Bi4020 Molecular biology

Faculty of Science
Spring 2020
Extent and Intensity
3/0/0. 3 credit(s) (fasci plus compl plus > 4). Type of Completion: zk (examination).
Teacher(s)
prof. RNDr. Jan Šmarda, CSc. (lecturer)
prof. RNDr. Jana Šmardová, CSc. (lecturer)
Guaranteed by
prof. RNDr. Jan Šmarda, CSc.
Department of Experimental Biology - Biology Section - Faculty of Science
Contact Person: prof. RNDr. Jiří Doškař, CSc.
Supplier department: Department of Experimental Biology - Biology Section - Faculty of Science
Prerequisites
! Bi4010 Essential molecular biology
Basic knowledge of general zoology and botany, microbiology, genetics, physiology, organic chemistry and biochemistry.
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
Fields of study the course is directly associated with
there are 31 fields of study the course is directly associated with, display
Course objectives
The aim of the subject is to acquaint students with the structure of genomes of all groups of oragnisms, to explain how genetic information is stored in them, how this information is stored and realized. Students are familiar with the processes by which genetic information can change, its implications on the phenotypic level, and how to genetically change information.
Learning outcomes
Students will be able to understand and explain basic principles of molecular biology and genetics on molecular level and their basic phenomena - the structure, replication, expression and changes of genes.
Syllabus
  • 1. History of molecular biology. Nucleic acids (primary, secondary and tertiary structure of DNA and RNA, different conformations of DNA and their significance in biological systems)
  • 2. Genetic information and the genetic code.
  • . 3. Molecular structure of procaryotic and eucaryotic genome.
  • 4. Replication of procaryotic and eucaryotic genome
  • 5. Transcription of prokaryotic and euckryotic genome. Posttranscriptional modification and processing of RNA, especially in eukaryotes. Mechanisms of splicing and self-splicing
  • 6. Translation of prokaryotic and eukaryotic mRNA. Posttranslational processing
  • 7. Regulation of gene expression in prokaryotes and eukaryotes
  • 8. Molecular basis of acquired immunity
  • 9. Molecular mechanisms of mutagenesis and recombination Molecular basis of cancerogenesis (oncogenes, antioncogenes. Repair mechanisms of damaged DNA
  • 10. Mobile genetic elements, Transposons and retrotransposons.
  • 11. Basic principles of gene engineering
Literature
    recommended literature
  • WILSON, John and Tim HUNT. Molecular biology of the cell : the problems book / John Wilson and Tim Hunt. Sixth edition. New York: Garland Science, 2014. xvi, 966. ISBN 9780815344537. info
  • CLARK, David P. Molecular biology. Amsterdam: Elsevier, 2005. xviii, 784. ISBN 0121755517. info
  • ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky a : Essential cell biology (Orig.). Ústí nad Labem: Espero Publishing,. xxvi, 630,. info
    not specified
  • SNUSTAD, D. Peter and Michael J. SIMMONS. Genetika. Edited by Jiřina Relichová. Druhé, aktualizované vydá. Brno: Masarykova univerzita, 2017. xix, 844. ISBN 9788021086135. info
Teaching methods
Lectures are based on power-point pictures, tables and texts elaborated accordindg to textbooks, monographs and scientific papers which are explained and complemented with teacher comments. All the presentations are available on IS MUNI.
Assessment methods
Visiting of the course is not obligatory. The exam is a written test in which students should answer 50 questions covering main topics of individual lectures. To pass the exam the students should answer 60% of the answers.
Language of instruction
Czech
Follow-Up Courses
Further comments (probably available only in Czech)
The course is taught annually.
The course is taught: every week.
Listed among pre-requisites of other courses

Zobrazit další předměty

The course is also listed under the following terms Spring 2008 - for the purpose of the accreditation, Spring 2011 - only for the accreditation, Spring 2003, Spring 2004, Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, spring 2012 - acreditation, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, spring 2018, Spring 2019.
  • Enrolment Statistics (Spring 2020, recent)
  • Permalink: https://is.muni.cz/course/sci/spring2020/Bi4020