VZpB52 Genetics

Faculty of Education
Autumn 2023
Extent and Intensity
1/1/0. 4 credit(s). Type of Completion: zk (examination).
Taught in person.
Teacher(s)
PhDr. Mgr. Lenka Adámková, Ph.D. (lecturer)
Mgr. et Mgr. Lenka Falk, Ph.D. (lecturer)
doc. MUDr. Petr Kachlík, Ph.D. (lecturer)
Guaranteed by
doc. MUDr. Petr Kachlík, Ph.D.
Department of Physical Education and Health Education – Faculty of Education
Contact Person: Andrea Špačková
Supplier department: Department of Physical Education and Health Education – Faculty of Education
Timetable of Seminar Groups
VZpB52/PrezSem01: Mon 18:00–19:50 učebna 24, Mon 18:00–19:50 učebna 24, L. Falk
Prerequisites (in Czech)
VzpB21 Human biology and basic health education 2
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
On the basis of the knowledge acquired the students will understand the importance of inherited qualities of an individual, describe the human genome, the principle of mutations, causes and consequences of their occurrence, basic genetic diseases, and the causes of lifestyle diseases in a broader context.
Learning outcomes
Upon completion of the course the students will: Be able to clearly explain the basic genetic concepts, Mendel’s laws and principles of heredity, Understand and be able to explain examples of monohybridism and dihybridism, propose suitable teaching examples for elementary schools, Understand the molecular principle of heredity, function of nucleic acids, and gene expression, Be able to see the human genome in the context of the creation, development and health of a human being.
Syllabus
  • 1. Basic genetic concepts and principles: heredity, variability, gene, allele and their relations, genotype, phenotype; 2. Basic genetic principles: Mendel’s phenotype laws. Monohybridism, dihybridism; 3. Chromosomal principle of heredity. Structure and significance of chromosomes. Human karyotype; 4. Cell cycle, mitosis, meiosis. Gametogenesis. Cell cycle regulation; 5. Molecular principle of heredity. Structure and function of nucleic acids. Genome; 6. DNA replication. Gene expression – transcription, translation. Genetic code. Protein synthesis. Human genome; 7. Monogenic inheritance in humans. Mutation. Genetic disorders in humans – gene-based. Autosomal dominant, autosomal recessive disorders; 8. Deviations from Mendelian segregation ratios. Gene linkage. Gene interaction. Gonosomal inheritance. Extranuclear inheritance; 9. Genetic disorders in humans – genome mutations. Aneuploidy in humans; 10. Genetic disorders in humans – chromosomal aberrations. Mutagens; 11. Inheritance of quantitative traits. Polygenous inheritance in humans. Multifactorial and complex traits in humans. Cancer – genetic disease; 12. Genetic prevention. Prenatal diagnosis. Assisted reproduction, pre-implantation diagnosis. Content of seminars: 1. Basic genetic principles, dominance and recessiveness; 2. Mendel’s crossing peas experiments; 3. Principle of segregation – training on specific examples of non-pathological traits in humans; 4. Monohybridism – training on specific examples of pathological traits in humans; 5. Inheritance of blood groups in humans, AB0 system, Rh-factor, molecular and biochemical principles, Bombay phenotype; 6. Blood groups – examples; 7. Principle of combination – training on specific examples of vegetable and animal organisms; 8. Dihybridism – training on specific examples of hereditary traits in humans; 9. Principles of segregation and combination in the context of cell division, mitosis, meiosis, chromatin replication and division; 10. Molecular principles – replication, transcription, translation – examples; 11. - 12. Bioethics in genetics – discussion on current issues (GMO, assisted reproduction, genetic research, etc.)
Literature
    required literature
  • NUSSBAUM, Robert L., Roderick R. MCINNES, Huntington F. WILLARD, James THOMPSON a Margaret Wilson THOMPSON. Klinická genetika: Thompson &Thompson : 6. vyd.Translated by Petr Goetz. Vyd. 1. Praha: Triton, 2004. 426, lix. ISBN 8072544756.
  • KŘEČEK, Jiří. Jedinec: Gen – prostředí – vývoj. 1. vyd. Praha: Academia, 2007. 232 s. ISBN 978-80-200-1490-0.
  • ŠMARDA, Jan. Genetika : pro gymnázia. Online. 1. vyd. Praha: Fortuna, 2003. 143 s. ISBN 8071688517. [citováno 2024-04-23] info
  • SNUSTAD, D. Peter and Michael J. SIMMONS. Principles of genetics [Snustad, Simmons, 2000]. Online. 2nd ed. New York: John Wiley & Sons, 2000. xviii, 876. ISBN 0-471-29800-X. [citováno 2024-04-23] info
Teaching methods
Theoretical preparation
Assessment methods (in Czech)
Zápočtová písemka, základní příklady z obecné genetiky, v polovině semestru a před zkouškou, pro úspěšné splnění je vyžadováno 60 %. Povinná prezence na semináři. Ústní zkouška.
Language of instruction
Czech
Further Comments
Study Materials
The course is taught annually.
The course is also listed under the following terms Autumn 2019, autumn 2020, Autumn 2021, Autumn 2022.
  • Enrolment Statistics (recent)
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