetic processes and parameters. One- and two-compartment kinetic models. Kinetics of the intravascular and extravascular drug administration. Kinetics of single and repeated drug administration. Getting ready for the next lesson: Pharmacokinetic calculations.
TEST Lessons 1-4
6^th week (27.3.-31.3.)
Topic: CASE REPORTS I - PHARMACOKINETIC INTERACTIONS. THERAPEUTIC DRUG MONITORING.
Course content: Computer techniques in pharmacokinetics. Therapeutic drug monitoring. Calculations of the basic pharmacokinetic parameters: Work with PC: Demonstration of software MW PHARM; Interactions of pharmacokinetic type.
Getting ready for the next lesson: Physiology of ANS.
7^th week (3.4.-7.4.)
Topic: PHARMACOLOGY OF THE SYMPATHETIC NERVOUS SYSTEM I. SYMPATHOMIMETICS.
Course content: Receptor theory, neurotransmission in PNS. Therapeutic use of sympathomimetics.
TEST Lessons 2-6
8^th week (10.4.-14.4.)
Topic: PHARMACOLOGY OF THE AUTONOMIC NERVOUS SYSTEM II. SYMPATHOLYTICS
Course content: Therapeutic use of sympatholytics.
9^th week (17.4.-21.4.)
Topic: PHARMACOLOGY OF THE SYMPATHETIC NERVOUS SYSTEM III. CHOLINERGIC DRUGS.
Course content: Therapeutic use of cholinergic drugs.
Getting ready for the next lesson: Pathophysiology of ulcer disease and vomitus.
10^th week (24.4.-28.4.)
Topic: PHARMACOLOGY OF GASTRODUODENAL ULCER DISEASE, PROKINETICS, ANTIEMETICS.
Course content: Classification, mechanisms of action and clinical use of drugs in therapy of peptic ulcer and vomiting.
Getting ready for the next lesson: Repetition of physiology of adrenal cortex hormones, repetition of pathophysiology of disorders caused by hyperproduction or insufficiency of adrenal cortex hormones.
11^th week (1.5.-5.5.)
Topic: GLUCOCORTICOIDS.
Course content: Physiology and pathophysiology of adrenal cortex hormones. Natural and synthetic adrenocorticosteroids, steroid receptors, mechanism of action, pharmacological use and side effects. Examples of ready-made drug preparations.
Getting ready for the next lesson: Repetition of physiology and biochemistry of thyroidal and sex hormones.
TEST Lessons 7-10
12^th week (8.5.-12.5.)
Topic: PHARMACOLOGY OF ENDOCRINE SYSTEM.
Course content: Endocrine therapy, hormone replacement therapy, hormonal contraceptive drugs, thyroid hormones.
Getting ready for next lesson: Repetition of pathophysiology of diabetes mellitus.
13^th week (15.5.-19.5.)
Topic: ANTIDIABETIC DRUGS.
Course content: Therapy of type 1 and 2. DM. Insulines. Peroral antidiabetics. Examples of ready-made drug preparations.
TEST Lessons 11-12
14^th week (22.5.-26.5.)
Topic: PHARMACOLOGY OF MEDICINAL PLANTS.
Course content: History, classification and chemistry of herbal drugs, their practical medicinal use. Demonstration and tasting of selected types of plant products (teas, macerates). Toxic herbs. Demonstration of selected drug forms and raw materials used for their preparation.
CREDITS.
15^th week (31.5.)
Topic: EXCURSION TO THE CENTRE OF MEDICINAL PLANTS.
ATTENDANCE VOLUNTARY

Literature

required literature

RANG, H. P., James RITTER, R. J. FLOWER and Graeme HENDERSON. Rang & Dale's pharmacology. Eighth edition. [Edinburgh]: Churchill Livingstone. xv, 760. ISBN 9780702053627. 2016. info
http://portal.med.muni.cz/clanek-611-zaklady-specialni-receptury-lecivych-pripravku.html
For English speaking students: Practicals in Pharmacology http://portal.med.muni.cz/discipline-13-pharmacology

recommended literature

LINCOVÁ, Dagmar and Hassan FARGHALI. Základní a aplikovaná farmakologie. 2., dopl. a přeprac. vyd. Praha: Galén. xxiv, 672. ISBN 9788072623730. 2007. info
http://portal.med.muni.cz/clanek-621-zivotni-cyklus-leciv-klinicke-hodnoceni-a-registrace-lecivych-pripravku-farmakovigilance-a-stanovovani-cen-a-uhrad-leciv.html
http://portal.med.muni.cz/clanek-461-farmakovigilance-a-propagace-leciv.html
http://elportal.cz/publikace/kazuistiky-farmakologie
http://portal.med.muni.cz/clanek-649-zaklady-farmakoekonomiky.html
Pharmaceutical practice. Edited by Judith A. Rees - Ian Smith - Jennie Watson. 5th ed. Edinburgh: Churchill Livingstone Elsevier. xvii, 552. ISBN 9780702051432. 2014. info

not specified

http://portal.med.muni.cz/clanek-553-zaklady-receptury-lecivych-pripravku.html
Český lékopis 2009. Praha: Grada. 1 DVD-ROM. ISBN 8594049240180. 2011. info
WHALEN, Karen. Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins. xi, 664. ISBN 9781451191776. 2015. info
DOSTÁLEK, Miroslav, Jan JUŘICA, Eva JANOŠTÍKOVÁ and Lucia ZAHRADNÍKOVÁ. Farmakokinetika (Pharmacokinetics). ČR: Grada. 220 pp. Farmacie a farmakologie. ISBN 80-247-1464-7. 2006. info
Waller, Derek - Renwick, Andrew G. - Hillier, Keith. Medical pharmacology and therapeutics. 3rd ed. New York : Elsevier Saunders, 2009. ix, 744 p. ISBN 0-7020-2991-2.
Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
http://portal.med.muni.cz/clanek-652-behavioralni-metody-v-neuropsychofarmakologii.html
http://portal.med.muni.cz/clanek-367-vyzkum-novych-leciv-od-zrodu-k-registraci.html
http://portal.med.muni.cz/clanek-644-farmakologie-pro-studenty-bakalarskych-oboru-na-lf-mu.html

Teaching methods

Practicals, the teaching process of include theoretical setting up as well as practical training of knowledge and skills stated in Syllabus. Included are also individual work with specific pharmacological softwares and homeworks on the selected topics, presented and discussed afterward in class.

Assessment methods

The participation in practicals is obligatory and registered. To get a credits a student has to pass 3 written tests: a) on drug prescription (assessed individually by the teacher), b)3 x multiple-choice test on knowledge of topics taught (score higher than 60% of maximum to pass, 8 pts. out of 15).

Language of instruction

Czech

Further comments (probably available only in Czech)

The course is taught annually.

The course is also listed under the following terms Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016.

Enrolment Statistics (recent)
Permalink: https://is.muni.cz/course/med/spring2017/VLFA0621c

LF:VLFA0621c Pharmacology I - p - Course Information

VLFA0621c Pharmacology I - practice

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