Course Information

Bi6871 Health Risks

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

doc. RNDr. Alena Hyršlová Vaculová, Ph.D. (lecturer)
prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)
Mgr. Jiřina Procházková, Ph.D. (lecturer)
Mgr. Petra Ovesná, Ph.D. (lecturer)

Guaranteed by

doc. RNDr. Alena Hyršlová Vaculová, Ph.D.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: doc. RNDr. Alena Hyršlová Vaculová, Ph.D.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science

Prerequisites

Required basic knowledge of biochemistry, cellular physiology and molecular biology. Associated with lectures of Physiology of cell systems and Mechanisms of carcinogenesis.

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 6 fields of study the course is directly associated with, display

Course objectives

The aim of the course is to acquaint students with the information about causes of the development of selected disorders and diseases, especially so-called civilization diseases, such as cancer, inflammation, allergies, stress, lung, liver and cardiovascular diseases, neurological and psychological disorders, including approaches and methods of their research, and selected epidemiology studies. It is focused especially on the impact of environmental factors (chemical and biological) on human health, the role of diet, lifestyle, and the use of knowledge in the prevention of diseases. Students will also learn about the existence and regulation of the body as a hierarchical system, essential processes necessary to maintain its normal functions, and factors that may interfere with these functions.

Learning outcomes

At the end of the course students should be able to: recognize the most important chemical and biological environmental factors and their impacts on human health at the level of specific organs as well as organisms as a whole, including possibilities of disease prevention; describe specific dietary factors and their association with etiology of some serious so-called civilization diseases, such as cardiovascular diseases, cancer, allergies or stress; understand the view of the organism as a hierarchical system and what are the basic processes necessary for maintenance of its homeostasis; interpret and use knowledge of environmental factors influencing human health and of possibilities of disease prevention; explain recent results of epidemiologic and scientific studies of given topic; learn the ability to elaborate and present assigned topic.

Syllabus

• - Úloha faktorů vnějšího prostředí v rozvoji jaterních onemocnění. Toxické látky, alkohol, vybrané složky výživy, virová hepatitida, životní styl atd. a jejich vliv na rozvoj nádorů jater a některých chronických onemocnění jater, související statistiky a epidemiologické studie. Poškození jater jako centrálního orgánu metabolismu a jeho dopad na celkový zdravotní stav organismu, příklady recentních studií, zhodnocení zdravotních rizik. - Environmentální faktory vyvolávající či přispívající ke vzniku fenoménu vývojové a chronické neurotoxicity. Chemické i biologické faktory, které se mohou běžně vyskytovat v našem prostředí a podílet se na vzniku a rozvoji neurologických poruch u dětí a starších osob. Jejich původ, způsoby expozice, epidemiologické studie prokazující jejich chronický a kumulativní účinek. Neurologická onemocnění a poruchy soustředění, narušení kognitivních funkcí, autismus, ADHD, Parkinsonova choroba vs. parkinsonimus, Alzheimerova choroba. - Interpretace různých typů studií z pohledu statistika: real-world data, klinické studie, metaanalýza. Co vše ovlivňuje interpretaci dat. Příklady z oblasti pneumologie a onkologie. - Toxické látky v ovzduší a cigaretovém kouři. Vliv kouření na zdraví lidského organismu s ohledem na rozvoj některých typů onemocnění, zejména plicních, kardiovaskulárních, cukrovky, vybraných nádorů atd., související statistiky a epidemiologické studie, zhodnocení zdravotních rizik, celkové důsledky pro organismus, příklady recentních studií. - Příčiny vzniku a rozvoje závažných onemocnění. Typy studií působení faktorů ovlivňujících zdraví. Závažná onemocnění a životní styl (škodlivé a preventivní faktory). Faktory ovlivňující vznik nádorů. Potrava a výživa, vztah ke zdraví a nemoci, nutrigenomika, farmakogenomika, inovativní technologie. Rovnováha příjmu a výdeje kalorií, obezita. Bioaktivní složky potravy. Podpůrné a preventivní faktory. Význam lipidů ve výživě. Biologická úloha lipidů. Vysoce nenasycené mastné kyseliny (VNMK, n-6 vs. n-3). Mechanismy působení VNMK. VNMK a mentální zdraví. Uplatnění poznatků v praxi. - Statistické pojmy běžně se vyskytující v literatuře a veřejně dostupných informačních zdrojích. Jak na ně nahlížet, jak je interpretovat, na co si dát pozor. Význam jednorozměrných a vícerozměrných modelů. Specifika analýzy přežití. - Role mikrobiomu v rozvoji neurologických/neuropatologických poruch a v rozvoji nádorového onemocnění.

Literature

recommended literature
• Food and Health in Europe: a new basis for action, WHO Regional Publications European Series, No. 96, 2006
• Wilhelm Z. a kol., Výživa v onkologii, (Nutrition in oncology) Brno 2004
• ZADÁK, Zdeněk. Výživa v intenzivní péči. 2. rozš. a aktualiz. vyd. Praha: Grada, 2009, 542 s. ISBN 9788024728445. info
• FOŘT, Petr. Co jíme a pijeme? Výživa pro 3. tisícitletí. (What we eat and drink? Nutrition for 3rd millenium) 1. vyd. Praha: Olympia, 2003. 246 s. ISBN 80-7033-814-8.
• Jak vzdorovat rakovině. (How to resist cancer) Edited by Olga Dostálová. [1. vyd.]. Praha: Grada-Avicenum, 1993. 205 s. ISBN 80-7169-040-6.
• Free radicals, aging, and degenerative diseases (Eds. J. E. Johnson, Jr., R. Walford, D. Harman, J. Miquel), Alan. R. Liss, Inc., New York 1986
• Speciální vybraná reviews a vědecké články (Thematic reviews and research papers)

Teaching methods

Basic lectures by teachers and associated discussion. Study of selected research topics and their presentation by students with class discussion.

Assessment methods

Attendance of the lectures is not mandatory but recommended for understanding the topics, discussion with other students and creating and expression student's own opinion. Prerequisite for the course completion is preparation of short presentation for class colleagues and discussion of assigned topic. The final examination is based on written exam evaluated by the teacher.

Language of instruction

Czech

Follow-Up Courses

• Bi7070 Physiology of Cell Systems
• Bi8110 Mechanisms of carcinogenesis

Further comments (probably available only in Czech)

The course is taught annually.
The course is taught: every week.
Information on course enrolment limitations: Na předmět se vztahuje povinnost registrace, bez registrace může být znemožněn zápis předmětu!

Bi6871 Health Risks

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

doc. RNDr. Alena Hyršlová Vaculová, Ph.D. (lecturer)
prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)
Mgr. Jiřina Procházková, Ph.D. (lecturer)
Mgr. Petra Ovesná, Ph.D. (lecturer)

Guaranteed by

doc. RNDr. Alena Hyršlová Vaculová, Ph.D.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: doc. RNDr. Alena Hyršlová Vaculová, Ph.D.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science

Timetable

Mon 19. 2. to Sun 26. 5. Thu 10:00–11:50 B11/306

Prerequisites

Required basic knowledge of biochemistry, cellular physiology and molecular biology. Associated with lectures of Physiology of cell systems and Mechanisms of carcinogenesis.

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 6 fields of study the course is directly associated with, display

Course objectives

The aim of the course is to acquaint students with the information about causes of the development of selected disorders and diseases, especially so-called civilization diseases, such as cancer, inflammation, allergies, stress, lung, liver and cardiovascular diseases, neurological and psychological disorders, including approaches and methods of their research, and selected epidemiology studies. It is focused especially on the impact of environmental factors (chemical and biological) on human health, the role of diet, lifestyle, and the use of knowledge in the prevention of diseases. Students will also learn about the existence and regulation of the body as a hierarchical system, essential processes necessary to maintain its normal functions, and factors that may interfere with these functions.

Learning outcomes

At the end of the course students should be able to: recognize the most important chemical and biological environmental factors and their impacts on human health at the level of specific organs as well as organisms as a whole, including possibilities of disease prevention; describe specific dietary factors and their association with etiology of some serious so-called civilization diseases, such as cardiovascular diseases, cancer, allergies or stress; understand the view of the organism as a hierarchical system and what are the basic processes necessary for maintenance of its homeostasis; interpret and use knowledge of environmental factors influencing human health and of possibilities of disease prevention; explain recent results of epidemiologic and scientific studies of given topic; learn the ability to elaborate and present assigned topic.

Syllabus

• - Úloha faktorů vnějšího prostředí v rozvoji jaterních onemocnění. Toxické látky, alkohol, vybrané složky výživy, virová hepatitida, životní styl atd. a jejich vliv na rozvoj nádorů jater a některých chronických onemocnění jater, související statistiky a epidemiologické studie. Poškození jater jako centrálního orgánu metabolismu a jeho dopad na celkový zdravotní stav organismu, příklady recentních studií, zhodnocení zdravotních rizik. - Environmentální faktory vyvolávající či přispívající ke vzniku fenoménu vývojové a chronické neurotoxicity. Chemické i biologické faktory, které se mohou běžně vyskytovat v našem prostředí a podílet se na vzniku a rozvoji neurologických poruch u dětí a starších osob. Jejich původ, způsoby expozice, epidemiologické studie prokazující jejich chronický a kumulativní účinek. Neurologická onemocnění a poruchy soustředění, narušení kognitivních funkcí, autismus, ADHD, Parkinsonova choroba vs. parkinsonimus, Alzheimerova choroba. - Interpretace různých typů studií z pohledu statistika: real-world data, klinické studie, metaanalýza. Co vše ovlivňuje interpretaci dat. Příklady z oblasti pneumologie a onkologie. - Toxické látky v ovzduší a cigaretovém kouři. Vliv kouření na zdraví lidského organismu s ohledem na rozvoj některých typů onemocnění, zejména plicních, kardiovaskulárních, cukrovky, vybraných nádorů atd., související statistiky a epidemiologické studie, zhodnocení zdravotních rizik, celkové důsledky pro organismus, příklady recentních studií. - Příčiny vzniku a rozvoje závažných onemocnění. Typy studií působení faktorů ovlivňujících zdraví. Závažná onemocnění a životní styl (škodlivé a preventivní faktory). Faktory ovlivňující vznik nádorů. Potrava a výživa, vztah ke zdraví a nemoci, nutrigenomika, farmakogenomika, inovativní technologie. Rovnováha příjmu a výdeje kalorií, obezita. Bioaktivní složky potravy. Podpůrné a preventivní faktory. Význam lipidů ve výživě. Biologická úloha lipidů. Vysoce nenasycené mastné kyseliny (VNMK, n-6 vs. n-3). Mechanismy působení VNMK. VNMK a mentální zdraví. Uplatnění poznatků v praxi. - Statistické pojmy běžně se vyskytující v literatuře a veřejně dostupných informačních zdrojích. Jak na ně nahlížet, jak je interpretovat, na co si dát pozor. Význam jednorozměrných a vícerozměrných modelů. Specifika analýzy přežití. - Role mikrobiomu v rozvoji neurologických/neuropatologických poruch a v rozvoji nádorového onemocnění.

Literature

recommended literature
• Food and Health in Europe: a new basis for action, WHO Regional Publications European Series, No. 96, 2006
• Wilhelm Z. a kol., Výživa v onkologii, (Nutrition in oncology) Brno 2004
• ZADÁK, Zdeněk. Výživa v intenzivní péči. 2. rozš. a aktualiz. vyd. Praha: Grada, 2009, 542 s. ISBN 9788024728445. info
• FOŘT, Petr. Co jíme a pijeme? Výživa pro 3. tisícitletí. (What we eat and drink? Nutrition for 3rd millenium) 1. vyd. Praha: Olympia, 2003. 246 s. ISBN 80-7033-814-8.
• Jak vzdorovat rakovině. (How to resist cancer) Edited by Olga Dostálová. [1. vyd.]. Praha: Grada-Avicenum, 1993. 205 s. ISBN 80-7169-040-6.
• Free radicals, aging, and degenerative diseases (Eds. J. E. Johnson, Jr., R. Walford, D. Harman, J. Miquel), Alan. R. Liss, Inc., New York 1986
• Speciální vybraná reviews a vědecké články (Thematic reviews and research papers)

Teaching methods

Basic lectures by teachers and associated discussion. Study of selected research topics and their presentation by students with class discussion.

Assessment methods

Attendance of the lectures is not mandatory but recommended for understanding the topics, discussion with other students and creating and expression student's own opinion. Prerequisite for the course completion is preparation of short presentation for class colleagues and discussion of assigned topic. The final examination is based on written exam evaluated by the teacher.

Language of instruction

Czech

Follow-Up Courses

• Bi7070 Physiology of Cell Systems
• Bi8110 Mechanisms of carcinogenesis

Further comments (probably available only in Czech)

The course is taught annually.
Information on course enrolment limitations: Na předmět se vztahuje povinnost registrace, bez registrace může být znemožněn zápis předmětu!

Bi6871 Health Risks

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

doc. RNDr. Alena Hyršlová Vaculová, Ph.D. (lecturer)
prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)
Mgr. Jiřina Procházková, Ph.D. (lecturer)
Mgr. Petra Ovesná, Ph.D. (lecturer)

Guaranteed by

doc. RNDr. Alena Hyršlová Vaculová, Ph.D.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: doc. RNDr. Alena Hyršlová Vaculová, Ph.D.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science

Timetable

Thu 10:00–11:50 B11/333

Prerequisites

Required basic knowledge of biochemistry, cellular physiology and molecular biology. Associated with lectures of Physiology of cell systems and Mechanisms of carcinogenesis.

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 6 fields of study the course is directly associated with, display

Course objectives

The aim of the course is to acquaint students with the information about causes of the development of selected disorders and diseases, especially so-called civilization diseases, such as cancer, inflammation, allergies, stress, lung, liver and cardiovascular diseases, neurological and psychological disorders, including approaches and methods of their research, and selected epidemiology studies. It is focused especially on the impact of environmental factors (chemical and biological) on human health, the role of diet, lifestyle, and the use of knowledge in the prevention of diseases. Students will also learn about the existence and regulation of the body as a hierarchical system, essential processes necessary to maintain its normal functions, and factors that may interfere with these functions.

Learning outcomes

At the end of the course students should be able to: recognize the most important chemical and biological environmental factors and their impacts on human health at the level of specific organs as well as organisms as a whole, including possibilities of disease prevention; describe specific dietary factors and their association with etiology of some serious so-called civilization diseases, such as cardiovascular diseases, cancer, allergies or stress; understand the view of the organism as a hierarchical system and what are the basic processes necessary for maintenance of its homeostasis; interpret and use knowledge of environmental factors influencing human health and of possibilities of disease prevention; explain recent results of epidemiologic and scientific studies of given topic; learn the ability to elaborate and present assigned topic.

Syllabus

• - Úloha faktorů vnějšího prostředí v rozvoji jaterních onemocnění. Toxické látky, alkohol, vybrané složky výživy, virová hepatitida, životní styl atd. a jejich vliv na rozvoj nádorů jater a některých chronických onemocnění jater, související statistiky a epidemiologické studie. Poškození jater jako centrálního orgánu metabolismu a jeho dopad na celkový zdravotní stav organismu, příklady recentních studií, zhodnocení zdravotních rizik. - Environmentální faktory vyvolávající či přispívající ke vzniku fenoménu vývojové a chronické neurotoxicity. Chemické i biologické faktory, které se mohou běžně vyskytovat v našem prostředí a podílet se na vzniku a rozvoji neurologických poruch u dětí a starších osob. Jejich původ, způsoby expozice, epidemiologické studie prokazující jejich chronický a kumulativní účinek. Neurologická onemocnění a poruchy soustředění, narušení kognitivních funkcí, autismus, ADHD, Parkinsonova choroba vs. parkinsonimus, Alzheimerova choroba. - Interpretace různých typů studií z pohledu statistika: real-world data, klinické studie, metaanalýza. Co vše ovlivňuje interpretaci dat. Příklady z oblasti pneumologie a onkologie. - Toxické látky v ovzduší a cigaretovém kouři. Vliv kouření na zdraví lidského organismu s ohledem na rozvoj některých typů onemocnění, zejména plicních, kardiovaskulárních, cukrovky, vybraných nádorů atd., související statistiky a epidemiologické studie, zhodnocení zdravotních rizik, celkové důsledky pro organismus, příklady recentních studií. - Příčiny vzniku a rozvoje závažných onemocnění. Typy studií působení faktorů ovlivňujících zdraví. Závažná onemocnění a životní styl (škodlivé a preventivní faktory). Faktory ovlivňující vznik nádorů. Potrava a výživa, vztah ke zdraví a nemoci, nutrigenomika, farmakogenomika, inovativní technologie. Rovnováha příjmu a výdeje kalorií, obezita. Bioaktivní složky potravy. Podpůrné a preventivní faktory. Význam lipidů ve výživě. Biologická úloha lipidů. Vysoce nenasycené mastné kyseliny (VNMK, n-6 vs. n-3). Mechanismy působení VNMK. VNMK a mentální zdraví. Uplatnění poznatků v praxi. - Statistické pojmy běžně se vyskytující v literatuře a veřejně dostupných informačních zdrojích. Jak na ně nahlížet, jak je interpretovat, na co si dát pozor. Význam jednorozměrných a vícerozměrných modelů. Specifika analýzy přežití. - Role mikrobiomu v rozvoji neurologických/neuropatologických poruch a v rozvoji nádorového onemocnění.

Literature

recommended literature
• Food and Health in Europe: a new basis for action, WHO Regional Publications European Series, No. 96, 2006
• Wilhelm Z. a kol., Výživa v onkologii, (Nutrition in oncology) Brno 2004
• ZADÁK, Zdeněk. Výživa v intenzivní péči. 2. rozš. a aktualiz. vyd. Praha: Grada, 2009, 542 s. ISBN 9788024728445. info
• FOŘT, Petr. Co jíme a pijeme? Výživa pro 3. tisícitletí. (What we eat and drink? Nutrition for 3rd millenium) 1. vyd. Praha: Olympia, 2003. 246 s. ISBN 80-7033-814-8.
• Jak vzdorovat rakovině. (How to resist cancer) Edited by Olga Dostálová. [1. vyd.]. Praha: Grada-Avicenum, 1993. 205 s. ISBN 80-7169-040-6.
• Free radicals, aging, and degenerative diseases (Eds. J. E. Johnson, Jr., R. Walford, D. Harman, J. Miquel), Alan. R. Liss, Inc., New York 1986
• Speciální vybraná reviews a vědecké články (Thematic reviews and research papers)

Teaching methods

Basic lectures by teachers and associated discussion. Study of selected research topics and their presentation by students with class discussion.

Assessment methods

Attendance of the lectures is not mandatory but recommended for understanding the topics, discussion with other students and creating and expression student's own opinion. Prerequisite for the course completion is preparation of short presentation for class colleagues and discussion of assigned topic. The final examination is based on written exam evaluated by the teacher. Students must answer minimally 50percent of questions covering the topics presented in the lectures.

Language of instruction

Czech

Follow-Up Courses

• Bi7070 Physiology of Cell Systems
• Bi8110 Mechanisms of carcinogenesis

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.
Information on course enrolment limitations: Na předmět se vztahuje povinnost registrace, bez registrace může být znemožněn zápis předmětu!

Bi6871 Health Risks

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

doc. RNDr. Alena Hyršlová Vaculová, Ph.D. (lecturer)
prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)
Mgr. Jiřina Procházková, Ph.D. (lecturer)
Mgr. Petra Ovesná, Ph.D. (lecturer)

Guaranteed by

doc. RNDr. Alena Hyršlová Vaculová, Ph.D.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: doc. RNDr. Alena Hyršlová Vaculová, Ph.D.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science

Timetable

Wed 8:00–9:50 B11/333

Prerequisites

Required basic knowledge of biochemistry, cellular physiology and molecular biology. Associated with lectures of Physiology of cell systems and Mechanisms of carcinogenesis.

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 6 fields of study the course is directly associated with, display

Course objectives

The aim of the course is to acquaint students with the information about causes of the development of selected disorders and diseases, especially so-called civilization diseases, such as cancer, inflammation, allergies, stress, lung, liver and cardiovascular diseases, neurological and psychological disorders, including approaches and methods of their research, and selected epidemiology studies. It is focused especially on the impact of environmental factors (chemical and biological) on human health, the role of diet, lifestyle, and the use of knowledge in the prevention of diseases. Students will also learn about the existence and regulation of the body as a hierarchical system, essential processes necessary to maintain its normal functions, and factors that may interfere with these functions.

Learning outcomes

At the end of the course students should be able to: recognize the most important chemical and biological environmental factors and their impacts on human health at the level of specific organs as well as organisms as a whole, including possibilities of disease prevention; describe specific dietary factors and their association with etiology of some serious so-called civilization diseases, such as cardiovascular diseases, cancer, allergies or stress; understand the view of the organism as a hierarchical system and what are the basic processes necessary for maintenance of its homeostasis; interpret and use knowledge of environmental factors influencing human health and of possibilities of disease prevention; explain recent results of epidemiologic and scientific studies of given topic; learn the ability to elaborate and present assigned topic.

Syllabus

• - Causes of initiation and promotion of civilization diseases - genetic predisposition, non-genetic causes. Type of studies (epidemiological, clinical, and experimental studies, population screening), incidence of cancer and other diseases (in the Czech Republic, in the world), information sources - yearbook of health in ČR, SVOD, NOR. Problems of specific types of studies. Carcinogenesis - main cancer promotion factors, genetic and non-genetic factors, endogenous factors - the role of hormones. Civilization diseases and lifestyle. - Diet - energy balance, dietary lipids – fibre and butyrate, essential polyunsaturated fatty acids and their impact on human health and (cardiovascular diseases, foetal development, depressions and neurodegenerative diseases, cancer). Epidemiological and experimental studies. - Chemoprevention, therapy, paliative treatments, predictive onkology – detection of specific parameters, comparison of methods and interpretation of results. - The role of environmental factors in the development of pulmonary diseases. Toxic agents in the air and cigarette smoke. Smoking and the human health and disease, especially lung cancer and selected chronic pulmonary diseases; related statistics and epidemiology studies, health risk assessments. Epigenetic changes induced by smoking and their role in carcinogenesis, overall impact on human health, examples of recent studies. - The role of environmental factors in the development of liver diseases. Toxic chemicals, alcohol, selected dietary factors, viral hepatitis etc., and their role in the development of liver cancer and selected chronic liver diseases; related statistics and epidemiology studies. Liver damage and its overall impact on human health, examples of recent studies, health risk assessments. - Environmental factors associated with the developmental and chronic neurotoxicity. Emerging/ chronic chemical and biological factors commonly present in our environment and contributing to higher prevalence of neurological impairments and disorders in children and elders. Sources, types of exposures, epidemiological studies showing deleterious effects induced by their chronic and cummulative character. Neurological diseases and deficits, cognitive functions disorders, hyperactivity disorders and learning deficits, autism, ADHD, Parkinson disease vs. parkinsonims, Alzheimer disease, depression. - Environmental factors underlying development and/or transgenerational transmission of oncogenic mutations. Oncogenic viruses, the roles bacterias play in oncogenesis. - The role of microbiota in the development of neurological/ neuropathological and cancer diseases. - Homeostasis, health and disease - basic terms, short introduction. Negative and positive feedback - significance for homeostasis, homeostasis on the cell, tissue and system levels. Organism as hierarchic system, cooperation of nervous, endocrine and humoral systems.. Stressas a model example, its causes and consequences. Prevention of functional damage of organism and diseases vs. selected therapeutic possibilities.

Literature

recommended literature
• Food and Health in Europe: a new basis for action, WHO Regional Publications European Series, No. 96, 2006
• Wilhelm Z. a kol., Výživa v onkologii, (Nutrition in oncology) Brno 2004
• ZADÁK, Zdeněk. Výživa v intenzivní péči. 2. rozš. a aktualiz. vyd. Praha: Grada, 2009, 542 s. ISBN 9788024728445. info
• FOŘT, Petr. Co jíme a pijeme? Výživa pro 3. tisícitletí. (What we eat and drink? Nutrition for 3rd millenium) 1. vyd. Praha: Olympia, 2003. 246 s. ISBN 80-7033-814-8.
• Jak vzdorovat rakovině. (How to resist cancer) Edited by Olga Dostálová. [1. vyd.]. Praha: Grada-Avicenum, 1993. 205 s. ISBN 80-7169-040-6.
• Free radicals, aging, and degenerative diseases (Eds. J. E. Johnson, Jr., R. Walford, D. Harman, J. Miquel), Alan. R. Liss, Inc., New York 1986
• Speciální vybraná reviews a vědecké články (Thematic reviews and research papers)

Teaching methods

Basic lectures by teachers and associated discussion. Study of selected research topics and their presentation by students with class discussion.

Assessment methods

Attendance of the lectures is not mandatory but recommended for understanding the topics, discussion with other students and creating and expression student's own opinion. Prerequisite for the course completion is preparation of short presentation for class colleagues and discussion of assigned topic. The final examination is based on written exam evaluated by the teacher. Students must answer minimally 50percent of questions covering the topics presented in the lectures.

Language of instruction

Czech

Follow-Up Courses

• Bi7070 Physiology of Cell Systems
• Bi8110 Mechanisms of carcinogenesis

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.
Information on course enrolment limitations: Na předmět se vztahuje povinnost registrace, bez registrace může být znemožněn zápis předmětu!

Bi6871 Health Risks

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)
doc. RNDr. Alena Hyršlová Vaculová, Ph.D. (lecturer)
prof. RNDr. Alois Kozubík, CSc. (lecturer)
Mgr. Jiřina Procházková, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Jiřina Hofmanová, CSc.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science

Timetable

Mon 1. 3. to Fri 14. 5. Thu 9:00–10:50 online_B3

Prerequisites

SOUHLAS
Required basic knowledge of biochemistry, cellular physiology and molecular biology. Associated with lectures of Physiology of cell systems and Mechanisms of carcinogenesis.

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 6 fields of study the course is directly associated with, display

Course objectives

The aim of the course is to acquaint students with the information about causes of the development of selected disorders and diseases, especially so-called civilization diseases, such as cancer, inflammation, allergies, stress, lung, liver and cardiovascular diseases, neurological and psychological disorders, including approaches and methods of their research, and selected epidemiology studies. It is focused especially on the impact of environmental factors (chemical and biological) on human health, the role of diet, lifestyle, and the use of knowledge in the prevention of diseases. Students will also learn about the existence and regulation of the body as a hierarchical system, essential processes necessary to maintain its normal functions, and factors that may interfere with these functions.

Learning outcomes

At the end of the course students should be able to: recognize the most important chemical and biological environmental factors and their impacts on human health at the level of specific organs as well as organisms as a whole, including possibilities of disease prevention; describe specific dietary factors and their association with etiology of some serious so-called civilization diseases, such as cardiovascular diseases, cancer, allergies or stress; understand the view of the organism as a hierarchical system and what are the basic processes necessary for maintenance of its homeostasis; interpret and use knowledge of environmental factors influencing human health and of possibilities of disease prevention; explain recent results of epidemiologic and scientific studies of given topic; learn the ability to elaborate and present assigned topic.

Syllabus

• - Causes of initiation and promotion of civilization diseases - genetic predisposition, non-genetic causes. Type of studies (epidemiological, clinical, and experimental studies, population screening), incidence of cancer and other diseases (in the Czech Republic, in the world), information sources - yearbook of health in ČR, SVOD, NOR. Problems of specific types of studies. Carcinogenesis - main cancer promotion factors, genetic and non-genetic factors, endogenous factors - the role of hormones. Civilization diseases and lifestyle. - Diet - energy balance, dietary lipids – fibre and butyrate, essential polyunsaturated fatty acids and their impact on human health and (cardiovascular diseases, foetal development, depressions and neurodegenerative diseases, cancer). Epidemiological and experimental studies. - Chemoprevention, therapy, paliative treatments, predictive onkology – detection of specific parameters, comparison of methods and interpretation of results. - The role of environmental factors in the development of pulmonary diseases. Toxic agents in the air and cigarette smoke. Smoking and the human health and disease, especially lung cancer and selected chronic pulmonary diseases; related statistics and epidemiology studies, health risk assessments. Epigenetic changes induced by smoking and their role in carcinogenesis, overall impact on human health, examples of recent studies. - The role of environmental factors in the development of liver diseases. Toxic chemicals, alcohol, selected dietary factors, viral hepatitis etc., and their role in the development of liver cancer and selected chronic liver diseases; related statistics and epidemiology studies. Liver damage and its overall impact on human health, examples of recent studies, health risk assessments. - Environmental factors associated with the developmental and chronic neurotoxicity. Emerging/ chronic chemical and biological factors commonly present in our environment and contributing to higher prevalence of neurological impairments and disorders in children and elders. Sources, types of exposures, epidemiological studies showing deleterious effects induced by their chronic and cummulative character. Neurological diseases and deficits, cognitive functions disorders, hyperactivity disorders and learning deficits, autism, ADHD, Parkinson disease vs. parkinsonims, Alzheimer disease, depression. - Environmental factors underlying development and/or transgenerational transmission of oncogenic mutations. Oncogenic viruses, the roles bacterias play in oncogenesis. - The role of microbiota in the development of neurological/ neuropathological and cancer diseases. - Homeostasis, health and disease - basic terms, short introduction. Negative and positive feedback - significance for homeostasis, homeostasis on the cell, tissue and system levels. Organism as hierarchic system, cooperation of nervous, endocrine and humoral systems.. Stressas a model example, its causes and consequences. Prevention of functional damage of organism and diseases vs. selected therapeutic possibilities.

Literature

recommended literature
• Food and Health in Europe: a new basis for action, WHO Regional Publications European Series, No. 96, 2006
• Wilhelm Z. a kol., Výživa v onkologii, (Nutrition in oncology) Brno 2004
• ZADÁK, Zdeněk. Výživa v intenzivní péči. 2. rozš. a aktualiz. vyd. Praha: Grada, 2009, 542 s. ISBN 9788024728445. info
• FOŘT, Petr. Co jíme a pijeme? Výživa pro 3. tisícitletí. (What we eat and drink? Nutrition for 3rd millenium) 1. vyd. Praha: Olympia, 2003. 246 s. ISBN 80-7033-814-8.
• Jak vzdorovat rakovině. (How to resist cancer) Edited by Olga Dostálová. [1. vyd.]. Praha: Grada-Avicenum, 1993. 205 s. ISBN 80-7169-040-6.
• Free radicals, aging, and degenerative diseases (Eds. J. E. Johnson, Jr., R. Walford, D. Harman, J. Miquel), Alan. R. Liss, Inc., New York 1986
• Speciální vybraná reviews a vědecké články (Thematic reviews and research papers)

Teaching methods

Basic lectures by teachers and associated discussion. Study of selected research topics and their presentation by students with class discussion.

Assessment methods

Attendance of the lectures is not mandatory but recommended for understanding the topics, discussion with other students and creating and expression student's own opinion. Prerequisite for the course completion is preparation of short presentation for class colleagues and discussion of assigned topic. The final examination is based on written exam evaluated by the teacher. Students must answer minimally 50percent of questions covering the topics presented in the lectures.

Language of instruction

Czech

Follow-Up Courses

• Bi7070 Physiology of Cell Systems
• Bi8110 Mechanisms of carcinogenesis

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.
Information on course enrolment limitations: V období jaro 2021 je předmět vypisován primárně studentům, kteří jej mají ve studijním plánu jako povinný. Na předmět se vztahuje povinnost registrace, bez registrace může být znemožněn zápis předmětu!

Bi6871 Health Risks

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)
doc. RNDr. Alena Hyršlová Vaculová, Ph.D. (lecturer)
prof. RNDr. Alois Kozubík, CSc. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Jiřina Hofmanová, CSc.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science

Timetable

Thu 10:00–11:50 D36/215

Prerequisites

Required basic knowledge of biochemistry, cellular physiology and molecular biology. Associated with lectures of Physiology of cell systems and Mechanisms of carcinogenesis.

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 6 fields of study the course is directly associated with, display

Course objectives

The aim of the course is to acquaint students with the causes of the development of selected disorders and diseases, especially so called civilization diseases, such as cardiovascular, cancer, inflammation, allergies, stress and psychological disorders, including approaches and methods of their research. It is focused especially to the impact of environmental factors on human health with an emphasis on the role of lifestyle, environment and specific nutrients and the use of knowledge in the prevention of diseases. Students will also learn about the existence and regulation of the body as a hierarchical system, essential processes necessary to maintain its normal functions, and factors that may interfere with these functions.

Learning outcomes

At the end of the course students should be able to: recognize the most harmful environmental factors and their impacts on human health including possibilities of disease prevention; describe specific dietary factors and their association with etiology of some serious so-called civilization diseases, such as cardiovascular diseases, cancer, allergies or stress; understand the view of the organism as a hierarchical system and what are the basic processes necessary for maintenance of its homeostasis; interpret and use knowledge of environmental factors influencing human health and of possibilities of disease prevention; explain recent results of epidemiologic and scientific studies of given topic; learn the ability to elaborate and present assigned topic.

Syllabus

• Causes of initiation and promotion of civilization diseases - genetic predisposition, life style. Type of studies (epidemiological, clinical, and experimental studies, population screening ), occurrence of cancer (in the Czech Republic, in the world), source of information - yearbook of health in ČR, SVOD, NOR. Problems of specific types of studies. Carcinogenesis - main cancer promotion factors, genetic and non-genetic factors, endogenous factors - the role of hormones. Cardiovascular diseases, carcinogenesis and life style (smoking, diet, physical activities). Harmful environmental factors - radiation (ionizing, non-ionizing), chemicals and xenobiotics (heavy metals, aromatic hydrocarbons, PCBs, dioxins, pesticides, drugs etc.). Diet - energy balance, effects of high-glycide and high-fat diets, specific dietary lipids – fibre and butyrate, fatty acids, n-3 and n-6 polyunsaturated fatty acids and their importance for health (cardiovascular diseases, foetal development, depression and neurodegenerative diseases, cancer). Fruits and vegetables and other beneficial food components. Chemoprevention - risk assessment, targets for decrease of risk and mortality, anticancer factors. Contemporary system of detection of carcinogenic effects of compounds; Genotoxicity (mutagenic effects) – mutagenicity tests; Problems of detection of non-genotoxic carcinogens; long-term test with laboratory animals, alternative short-term tests - transformation test, changes of proliferation and apoptosis in tissues, GJIC changes, detection of specific biomarkers (specific cell enzyme and receptors activities); Models of carcinogenesis - studies of initiation and promotion effects - skin, liver, bladder, kidney; causes of different sensitivity of cells, tissues and organisms to carcinogens; Risk assessment - dose-response curves, threshold values, the effects of mixture of compounds (additivity, synergism, antagonism). Importance of experimental ecotoxicology - perspectives, association with experimental and predictive oncology. Prevention, diagnostics and treatment of cancer. Experimental, epidemiologic and clinical studies, population screening, diagnostic markers. Therapy, paliative care; Predictive oncology - detection of specific markers, comparison of methods and interpretation of measured parameters, data management and data interpretation - significance of multidimensional statistical analyses. Homeostasis, health and disease - basic terms, short introduction to the theory of systems. Negative and positive feedback - significance for homeostasis, homeostasis on the cell, tissue and system levels. Organism as hierarchic system, cooperation of nervous, endocrine and humoral systems. Causes of cardiovascular diseases. Causes of allergy and inflammation. Stress - causes and consequences. Prevention of functional damage and diseases vs. therapeutic possibilities.

Literature

recommended literature
• Food and Health in Europe: a new basis for action, WHO Regional Publications European Series, No. 96, 2006
• Wilhelm Z. a kol., Výživa v onkologii, (Nutrition in oncology) Brno 2004
• ZADÁK, Zdeněk. Výživa v intenzivní péči. 2. rozš. a aktualiz. vyd. Praha: Grada, 2009, 542 s. ISBN 9788024728445. info
• FOŘT, Petr. Co jíme a pijeme? Výživa pro 3. tisícitletí. (What we eat and drink? Nutrition for 3rd millenium) 1. vyd. Praha: Olympia, 2003. 246 s. ISBN 80-7033-814-8.
• Jak vzdorovat rakovině. (How to resist cancer) Edited by Olga Dostálová. [1. vyd.]. Praha: Grada-Avicenum, 1993. 205 s. ISBN 80-7169-040-6.
• Free radicals, aging, and degenerative diseases (Eds. J. E. Johnson, Jr., R. Walford, D. Harman, J. Miquel), Alan. R. Liss, Inc., New York 1986
• Speciální vybraná reviews a vědecké články (Thematic reviews and research papers)

Teaching methods

Basic lectures by teachers and associated discussion. Study of own selected research topic and its presentation with class discussion.

Assessment methods

Attendance of the lectures is not mandatory but recommended for understanding the topics, discussion with other students and creating and expression student's own opinion. Prerequisite for the course completion is preparation of about 10 min presentation for class colleagues and discussion of assigned topic. The final examination is based on written exam evaluated by the teacher. Students must answer minimally 10 from 20 questions covering the topics presented in the lectures.

Language of instruction

Czech

Follow-Up Courses

• Bi7070 Physiology of Cell Systems
• Bi8110 Mechanisms of carcinogenesis

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.
Information on course enrolment limitations: Na předmět se vztahuje povinnost registrace, bez registrace může být znemožněn zápis předmětu!

Bi6871 Health Risks

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)
doc. RNDr. Alena Hyršlová Vaculová, Ph.D. (lecturer)
prof. RNDr. Alois Kozubík, CSc. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Jiřina Hofmanová, CSc.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science

Timetable

Mon 18. 2. to Fri 17. 5. Thu 11:00–12:50 D36/215

Prerequisites

Connected with lectures of Physiology of cell systems and Mechanisms of carcinogenesis

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

• General Biology (programme PřF, N-BI, specialization Ekotoxikologie)
• Special Biology (programme PřF, N-EXB)
• Special Biology (programme PřF, N-EXB, specialization Ekotoxikologie)

Course objectives

The aim of the subject is to acquaint students with the causes of the development of selected disorders and diseases, especially so called civilization diseases, such as cardiovascular, cancer, inflammation, allergies, stress and psychological disorders, including approaches and methods of their research. In particular, the impact of environmental factors on human health with an emphasis on the role of lifestyle, environment and specific nutrients and the use of knowledge in the prevention of diseases. Students will also learn about the existence and regulation of the body as a hierarchical system, essential processes necessary to maintain its normal functions, and factors that may interfere with these functions.

Learning outcomes

At the end of the course students should be able to: recognize the most harmful environmental factors and their impacts on human health including possibilities of disease prevention; describe specific dietary factors and their association with etiology of some serious so-called civilization diseases, such as cardiovascular diseases, cancer, allergies or stress; understand the view of the organism as a hierarchical system and what are the basic processes necessary for maintenance of its homeostasis; interpret and use knowledge of environmental factors influencing human health and of possibilities of disease prevention; explain recent results of epidemiologic and scientific studies of given topic; learn the ability to elaborate and present assigned topic.

Syllabus

• Causes of initiation and promotion of civilization diseases - genetic predisposition, life style. Type of studies (epidemiological, clinical, and experimental studies, population screening ), occurrence of cancer (in the Czech Republic, in the world).
• Carcinogenesis - main cancer promotion factors, genetic and non-genetic factors, endogenous factors - the role of hormones.
• Carcinogenesis and life style (smoking, diet, physical activities).
• Harmful environmental factors - radiation (ionizing, non-ionizing), chemicals and xenobiotics (heavy metals, aromatic hydrocarbons, PCBs, dioxins, pesticides, drugs etc.).
• Diet - energy balance, effects of high-glycide and high-fat diets, specific dietary lipids - butyrate, essential fatty acids.
• Chemoprevention - risk assessment, targets for decrease of risk and mortality, anticancer factors.
• Prevention, diagnostics and treatment of cancer.
• Experimental, epidemiologic and clinical studies, population screening, diagnostic markers.
• Therapy - surgery, radiation, chemotherapy, immunotherapy.
• Predictive oncology - detection of specific markers, comparison of methods and interpretation of measured parameters, data management and data interpretation - significance of multidimensional statistical analyses, predictive markers.
• Homeostasis, health and disease - basic terms, short introduction to the theory of systems.
• Negative and positive feedback - significance for homeostasis, homeostasis on the cell, tissue and system levels.
• Organism as hierarchic system, cooperation of nervous, endocrine and humoral systems.
• Causes of cardiovascular diseases.
• Causes of allergy and inflammation.
• Stress - causes and consequences.
• Prevention of functional damage and diseases vs. therapeutic possibilities.

Literature

recommended literature
• Food and Health in Europe: a new basis for action, WHO Regional Publications European Series, No. 96, 2006
• Wilhelm Z. a kol., Výživa v onkologii, (Nutrition in oncology) Brno 2004
• ZADÁK, Zdeněk. Výživa v intenzivní péči. 2. rozš. a aktualiz. vyd. Praha: Grada, 2009, 542 s. ISBN 9788024728445. info
• FOŘT, Petr. Co jíme a pijeme? Výživa pro 3. tisícitletí. (What we eat and drink? Nutrition for 3rd millenium) 1. vyd. Praha: Olympia, 2003. 246 s. ISBN 80-7033-814-8.
• Jak vzdorovat rakovině. (How to resist cancer) Edited by Olga Dostálová. [1. vyd.]. Praha: Grada-Avicenum, 1993. 205 s. ISBN 80-7169-040-6.
• Free radicals, aging, and degenerative diseases (Eds. J. E. Johnson, Jr., R. Walford, D. Harman, J. Miquel), Alan. R. Liss, Inc., New York 1986
• Speciální vybraná reviews a vědecké články (Thematic reviews and research papers)

Teaching methods

Basic lectures by teachers and associated discussion. Study of own selected research topic and its presentation with class discussion.

Assessment methods

Attendance of the lectures is not mandatory but recommended for understanding the topics, discussion with other students and creating and expression student's own opinion. Prerequisite for the course completion is preparation of about 10 min presentation for class colleagues and discussion of assigned topic. The final examination is based on written exam evaluated by the teacher. Students must answer minimally 6 from 10 questions covering the topics presented in the lectures.

Language of instruction

Czech

Follow-Up Courses

• Bi7070 Physiology of Cell Systems
• Bi8110 Mechanisms of carcinogenesis

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.
Information on course enrolment limitations: Na předmět se vztahuje povinnost registrace, bez registrace může být znemožněn zápis předmětu!

Bi6871 Health Risks

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)
prof. RNDr. Alois Kozubík, CSc. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Jiřina Hofmanová, CSc.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science

Timetable

Thu 10:00–11:50 D36/215

Prerequisites

Connected with lectures of Physiology of cell systems and Mechanisms of carcinogenesis

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

• General Biology (programme PřF, N-BI, specialization Ekotoxikologie)
• Special Biology (programme PřF, N-EXB)
• Special Biology (programme PřF, N-EXB, specialization Ekotoxikologie)

Course objectives

The aim of the subject is to acquaint students with the causes of the development of selected disorders and diseases, especially so called civilization diseases, such as cardiovascular, cancer, inflammation, allergies, stress and psychological disorders, including approaches and methods of their research. In particular, the impact of environmental factors on human health with an emphasis on the role of lifestyle, environment and specific nutrients and the use of knowledge in the prevention of diseases. Students will also learn about the existence and regulation of the body as a hierarchical system, essential processes necessary to maintain its normal functions, and factors that may interfere with these functions.

Learning outcomes

At the end of the course students should be able to: recognize the most harmful environmental factors and their impacts on human health including possibilities of disease prevention; describe specific dietary factors and their association with etiology of some serious so-called civilization diseases, such as cardiovascular diseases, cancer, allergies or stress; understand the view of the organism as a hierarchical system and what are the basic processes necessary for maintenance of its homeostasis; interpret and use knowledge of environmental factors influencing human health and of possibilities of disease prevention; explain recent results of epidemiologic and scientific studies of given topic; learn the ability to elaborate and present assigned topic.

Syllabus

• Causes of initiation and promotion of civilization diseases - genetic predisposition, life style. Type of studies (epidemiological, clinical, and experimental studies, population screening ), occurrence of cancer (in the Czech Republic, in the world).
• Carcinogenesis - main cancer promotion factors, genetic and non-genetic factors, endogenous factors - the role of hormones.
• Carcinogenesis and life style (smoking, diet, physical activities).
• Harmful environmental factors - radiation (ionizing, non-ionizing), chemicals and xenobiotics (heavy metals, aromatic hydrocarbons, PCBs, dioxins, pesticides, drugs etc.).
• Diet - energy balance, effects of high-glycide and high-fat diets, specific dietary lipids - butyrate, essential fatty acids.
• Chemoprevention - risk assessment, targets for decrease of risk and mortality, anticancer factors.
• Prevention, diagnostics and treatment of cancer.
• Experimental, epidemiologic and clinical studies, population screening, diagnostic markers.
• Therapy - surgery, radiation, chemotherapy, immunotherapy.
• Predictive oncology - detection of specific markers, comparison of methods and interpretation of measured parameters, data management and data interpretation - significance of multidimensional statistical analyses, predictive markers.
• Homeostasis, health and disease - basic terms, short introduction to the theory of systems.
• Negative and positive feedback - significance for homeostasis, homeostasis on the cell, tissue and system levels.
• Organism as hierarchic system, cooperation of nervous, endocrine and humoral systems.
• Causes of cardiovascular diseases.
• Causes of allergy and inflammation.
• Stress - causes and consequences.
• Prevention of functional damage and diseases vs. therapeutic possibilities.

Literature

recommended literature
• Food and Health in Europe: a new basis for action, WHO Regional Publications European Series, No. 96, 2006
• Wilhelm Z. a kol., Výživa v onkologii, (Nutrition in oncology) Brno 2004
• ZADÁK, Zdeněk. Výživa v intenzivní péči. 2. rozš. a aktualiz. vyd. Praha: Grada, 2009, 542 s. ISBN 9788024728445. info
• FOŘT, Petr. Co jíme a pijeme? Výživa pro 3. tisícitletí. (What we eat and drink? Nutrition for 3rd millenium) 1. vyd. Praha: Olympia, 2003. 246 s. ISBN 80-7033-814-8.
• Jak vzdorovat rakovině. (How to resist cancer) Edited by Olga Dostálová. [1. vyd.]. Praha: Grada-Avicenum, 1993. 205 s. ISBN 80-7169-040-6.
• Free radicals, aging, and degenerative diseases (Eds. J. E. Johnson, Jr., R. Walford, D. Harman, J. Miquel), Alan. R. Liss, Inc., New York 1986
• Speciální vybraná reviews a vědecké články (Thematic reviews and research papers)

Teaching methods

Basic lectures by teachers and associated discussion. Study of own selected research topic and its presentation with class discussion.

Assessment methods

Attendance of the lectures is not mandatory but recommended for understanding the topics, discussion with other students and creating and expression student's own opinion. Prerequisite for the course completion is preparation of about 10 min presentation for class colleagues and discussion of assigned topic. The final examination is based on written exam evaluated by the teacher. Students must answer minimally 6 from 10 questions covering the topics presented in the lectures.

Language of instruction

Czech

Follow-Up Courses

• Bi7070 Physiology of Cell Systems
• Bi8110 Mechanisms of carcinogenesis

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.
Information on course enrolment limitations: Na předmět se vztahuje povinnost registrace, bez registrace může být znemožněn zápis předmětu!

Bi6871 Health Risks

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: graded credit.

Teacher(s)

prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)
prof. RNDr. Alois Kozubík, CSc. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Jiřina Hofmanová, CSc.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science

Timetable

Thu 12:00–13:50 D36/215

Prerequisites

Connected with lectures of Physiology of cell systems and Genotoxicity and carcinogenesis

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

• General Biology (programme PřF, N-BI, specialization Ekotoxikologie)
• Special Biology (programme PřF, N-EXB)
• Special Biology (programme PřF, N-EXB, specialization Ekotoxikologie)

Course objectives

At the end of the course students should be able to: recognize the most harmful environmental factors and their impacts on human health including possibilities of disease prevention; describe specific dietary factors (especially of lipid character) and their association with etiology of some serious so-called civilization diseases, such as cardiovascular diseases, cancer, allergies or stress; understand the view of the organism as a hierarchical system and what are the basic processes necessary for maintenance of its homeostasis; interpret and use knowledge of environmental factors (especially dietary) influencing human health and of possibilities of disease prevention; explain recent results of epidemiologic and scientific studies of given topic; learn the ability to elaborate and present assigned topic.

Syllabus

• Causes of initiation and promotion of civilization diseases - genetic predisposition, life style. Type of studies (epidemiological, clinical, and experimental studies, population screening ), occurrence of cancer (in the Czech Republic, in the world).
• Carcinogenesis - main cancer promotion factors, genetic and non-genetic factors, endogenous factors - the role of hormones.
• Carcinogenesis and life style (smoking, diet, physical activities).
• Harmful environmental factors - radiation (ionizing, non-ionizing), chemicals and xenobiotics (heavy metals, aromatic hydrocarbons, PCBs, dioxins, pesticides, drugs etc.).
• Diet - energy balance, effects of high-glycide and high-fat diets, specific dietary lipids - butyrate, essential fatty acids.
• Chemoprevention - risk assessment, targets for decrease of risk and mortality, anticancer factors.
• Prevention, diagnostics and treatment of cancer.
• Experimental, epidemiologic and clinical studies, population screening, diagnostic markers.
• Therapy - surgery, radiation, chemotherapy, immunotherapy.
• Predictive oncology - detection of specific markers, comparison of methods and interpretation of measured parameters, data management and data interpretation - significance of multidimensional statistical analyses, predictive markers.
• Homeostasis, health and disease - basic terms, short introduction to the theory of systems.
• Negative and positive feedback - significance for homeostasis, homeostasis on the cell, tissue and system levels.
• Organism as hierarchic system, cooperation of nervous, endocrine and humoral systems.
• Causes of cardiovascular diseases.
• Causes of allergy and inflammation.
• Stress - causes and consequences.
• Prevention of functional damage and diseases vs. therapeutic possibilities.

Literature

recommended literature
• Food and Health in Europe: a new basis for action, WHO Regional Publications European Series, No. 96, 2006
• Wilhelm Z. a kol., Výživa v onkologii, (Nutrition in oncology) Brno 2004
• ZADÁK, Zdeněk. Výživa v intenzivní péči. 2. rozš. a aktualiz. vyd. Praha: Grada, 2009, 542 s. ISBN 9788024728445. info
• FOŘT, Petr. Co jíme a pijeme? Výživa pro 3. tisícitletí. (What we eat and drink? Nutrition for 3rd millenium) 1. vyd. Praha: Olympia, 2003. 246 s. ISBN 80-7033-814-8.
• Jak vzdorovat rakovině. (How to resist cancer) Edited by Olga Dostálová. [1. vyd.]. Praha: Grada-Avicenum, 1993. 205 s. ISBN 80-7169-040-6.
• Free radicals, aging, and degenerative diseases (Eds. J. E. Johnson, Jr., R. Walford, D. Harman, J. Miquel), Alan. R. Liss, Inc., New York 1986
• Speciální vybraná reviews a vědecké články (Thematic reviews and research papers)

Teaching methods

Basic lectures by teachers and associated discussion. Study of own selected research topic and its presentation with class discussion.

Assessment methods

Attendance of the lectures is not mandatory but recommended for understanding the topics, discussion with other students and creating and expression student's own opinion. Prerequisite for the course completion is preparation of about 10 min presentation for class colleagues and discussion of assigned topic. The final examination is based on written exam evaluated by the teacher. Students must answer minimally 6 from 10 questions covering the topics presented in the lectures.

Language of instruction

Czech

Follow-Up Courses

• Bi7070 Physiology of Cell Systems
• Bi8110 Mechanisms of carcinogenesis

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.
Information on course enrolment limitations: POZOR: Ze zdravotních důvodů nebude tento předmět vyučován v semestru jaro 2017! Výjimečně bude přesunut do semestru podzim 2017.

Na předmět se vztahuje povinnost registrace.

Bi6871 Health Risks

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: graded credit.

Teacher(s)

prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)
prof. RNDr. Alois Kozubík, CSc. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Jiřina Hofmanová, CSc.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science

Timetable

Thu 11:00–12:50 D36/215

Prerequisites

Connected with lectures of Physiology of cell systems and Genotoxicity and carcinogenesis

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

• General Biology (programme PřF, N-BI, specialization Ekotoxikologie)
• Special Biology (programme PřF, N-EXB)
• Special Biology (programme PřF, N-EXB, specialization Ekotoxikologie)

Course objectives

At the end of the course students should be able to: recognize the most harmful environmental factors and their impacts on human health including possibilities of disease prevention; describe specific dietary factors (especially of lipid character) and their association with etiology of some serious so-called civilization diseases, such as cardiovascular diseases, cancer, allergies or stress; understand the view of the organism as a hierarchical system and what are the basic processes necessary for maintenance of its homeostasis; interpret and use knowledge of environmental factors (especially dietary) influencing human health and of possibilities of disease prevention; explain recent results of epidemiologic and scientific studies of given topic; learn the ability to elaborate and present assigned topic.

Syllabus

• Causes of initiation and promotion of civilization diseases - genetic predisposition, life style. Type of studies (epidemiological, clinical, and experimental studies, population screening ), occurrence of cancer (in the Czech Republic, in the world).
• Carcinogenesis - main cancer promotion factors, genetic and non-genetic factors, endogenous factors - the role of hormones.
• Carcinogenesis and life style (smoking, diet, physical activities).
• Harmful environmental factors - radiation (ionizing, non-ionizing), chemicals and xenobiotics (heavy metals, aromatic hydrocarbons, PCBs, dioxins, pesticides, drugs etc.).
• Diet - energy balance, effects of high-glycide and high-fat diets, specific dietary lipids - butyrate, essential fatty acids.
• Chemoprevention - risk assessment, targets for decrease of risk and mortality, anticancer factors.
• Prevention, diagnostics and treatment of cancer.
• Experimental, epidemiologic and clinical studies, population screening, diagnostic markers.
• Therapy - surgery, radiation, chemotherapy, immunotherapy.
• Predictive oncology - detection of specific markers, comparison of methods and interpretation of measured parameters, data management and data interpretation - significance of multidimensional statistical analyses, predictive markers.
• Homeostasis, health and disease - basic terms, short introduction to the theory of systems.
• Negative and positive feedback - significance for homeostasis, homeostasis on the cell, tissue and system levels.
• Organism as hierarchic system, cooperation of nervous, endocrine and humoral systems.
• Causes of cardiovascular diseases.
• Causes of allergy and inflammation.
• Stress - causes and consequences.
• Prevention of functional damage and diseases vs. therapeutic possibilities.

Literature

recommended literature
• Food and Health in Europe: a new basis for action, WHO Regional Publications European Series, No. 96, 2006
• Wilhelm Z. a kol., Výživa v onkologii, (Nutrition in oncology) Brno 2004
• ZADÁK, Zdeněk. Výživa v intenzivní péči. 2. rozš. a aktualiz. vyd. Praha: Grada, 2009, 542 s. ISBN 9788024728445. info
• FOŘT, Petr. Co jíme a pijeme? Výživa pro 3. tisícitletí. (What we eat and drink? Nutrition for 3rd millenium) 1. vyd. Praha: Olympia, 2003. 246 s. ISBN 80-7033-814-8.
• Jak vzdorovat rakovině. (How to resist cancer) Edited by Olga Dostálová. [1. vyd.]. Praha: Grada-Avicenum, 1993. 205 s. ISBN 80-7169-040-6.
• Free radicals, aging, and degenerative diseases (Eds. J. E. Johnson, Jr., R. Walford, D. Harman, J. Miquel), Alan. R. Liss, Inc., New York 1986
• Speciální vybraná reviews a vědecké články (Thematic reviews and research papers)

Teaching methods

Basic lectures by teachers and associated discussion. Study of own selected research topic and its presentation with class discussion.

Assessment methods

Attendance of the lectures is not mandatory but recommended for understanding the topics, discussion with other students and creating and expression student's own opinion. Prerequisite for the course completion is preparation of about 10 min presentation for class colleagues and discussion of assigned topic. The final examination is based on written exam evaluated by the teacher. Students must answer minimally 6 from 10 questions covering the topics presented in the lectures.

Language of instruction

Czech

Follow-Up Courses

• Bi7070 Physiology of Cell Systems
• Bi8110 Mechanisms of carcinogenesis

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.
Information on course enrolment limitations: Na předmět se vztahuje povinnost registrace, bez registrace může být znemožněn zápis předmětu!

Bi6871 Health Risks

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: graded credit.

Teacher(s)

prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)
prof. RNDr. Alois Kozubík, CSc. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Jiřina Hofmanová, CSc.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science

Timetable

Tue 10:00–11:50 D36/212

Prerequisites

Connected with lectures of Physiology of cell systems and Genotoxicity and carcinogenesis

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

• General Biology (programme PřF, N-BI, specialization Ekotoxikologie)
• Special Biology (programme PřF, N-EXB)
• Special Biology (programme PřF, N-EXB, specialization Ekotoxikologie)

Course objectives

At the end of the course students should be able to: recognize the most harmful environmental factors and their impacts on human health including possibilities of disease prevention; describe specific dietary factors (especially of lipid character) and their association with etiology of some serious so-called civilization diseases, such as cardiovascular diseases, cancer, allergies or stress; understand the view of the organism as a hierarchical system and what are the basic processes necessary for maintenance of its homeostasis; interpret and use knowledge of environmental factors (especially dietary) influencing human health and of possibilities of disease prevention; explain recent results of epidemiologic and scientific studies of given topic; learn the ability to elaborate and present assigned topic.

Syllabus

• Causes of initiation and promotion of civilization diseases - genetic predisposition, life style. Type of studies (epidemiological, clinical, and experimental studies, population screening ), occurrence of cancer (in the Czech Republic, in the world).
• Carcinogenesis - main cancer promotion factors, genetic and non-genetic factors, endogenous factors - the role of hormones.
• Carcinogenesis and life style (smoking, diet, physical activities).
• Harmful environmental factors - radiation (ionizing, non-ionizing), chemicals and xenobiotics (heavy metals, aromatic hydrocarbons, PCBs, dioxins, pesticides, drugs etc.).
• Diet - energy balance, effects of high-glycide and high-fat diets, specific dietary lipids - butyrate, essential fatty acids.
• Chemoprevention - risk assessment, targets for decrease of risk and mortality, anticancer factors.
• Prevention, diagnostics and treatment of cancer.
• Experimental, epidemiologic and clinical studies, population screening, diagnostic markers.
• Therapy - surgery, radiation, chemotherapy, immunotherapy.
• Predictive oncology - detection of specific markers, comparison of methods and interpretation of measured parameters, data management and data interpretation - significance of multidimensional statistical analyses, predictive markers.
• Homeostasis, health and disease - basic terms, short introduction to the theory of systems.
• Negative and positive feedback - significance for homeostasis, homeostasis on the cell, tissue and system levels.
• Organism as hierarchic system, cooperation of nervous, endocrine and humoral systems.
• Causes of cardiovascular diseases.
• Causes of allergy and inflammation.
• Stress - causes and consequences.
• Prevention of functional damage and diseases vs. therapeutic possibilities.

Literature

recommended literature
• Food and Health in Europe: a new basis for action, WHO Regional Publications European Series, No. 96, 2006
• Wilhelm Z. a kol., Výživa v onkologii, (Nutrition in oncology) Brno 2004
• ZADÁK, Zdeněk. Výživa v intenzivní péči. 2. rozš. a aktualiz. vyd. Praha: Grada, 2009, 542 s. ISBN 9788024728445. info
• FOŘT, Petr. Co jíme a pijeme? Výživa pro 3. tisícitletí. (What we eat and drink? Nutrition for 3rd millenium) 1. vyd. Praha: Olympia, 2003. 246 s. ISBN 80-7033-814-8.
• Jak vzdorovat rakovině. (How to resist cancer) Edited by Olga Dostálová. [1. vyd.]. Praha: Grada-Avicenum, 1993. 205 s. ISBN 80-7169-040-6.
• Free radicals, aging, and degenerative diseases (Eds. J. E. Johnson, Jr., R. Walford, D. Harman, J. Miquel), Alan. R. Liss, Inc., New York 1986
• Speciální vybraná reviews a vědecké články (Thematic reviews and research papers)

Teaching methods

Basic lectures by teachers and associated discussion. Study of own selected research topic and its presentation with class discussion.

Assessment methods

Attendance of the lectures is not mandatory but recommended for understanding the topics, discussion with other students and creating and expression student's own opinion. Prerequisite for the course completion is preparation of about 10 min presentation for class colleagues and discussion of assigned topic. The final examination is based on written exam evaluated by the teacher. Students must answer minimally 6 from 10 questions covering the topics presented in the lectures.

Language of instruction

Czech

Follow-Up Courses

• Bi7070 Physiology of Cell Systems
• Bi8110 Mechanisms of carcinogenesis

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.
Information on course enrolment limitations: Na předmět se vztahuje povinnost registrace, bez registrace může být znemožněn zápis předmětu!

Bi6871 Health Risks

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: graded credit.

Teacher(s)

prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)
prof. RNDr. Alois Kozubík, CSc. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Jiřina Hofmanová, CSc.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science

Timetable

Tue 10:00–11:50 BFU

Prerequisites

Connected with lectures of Physiology of Cell Systems and Genotoxicity and Carcinogenesis

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

• General Biology (programme PřF, N-BI, specialization Ekotoxikologie)
• Special Biology (programme PřF, N-EXB)
• Special Biology (programme PřF, N-EXB, specialization Ekotoxikologie)

Course objectives

At the end of the course students should be able to: recognize the most harmful environmental factors and their impacts on human health including possibilities of disease prevention; describe specific dietary factors (especially of lipid character) and their association with etiology of some serious so-called civilization diseases, such as cardiovascular diseases, cancer, allergies or stress; understand the view of the organism as a hierarchical system and what are the basic processes necessary for maintenance of its homeostasis; interpret and use knowledge of environmental factors (especially dietary) influencing human health and of possibilities of disease prevention; explain recent results of epidemiologic and scientific studies of given topic; learn the ability to elaborate and present assigned topic.

Syllabus

• Causes of initiation and promotion of civilization diseases - genetic predisposition, life style. Type of studies (epidemiological, clinical, and experimental studies, population screning ), occurence of cancer (in the Czech Republic, in the world).
• Carcinogenesis - main cancer promotion factors, genetic and non-genetic factors, endogenous factors - the role of hormones.
• Carcinogenesis and life style (smoking, diet, physical activities).
• Harmful environmental factors - radiation (ionizing, non-ionizing), chemicals and xenobiotics (heavy metals, aromatic hydrocarbons, PCBs, dioxins, pesticides, drugs etc.).
• Diet - energy balance, effects of high-glycide nad high-fat diets, specific dietary lipids - butyrate, essential fatty acids.
• Chemoprevention - risk assesment, targets for decrease of risk and mortality , anticancer factors.
• Prevention, diagnostics and treatment of cancer.
• Experimental, epidemiologic and clinical studies, population screening, diagnostic markers.
• Therapy - surgery, radiation, chemotherapy, immunotherapy.
• Predictive oncology - detection of specific markers, comparison of methods and interpretation of measured parameters, data management and data interpretation - significance of multidimensional statistical analyses, predictive markers.
• Homeostasis, health and disease - basic terms, short introduction to the theory of systems.
• Negative and positive feedback - significance for homeostasis, homeostasis on the cell, tissue and system levels.
• Organism as hierarchic system, cooperation of nervous, endocrine and humoral systems.
• Causes of cardiovascular diseases.
• Causes of allergy and inflammation.
• Stress - causes and consequences.
• Prevention of functional damage and diseases vs. therapeutic possibilities.

Literature

recommended literature
• Food and Health in Europe: a new basis for action, WHO Regional Publications European Series, No. 96, 2006
• Wilhelm Z. a kol., Výživa v onkologii, (Nutrition in oncology) Brno 2004
• ZADÁK, Zdeněk. Výživa v intenzivní péči. 2. rozš. a aktualiz. vyd. Praha: Grada, 2009, 542 s. ISBN 9788024728445. info
• FOŘT, Petr. Co jíme a pijeme? Výživa pro 3. tisíciletí. (What we eat and drink? Nutrition for 3rd millenium)1. vyd. Praha: Olympia, 2003. 246 s. ISBN 80-7033-814-8.
• Jak vzdorovat rakovině. (How to resist cancer) Edited by Olga Dostálová. [1. vyd.]. Praha: Grada-Avicenum, 1993. 205 s. ISBN 80-7169-040-6.
• Free radicals, aging, and degenerative diseases (Eds. J. E. Johnson, Jr., R. Walford, D. Harman, J. Miquel), Alan. R. Liss, Inc., New York 1986
• Vybrané speciální reviews a vědecké články. Recommended thematic reviews and research papers

Teaching methods

Lectures, elaboration of specific topic and one's own presentation, class discussion.

Assessment methods

Presentation of assigned topic, final written test

Language of instruction

Czech

Follow-Up Courses

• Bi7070 Physiology of Cell Systems
• Bi8110 Mechanisms of carcinogenesis

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.
Information on course enrolment limitations: Na předmět se vztahuje povinnost registrace, bez registrace může být znemožněn zápis předmětu!

Bi6871 Health Risks

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: graded credit.

Teacher(s)

prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)
prof. RNDr. Alois Kozubík, CSc. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Jiřina Hofmanová, CSc.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science

Timetable

Tue 10:00–11:50 BFU

Prerequisites

Connected with lectures of Physiology of cell systems and Genotoxicity and carcinogenesis

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

• General Biology (programme PřF, M-BI, specialization Ekotoxikology)
• General Biology (programme PřF, M-BI, specialization Physiology of Animals)
• General Biology (programme PřF, N-BI, specialization Ekotoxikologie)
• Special Biology (programme PřF, N-EXB)
• Special Biology (programme PřF, N-EXB, specialization Ekotoxikologie)

Course objectives

At the end of the course students should be able to: recognize the most harmful environmental factors and their impacts on human health including possibilities of disease prevention; describe specific dietary factors (especially of lipid character) and their association with etiology of some serious so-called civilization diseases, such as cardiovascular diseases, cancer, allergies or stress; understand the view of the organism as a hierarchical system and what are the basic processes necessary for maintenance of its homeostasis; interpret and use knowledge of environmental factors (especially dietary) influencing human health and of possibilities of disease prevention; explain recent results of epidemiologic and scientific studies of given topic; learn the ability to elaborate and present assigned topic.

Syllabus

• Causes of initiation and promotion of civilization diseases - genetic predisposition, life style. Type of studies (epidemiological, clinical, and experimental studies, population screning ), occurence of cancer (in the Czech Republic, in the world).
• Carcinogenesis - main cancer promotion factors, genetic and non-genetic factors, endogenous factors - the role of hormones.
• Carcinogenesis and life style (smoking, diet, physical activities).
• Harmful environmental factors - radiation (ionizing, non-ionizing), chemicals and xenobiotics (heavy metals, aromatic hydrocarbons, PCBs, dioxins, pesticides, drugs etc.).
• Diet - energy balance, effects of high-glycide nad high-fat diets, specific dietary lipids - butyrate, essential fatty acids.
• Chemoprevention - risk assesment, targets for decrease of risk and mortality , anticancer factors.
• Prevention, diagnostics and treatment of cancer.
• Experimental, epidemiologic and clinical studies, population screening, diagnostic markers.
• Therapy - surgery, radiation, chemotherapy, immunotherapy.
• Predictive oncology - detection of specific markers, comparison of methods and interpretation of measured parameters, data management and data interpretation - significance of multidimensional statistical analyses, predictive markers.
• Homeostasis, health and disease - basic terms, short introduction to the theory of systems.
• Negative and positive feedback - significance for homeostasis, homeostasis on the cell, tissue and system levels.
• Organism as hierarchic system, cooperation of nervous, endocrine and humoral systems.
• Causes of cardiovascular diseases.
• Causes of allergy and inflammation.
• Stress - causes and consequences.
• Prevention of functional damage and diseases vs. therapeutic possibilities.

Literature

• Food and Health in Europe: a new basis for action, WHO Regional Publications European Series, No. 96, 2006
• Wilhelm Z. a kol., Výživa v onkologii, Brno 2004
• FOŘT, Petr. Co jíme a pijeme? : výživa pro 3. tisícitletí. 1. vyd. Praha: Olympia, 2003, 246 s. ISBN 8070338148. info
• Jak vzdorovat rakovině. Edited by Olga Dostálová. [1. vyd.]. Praha: Grada-Avicenum, 1993, 205 s. ISBN 80-7169-040-6. info
• Free radicals, aging, and degenerative diseases (Eds. J. E. Johnson, Jr., R. Walford, D. Harman, J. Miquel), Alan. R. Liss, Inc., New York 1986
• + speciální rewiev a separáty

Teaching methods

Lectures, elaboration of specific topic and one's own presentation, class discussion.

Assessment methods

Presentation of assigned topic, final written test

Language of instruction

Czech

Follow-Up Courses

• Bi7070 Physiology of Cell Systems
• Bi8110 Mechanisms of carcinogenesis

Further Comments

Study Materials
The course is taught annually.

Bi6871 Health Risks

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: graded credit.

Teacher(s)

prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)
prof. RNDr. Alois Kozubík, CSc. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Jiřina Hofmanová, CSc.

Timetable

Tue 10:00–11:50 BFU

Prerequisites

Connected with lectures of Physiology of cell systems and Genotoxicity and carcinogenesis

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

• General Biology (programme PřF, M-BI, specialization Ekotoxikology)
• General Biology (programme PřF, M-BI, specialization Physiology of Animals)
• General Biology (programme PřF, N-BI, specialization Ekotoxikologie)

Course objectives

At the end of the course students should be able to: recognize the most harmful environmental factors and their impacts on human health including possibilities of disease prevention; describe specific dietary factors (especially of lipid character) and their association with etiology of some serious so-called civilization diseases, such as cardiovascular diseases, cancer, allergies or stress; understand the view of the organism as a hierarchical system and what are the basic processes necessary for maintenance of its homeostasis; interpret and use knowledge of environmental factors (especially dietary) influencing human health and of possibilities of disease prevention; explain recent results of epidemiologic and scientific studies of given topic; learn the ability to elaborate and present assigned topic.

Syllabus

• Causes of initiation and promotion of civilization diseases - genetic predisposition, life style. Type of studies (epidemiological, clinical, and experimental studies, population screning ), occurence of cancer (in the Czech Republic, in the world).
• Carcinogenesis - main cancer promotion factors, genetic and non-genetic factors, endogenous factors - the role of hormones.
• Carcinogenesis and life style (smoking, diet, physical activities).
• Harmful environmental factors - radiation (ionizing, non-ionizing), chemicals and xenobiotics (heavy metals, aromatic hydrocarbons, PCBs, dioxins, pesticides, drugs etc.).
• Diet - energy balance, effects of high-glycide nad high-fat diets, specific dietary lipids - butyrate, essential fatty acids.
• Chemoprevention - risk assesment, targets for decrease of risk and mortality , anticancer factors.
• Prevention, diagnostics and treatment of cancer.
• Experimental, epidemiologic and clinical studies, population screening, diagnostic markers.
• Therapy - surgery, radiation, chemotherapy, immunotherapy.
• Predictive oncology - detection of specific markers, comparison of methods and interpretation of measured parameters, data management and data interpretation - significance of multidimensional statistical analyses, predictive markers.
• Homeostasis, health and disease - basic terms, short introduction to the theory of systems.
• Negative and positive feedback - significance for homeostasis, homeostasis on the cell, tissue and system levels.
• Organism as hierarchic system, cooperation of nervous, endocrine and humoral systems.
• Causes of cardiovascular diseases.
• Causes of allergy and inflammation.
• Stress - causes and consequences.
• Prevention of functional damage and diseases vs. therapeutic possibilities.

Literature

• Food and Health in Europe: a new basis for action, WHO Regional Publications European Series, No. 96, 2006
• Wilhelm Z. a kol., Výživa v onkologii, Brno 2004
• FOŘT, Petr. Co jíme a pijeme? : výživa pro 3. tisícitletí. 1. vyd. Praha: Olympia, 2003, 246 s. ISBN 8070338148. info
• Jak vzdorovat rakovině. Edited by Olga Dostálová. [1. vyd.]. Praha: Grada-Avicenum, 1993, 205 s. ISBN 80-7169-040-6. info
• Free radicals, aging, and degenerative diseases (Eds. J. E. Johnson, Jr., R. Walford, D. Harman, J. Miquel), Alan. R. Liss, Inc., New York 1986
• + speciální rewiev a separáty

Teaching methods

Lectures, elaboration of specific topic and one's own presentation, class discussion.

Assessment methods

Presentation of assigned topic, final written test

Language of instruction

Czech

Follow-Up Courses

• Bi7070 Physiology of Cell Systems
• Bi8110 Mechanisms of carcinogenesis

Further Comments

Study Materials
The course is taught annually.

Bi6871 Health Risks

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: graded credit.

Teacher(s)

prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)
prof. RNDr. Alois Kozubík, CSc. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Jiřina Hofmanová, CSc.

Timetable

Tue 13:00–14:50 BFU

Prerequisites

Connected with lectures of Physiology of cell systems and Genotoxicity and carcinogenesis

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

• General Biology (programme PřF, M-BI, specialization Ekotoxikology)
• General Biology (programme PřF, M-BI, specialization Physiology of Animals)
• General Biology (programme PřF, N-BI, specialization Ekotoxikologie)

Course objectives

At the end of the course students should be able to: recognize the most harmful environmental factors and their impacts on human health including possibilities of disease prevention; describe specific dietary factors (especially of lipid character) and their association with etiology of some serious so-called civilization diseases, such as cardiovascular diseases, cancer, allergies or stress; understand the view of the organism as a hierarchical system and what are the basic processes necessary for maintenance of its homeostasis; interpret and use knowledge of environmental factors (especially dietary) influencing human health and of possibilities of disease prevention; explain recent results of epidemiologic and scientific studies of given topic; learn the ability to elaborate and present assigned topic.

Syllabus

• Causes of initiation and promotion of civilization diseases - genetic predisposition, life style. Type of studies (epidemiological, clinical, and experimental studies, population screning ), occurence of cancer (in the Czech Republic, in the world).
• Carcinogenesis - main cancer promotion factors, genetic and non-genetic factors, endogenous factors - the role of hormones.
• Carcinogenesis and life style (smoking, diet, physical activities).
• Harmful environmental factors - radiation (ionizing, non-ionizing), chemicals and xenobiotics (heavy metals, aromatic hydrocarbons, PCBs, dioxins, pesticides, drugs etc.).
• Diet - energy balance, effects of high-glycide nad high-fat diets, specific dietary lipids - butyrate, essential fatty acids.
• Chemoprevention - risk assesment, targets for decrease of risk and mortality , anticancer factors.
• Prevention, diagnostics and treatment of cancer.
• Experimental, epidemiologic and clinical studies, population screening, diagnostic markers.
• Therapy - surgery, radiation, chemotherapy, immunotherapy.
• Predictive oncology - detection of specific markers, comparison of methods and interpretation of measured parameters, data management and data interpretation - significance of multidimensional statistical analyses, predictive markers.
• Homeostasis, health and disease - basic terms, short introduction to the theory of systems.
• Negative and positive feedback - significance for homeostasis, homeostasis on the cell, tissue and system levels.
• Organism as hierarchic system, cooperation of nervous, endocrine and humoral systems.
• Causes of cardiovascular diseases.
• Causes of allergy and inflammation.
• Stress - causes and consequences.
• Prevention of functional damage and diseases vs. therapeutic possibilities.

Literature

• Food and Health in Europe: a new basis for action, WHO Regional Publications European Series, No. 96, 2006
• Wilhelm Z. a kol., Výživa v onkologii, Brno 2004
• FOŘT, Petr. Co jíme a pijeme? : výživa pro 3. tisícitletí. 1. vyd. Praha: Olympia, 2003, 246 s. ISBN 8070338148. info
• Jak vzdorovat rakovině. Edited by Olga Dostálová. [1. vyd.]. Praha: Grada-Avicenum, 1993, 205 s. ISBN 80-7169-040-6. info
• Free radicals, aging, and degenerative diseases (Eds. J. E. Johnson, Jr., R. Walford, D. Harman, J. Miquel), Alan. R. Liss, Inc., New York 1986
• + speciální rewiev a separáty

Teaching methods

Lectures, elaboration of specific topic and one's own presentation, class discussion.

Assessment methods

Presentation of assigned topic, final written test

Language of instruction

Czech

Follow-Up Courses

• Bi7070 Physiology of Cell Systems
• Bi8110 Mechanisms of carcinogenesis

Further Comments

Study Materials
The course is taught annually.

Bi6871 Health Risks

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: graded credit.

Teacher(s)

prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)
prof. RNDr. Alois Kozubík, CSc. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Jiřina Hofmanová, CSc.

Timetable

Tue 15:00–16:50 BFU

Prerequisites

Connected with lectures of Physiology of cell systems and Genotoxicity and carcinogenesis

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

• General Biology (programme PřF, M-BI, specialization Ekotoxikology)
• General Biology (programme PřF, M-BI, specialization Physiology of Animals)
• General Biology (programme PřF, N-BI, specialization Ekotoxikologie)

Course objectives

The course gives an overview of the most harmful environmental factors and their impacts on human health including possibilities of disease prevention. Attention is aimed to specific dietary factors (especially of lipid character) and their association with etiology of some serious so-called civilisation diseases, such as cardiovascular diseases, cancer, allergies or stress. The organism is viewed as a hierarchical system and the basic processes that are necessary for maintaining of homeostasis are described.
Main objectives can be summarized as follows:
to gain basic knowledge of environmental factors (especially dietary)influencing human health and of possibilities of disease prevention; to aquaint with recent results of epidemiologic and scientific studies of given topic; to learn ability to elaborate and present assigned topic

Syllabus

• Causes of initiation and promotion of civilization diseases - genetic predisposition, life style. Type of studies (epidemiological, clinical, and experimental studies, population screning ), occurence of cancer (in the Czech Republic, in the world).
• Carcinogenesis - main cancer promotion factors, genetic and non-genetic factors, endogenous factors - the role of hormones.
• Carcinogenesis and life style (smoking, diet, physical activities).
• Harmful environmental factors - radiation (ionizing, non-ionizing), chemicals and xenobiotics (heavy metals, aromatic hydrocarbons, PCBs, dioxins, pesticides, drugs etc.).
• Diet - energy balance, effects of high-glycide nad high-fat diets, specific dietary lipids - butyrate, essential fatty acids.
• Chemoprevention - risk assesment, targets for decrease of risk and mortality , anticancer factors.
• Prevention, diagnostics and treatment of cancer.
• Experimental, epidemiologic and clinical studies, population screening, diagnostic markers.
• Therapy - surgery, radiation, chemotherapy, immunotherapy.
• Predictive oncology - detection of specific markers, comparison of methods and interpretation of measured parameters, data management and data interpretation - significance of multidimensional statistical analyses, predictive markers.
• Homeostasis, health and disease - basic terms, short introduction to the theory of systems.
• Negative and positive feedback - significance for homeostasis, homeostasis on the cell, tissue and system levels.
• Organism as hierarchic system, cooperation of nervous, endocrine and humoral systems.
• Causes of cardiovascular diseases.
• Causes of allergy and inflammation.
• Stress - causes and consequences.
• Prevention of functional damage and diseases vs. therapeutic possibilities.

Literature

• Food and Health in Europe: a new basis for action, WHO Regional Publications European Series, No. 96, 2006
• Wilhelm Z. a kol., Výživa v onkologii, Brno 2004
• FOŘT, Petr. Co jíme a pijeme? : výživa pro 3. tisícitletí. 1. vyd. Praha: Olympia, 2003, 246 s. ISBN 8070338148. info
• Jak vzdorovat rakovině. Edited by Olga Dostálová. [1. vyd.]. Praha: Grada-Avicenum, 1993, 205 s. ISBN 80-7169-040-6. info
• Free radicals, aging, and degenerative diseases (Eds. J. E. Johnson, Jr., R. Walford, D. Harman, J. Miquel), Alan. R. Liss, Inc., New York 1986
• + speciální rewiev a separáty

Assessment methods

Lectures, elaboration of specific topic and one's own presentation, class discussion. Presentation of assigned topic, final written test

Language of instruction

Czech

Follow-Up Courses

• C7530 Physiology of Cell Systems
• C8630 Genotoxicity and Carcinogenesis

Further Comments

Study Materials
The course is taught annually.

Bi6871 Health Risks

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: graded credit.

Teacher(s)

prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)
prof. RNDr. Alois Kozubík, CSc. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Jiřina Hofmanová, CSc.

Timetable

Tue 15:00–16:50 BFU

Prerequisites

Connected with lectures of Physiology of cell systems and Genotoxicity and carcinogenesis

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

• General Biology (programme PřF, M-BI, specialization Ekotoxikology)
• General Biology (programme PřF, M-BI, specialization Physiology of Animals)
• General Biology (programme PřF, N-BI, specialization Ekotoxikologie)

Course objectives

The course gives an overview of the most harmful environmental factors and their impacts on human health. It describes the background and etiology of some serious so-called civilisation diseases, such as cardiovascular diseases, cancer, allergies, impacts of stress, etc.. It also focuses on methods of prevention of these diseases. The organism is viewed as a hierarchical system and the basic processes that are necessary for maintaining of homeostasis are described.

Syllabus

• 1. Harmful environmental factors Lifestyle Diet 2. Homeostasis, health and disease Causes and impact of stress Radiation disease 3. Prevention and therapeutic possibilities 4. Causes of initiation and promotion of cancer Experimental, epidemiological and clinical studies, population screning 5. Diagnostic markers Prevention, diagnostics and therapy 6. Predictive oncology Detection of specific parameters Comparison of methods and interpretation of measured parameters Data managment and data interpretation

Literature

• STRATIL, Pavel. ABC zdravé výživy. 1. vyd. Brno: Pavel Stratil, 1993, S: iii-ix,. ISBN 80-900029-8-6. info
• Jak vzdorovat rakovině. Edited by Olga Dostálová. [1. vyd.]. Praha: Grada-Avicenum, 1993, 205 s. ISBN 80-7169-040-6. info
• J. Neuwirt, E. Nečas: Kmenové buňky a krevní choroby, Avicenum Praha 1981
• STREJČEK, Jiří and Jindřich LOKAJ. Imunologie v klinické praxi. 1. vyd. Praha: Avicenum, 1985, 293 s. info
• V. Wagner, M. Wagnerová: Ekoimunologie, Avicenum, Praha 1988
• T. L. Walden Jr., N. K. Farzaneh: Biochemistry of ionizing radiation, Raven Press, New York, 1990
• Free radicals, aging, and degenerative diseases (Eds. J. E. Johnson, Jr., R. Walford, D. Harman, J. Miquel), Alan. R. Liss, Inc., New York 1986
• + speciální rewiev a separáty

Language of instruction

Czech

Follow-Up Courses

• C7530 Physiology of Cell Systems
• C8630 Genotoxicity and Carcinogenesis

Further Comments

Study Materials
The course is taught annually.

Bi6871 Health Risks

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: graded credit.

Teacher(s)

prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)
prof. RNDr. Alois Kozubík, CSc. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Jiřina Hofmanová, CSc.

Timetable

Tue 15:00–16:50 BFU

Prerequisites

Connected with lectures of Physiology of cell systems and Genotoxicity and carcinogenesis

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

• General Biology (programme PřF, M-BI, specialization Ekotoxikology)
• General Biology (programme PřF, M-BI, specialization Physiology of Animals)
• General Biology (programme PřF, N-BI, specialization Ekotoxikologie)

Course objectives

The course gives an overview of the most harmful environmental factors and their impacts on human health. It describes the background and etiology of some serious so-called civilisation diseases, such as cardiovascular diseases, cancer, allergies, impacts of stress, etc.. It also focuses on methods of prevention of these diseases. The organism is viewed as a hierarchical system and the basic processes that are necessary for maintaining of homeostasis are described.

Syllabus

• 1. Harmful environmental factors Lifestyle Diet 2. Homeostasis, health and disease Causes and impact of stress Radiation disease 3. Prevention and therapeutic possibilities 4. Causes of initiation and promotion of cancer Experimental, epidemiological and clinical studies, population screning 5. Diagnostic markers Prevention, diagnostics and therapy 6. Predictive oncology Detection of specific parameters Comparison of methods and interpretation of measured parameters Data managment and data interpretation

Literature

• STRATIL, Pavel. ABC zdravé výživy. 1. vyd. Brno: Pavel Stratil, 1993, S: iii-ix,. ISBN 80-900029-8-6. info
• Jak vzdorovat rakovině. Edited by Olga Dostálová. [1. vyd.]. Praha: Grada-Avicenum, 1993, 205 s. ISBN 80-7169-040-6. info
• J. Neuwirt, E. Nečas: Kmenové buňky a krevní choroby, Avicenum Praha 1981
• STREJČEK, Jiří and Jindřich LOKAJ. Imunologie v klinické praxi. 1. vyd. Praha: Avicenum, 1985, 293 s. info
• V. Wagner, M. Wagnerová: Ekoimunologie, Avicenum, Praha 1988
• T. L. Walden Jr., N. K. Farzaneh: Biochemistry of ionizing radiation, Raven Press, New York, 1990
• Free radicals, aging, and degenerative diseases (Eds. J. E. Johnson, Jr., R. Walford, D. Harman, J. Miquel), Alan. R. Liss, Inc., New York 1986
• + speciální rewiev a separáty

Language of instruction

Czech

Follow-Up Courses

• C7530 Physiology of Cell Systems
• C8630 Genotoxicity and Carcinogenesis

Further Comments

Study Materials
The course is taught annually.

Bi6871 Health Risks

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Type of Completion: k (colloquium).

Teacher(s)

prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)
prof. RNDr. Alois Kozubík, CSc. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Ladislav Dušek, Ph.D.

Timetable

Tue 15:00–16:50 BFU

Prerequisites

Connected with lectures of Physiology of cell systems and Genotoxicity and carcinogenesis

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

• Ecotoxicology (programme PřF, M-BI)

Course objectives

The course gives an overview of the most harmful environmental factors and their impacts on human health. It describes the background and etiology of some serious so-called civilisation diseases, such as cardiovascular diseases, cancer, allergies, impacts of stress, etc.. It also focuses on methods of prevention of these diseases. The organism is viewed as a hierarchical system and the basic processes that are necessary for maintaining of homeostasis are described.

Syllabus

• 1. Harmful environmental factors Lifestyle Diet 2. Homeostasis, health and disease Causes and impact of stress Radiation disease 3. Prevention and therapeutic possibilities 4. Causes of initiation and promotion of cancer Experimental, epidemiological and clinical studies, population screning 5. Diagnostic markers Prevention, diagnostics and therapy 6. Predictive oncology Detection of specific parameters Comparison of methods and interpretation of measured parameters Data managment and data interpretation

Literature

• STRATIL, Pavel. ABC zdravé výživy. 1. vyd. Brno: Pavel Stratil, 1993, S: iii-ix,. ISBN 80-900029-8-6. info
• Jak vzdorovat rakovině. Edited by Olga Dostálová. [1. vyd.]. Praha: Grada-Avicenum, 1993, 205 s. ISBN 80-7169-040-6. info
• J. Neuwirt, E. Nečas: Kmenové buňky a krevní choroby, Avicenum Praha 1981
• STREJČEK, Jiří and Jindřich LOKAJ. Imunologie v klinické praxi. 1. vyd. Praha: Avicenum, 1985, 293 s. info
• V. Wagner, M. Wagnerová: Ekoimunologie, Avicenum, Praha 1988
• T. L. Walden Jr., N. K. Farzaneh: Biochemistry of ionizing radiation, Raven Press, New York, 1990
• Free radicals, aging, and degenerative diseases (Eds. J. E. Johnson, Jr., R. Walford, D. Harman, J. Miquel), Alan. R. Liss, Inc., New York 1986
• + speciální rewiev a separáty

Language of instruction

Czech

Follow-Up Courses

• C7530 Physiology of Cell Systems
• C8630 Genotoxicity and Carcinogenesis

Further Comments

Study Materials
The course is taught annually.

Bi6871 Health Risks

Extent and Intensity

2/0/0. 2 credit(s). Type of Completion: k (colloquium).

Teacher(s)

prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)
prof. RNDr. Alois Kozubík, CSc. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
RECETOX – Faculty of Science
Contact Person: prof. RNDr. Ladislav Dušek, Ph.D.

Timetable

Tue 15:00–16:50 BFU

Prerequisites

Connected with lectures of Physiology of cell systems and Genotoxicity and carcinogenesis

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

• Ecotoxicology (programme PřF, M-BI)

Course objectives

The course gives an overview of the most harmful environmental factors and their impacts on human health. It describes the background and etiology of some serious so-called civilisation diseases, such as cardiovascular diseases, cancer, allergies, impacts of stress, etc.. It also focuses on methods of prevention of these diseases. The organism is viewed as a hierarchical system and the basic processes that are necessary for maintaining of homeostasis are described.

Syllabus

• 1. Harmful environmental factors Lifestyle Diet 2. Homeostasis, health and disease Causes and impact of stress Radiation disease 3. Prevention and therapeutic possibilities 4. Causes of initiation and promotion of cancer Experimental, epidemiological and clinical studies, population screning 5. Diagnostic markers Prevention, diagnostics and therapy 6. Predictive oncology Detection of specific parameters Comparison of methods and interpretation of measured parameters Data managment and data interpretation

Literature

• STRATIL, Pavel. ABC zdravé výživy. 1. vyd. Brno: Pavel Stratil, 1993, S: iii-ix,. ISBN 80-900029-8-6. info
• Jak vzdorovat rakovině. Edited by Olga Dostálová. [1. vyd.]. Praha: Grada-Avicenum, 1993, 205 s. ISBN 80-7169-040-6. info
• J. Neuwirt, E. Nečas: Kmenové buňky a krevní choroby, Avicenum Praha 1981
• STREJČEK, Jiří and Jindřich LOKAJ. Imunologie v klinické praxi. 1. vyd. Praha: Avicenum, 1985, 293 s. info
• V. Wagner, M. Wagnerová: Ekoimunologie, Avicenum, Praha 1988
• T. L. Walden Jr., N. K. Farzaneh: Biochemistry of ionizing radiation, Raven Press, New York, 1990
• Free radicals, aging, and degenerative diseases (Eds. J. E. Johnson, Jr., R. Walford, D. Harman, J. Miquel), Alan. R. Liss, Inc., New York 1986
• + speciální rewiev a separáty

Language of instruction

Czech

Follow-Up Courses

• C7530 Physiology of Cell Systems
• C8630 Genotoxicity and Carcinogenesis

Further Comments

The course is taught annually.

Bi6871 Health Risks

Extent and Intensity

2/0/0. 2 credit(s). Type of Completion: k (colloquium).

Teacher(s)

prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)
prof. RNDr. Alois Kozubík, CSc. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
RECETOX – Faculty of Science
Contact Person: prof. RNDr. Ladislav Dušek, Ph.D.

Timetable

Tue 15:00–16:50 BFU

Prerequisites

Connected with lectures of Physiology of cell systems and Genotoxicity and carcinogenesis

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

• Ecotoxicology (programme PřF, M-BI)

Course objectives

The course gives an overview of the most harmful environmental factors and their impacts on human health. It describes the background and etiology of some serious so-called civilisation diseases, such as cardiovascular diseases, cancer, allergies, impacts of stress, etc.. It also focuses on methods of prevention of these diseases. The organism is viewed as a hierarchical system and the basic processes that are necessary for maintaining of homeostasis are described.

Syllabus

• 1. Harmful environmental factors Lifestyle Diet 2. Homeostasis, health and disease Causes and impact of stress Radiation disease 3. Prevention and therapeutic possibilities 4. Causes of initiation and promotion of cancer Experimental, epidemiological and clinical studies, population screning 5. Diagnostic markers Prevention, diagnostics and therapy 6. Predictive oncology Detection of specific parameters Comparison of methods and interpretation of measured parameters Data managment and data interpretation

Literature

• STRATIL, Pavel. ABC zdravé výživy. 1. vyd. Brno: Pavel Stratil, 1993, S: iii-ix,. ISBN 80-900029-8-6. info
• Jak vzdorovat rakovině. Edited by Olga Dostálová. [1. vyd.]. Praha: Grada-Avicenum, 1993, 205 s. ISBN 80-7169-040-6. info
• J. Neuwirt, E. Nečas: Kmenové buňky a krevní choroby, Avicenum Praha 1981
• STREJČEK, Jiří and Jindřich LOKAJ. Imunologie v klinické praxi. 1. vyd. Praha: Avicenum, 1985, 293 s. info
• V. Wagner, M. Wagnerová: Ekoimunologie, Avicenum, Praha 1988
• T. L. Walden Jr., N. K. Farzaneh: Biochemistry of ionizing radiation, Raven Press, New York, 1990
• Free radicals, aging, and degenerative diseases (Eds. J. E. Johnson, Jr., R. Walford, D. Harman, J. Miquel), Alan. R. Liss, Inc., New York 1986
• + speciální rewiev a separáty

Language of instruction

Czech

Follow-Up Courses

• C7530 Physiology of Cell Systems
• C8630 Genotoxicity and Carcinogenesis

Further Comments

The course is taught annually.

Bi6871 Health Risks

Extent and Intensity

2/0/0. 2 credit(s). Type of Completion: k (colloquium).

Teacher(s)

prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)
prof. RNDr. Alois Kozubík, CSc. (lecturer)
prof. RNDr. Jakub Hofman, Ph.D. (assistant)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
RECETOX – Faculty of Science
Contact Person: prof. RNDr. Ladislav Dušek, Ph.D.

Prerequisites

Connected with lectures of Physiology of cell systems and Genotoxicity and carcinogenesis

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

• Ecotoxicology (programme PřF, M-BI)

Course objectives

The course gives an overview of the most harmful environmental factors and their impacts on human health. It describes the background and etiology of some serious so-called civilisation diseases, such as cardiovascular diseases, cancer, allergies, impacts of stress, etc.. It also focuses on methods of prevention of these diseases. The organism is viewed as a hierarchical system and the basic processes that are necessary for maintaining of homeostasis are described.

Syllabus

• 1. Harmful environmental factors Lifestyle Diet 2. Homeostasis, health and disease Causes and impact of stress Radiation disease 3. Prevention and therapeutic possibilities 4. Causes of initiation and promotion of cancer Experimental, epidemiological and clinical studies, population screning 5. Diagnostic markers Prevention, diagnostics and therapy 6. Predictive oncology Detection of specific parameters Comparison of methods and interpretation of measured parameters Data managment and data interpretation

Literature

• STRATIL, Pavel. ABC zdravé výživy. 1. vyd. Brno: Pavel Stratil, 1993, S: iii-ix,. ISBN 80-900029-8-6. info
• Jak vzdorovat rakovině. Edited by Olga Dostálová. [1. vyd.]. Praha: Grada-Avicenum, 1993, 205 s. ISBN 80-7169-040-6. info
• J. Neuwirt, E. Nečas: Kmenové buňky a krevní choroby, Avicenum Praha 1981
• STREJČEK, Jiří and Jindřich LOKAJ. Imunologie v klinické praxi. 1. vyd. Praha: Avicenum, 1985, 293 s. info
• V. Wagner, M. Wagnerová: Ekoimunologie, Avicenum, Praha 1988
• T. L. Walden Jr., N. K. Farzaneh: Biochemistry of ionizing radiation, Raven Press, New York, 1990
• Free radicals, aging, and degenerative diseases (Eds. J. E. Johnson, Jr., R. Walford, D. Harman, J. Miquel), Alan. R. Liss, Inc., New York 1986
• + speciální rewiev a separáty

Language of instruction

Czech

Follow-Up Courses

• C7530 Physiology of Cell Systems
• C8630 Genotoxicity and Carcinogenesis

Further Comments

The course is taught annually.
The course is taught: every week.

Bi6871 Health Risks

The course is not taught in Spring 2017

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: graded credit.

Teacher(s)

prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)
prof. RNDr. Alois Kozubík, CSc. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Jiřina Hofmanová, CSc.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science

Prerequisites

SOUHLAS
Basic knowledge of cell biology, physiology, biochemistry and molecular biology are recommended. Connected with lectures of Physiology of cell systems and Genotoxicity and carcinogenesis

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

• General Biology (programme PřF, N-BI, specialization Ekotoxikologie)
• Special Biology (programme PřF, N-EXB)
• Special Biology (programme PřF, N-EXB, specialization Ekotoxikologie)

Course objectives

The course acquaints students with knowledge of the causes of selected disorders and disease development, particularly lifestyle diseases such as such as cardiovascular diseases, cancer, allergies, stress, and psychiatric disorders, including approaches and methods of their study. This means namely influence of environmental factors on human health with emphasis on the role of life style and specific dietary components and the practical use of knowledge in disease prevention. Students also obtain information about regulation of organism as hierarchical systém, about basic processes neccessary for maintainance of normal functions and about factors disturbing them.

Learning outcomes

At the end of the course students should be able to: recognize the most harmful environmental factors and their impacts on human health including possibilities of disease prevention; understand the role of specific dietary factors (especially of lipid character) and their association with etiology of some serious, so-called civilization diseases; explain the view of the organism as a hierarchical system and the basic processes necessary for maintenance of its homeostasis; interpret and use knowledge of environmental factors influencing human health and of possibilities of disease prevention and therapy; understand recent results of epidemiologic and scientific studies of given topic; learn the ability to elaborate, present, and discuss assigned topic.

Syllabus

• Causes of initiation and promotion of civilization diseases - genetic predisposition, life style. Type of studies (epidemiological, clinical, and experimental studies, population screening ), occurrence of cancer (in the Czech Republic, in the world).
• Carcinogenesis - main cancer promotion factors, genetic and non-genetic factors, endogenous factors - the role of hormones.
• Carcinogenesis and life style (smoking, diet, physical activities).
• Harmful environmental factors - radiation (ionizing, non-ionizing), chemicals and xenobiotics (heavy metals, aromatic hydrocarbons, PCBs, dioxins, pesticides, drugs etc.).
• Diet - energy balance, effects of high-glycide and high-fat diets, specific dietary lipids - butyrate, essential fatty acids.
• Chemoprevention - risk assessment, targets for decrease of risk and mortality, anticancer factors.
• Prevention, diagnostics and treatment of cancer.
• Experimental, epidemiologic and clinical studies, population screening, diagnostic markers.
• Therapy - surgery, radiation, chemotherapy, immunotherapy.
• Predictive oncology - detection of specific markers, comparison of methods and interpretation of measured parameters, data management and data interpretation - significance of multidimensional statistical analyses, predictive markers.
• Homeostasis, health and disease - basic terms, short introduction to the theory of systems.
• Negative and positive feedback - significance for homeostasis, homeostasis on the cell, tissue and system levels.
• Organism as hierarchic system, cooperation of nervous, endocrine and humoral systems.
• Causes of cardiovascular diseases.
• Causes of allergy and inflammation.
• Stress - causes and consequences.
• Prevention of functional damage and diseases vs. therapeutic possibilities.

Literature

recommended literature
• Food and Health in Europe: a new basis for action, WHO Regional Publications European Series, No. 96, 2006
• Wilhelm Z. a kol., Výživa v onkologii, (Nutrition in oncology) Brno 2004
• ZADÁK, Zdeněk. Výživa v intenzivní péči. 2. rozš. a aktualiz. vyd. Praha: Grada, 2009, 542 s. ISBN 9788024728445. info
• FOŘT, Petr. Co jíme a pijeme? Výživa pro 3. tisícitletí. (What we eat and drink? Nutrition for 3rd millenium) 1. vyd. Praha: Olympia, 2003. 246 s. ISBN 80-7033-814-8.
• Jak vzdorovat rakovině. (How to resist cancer) Edited by Olga Dostálová. [1. vyd.]. Praha: Grada-Avicenum, 1993. 205 s. ISBN 80-7169-040-6.
• Free radicals, aging, and degenerative diseases (Eds. J. E. Johnson, Jr., R. Walford, D. Harman, J. Miquel), Alan. R. Liss, Inc., New York 1986
• Speciální vybraná reviews a vědecké články (Thematic reviews and research papers)

Teaching methods

Basic lectures by teachers and associated discussion. Study of own selected research topic and its presentation with class discussion.

Assessment methods

Attendance of the lectures is not mandatory but recommended for understanding the topics, discussion with other students and creating and expression student's own opinion. Prerequisite for the course completion is preparation of about 10 min presentation for class colleagues and discussion of assigned topic. The final examination is based on written exam evaluated by the teacher. Students must answer minimally 6 from 10 questions covering the topics presented in the lectures.

Language of instruction

Czech

Follow-Up Courses

• Bi7070 Physiology of Cell Systems
• Bi8110 Mechanisms of carcinogenesis

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.
The course is taught: every week.
Information on course enrolment limitations: POZOR: Ze zdravotních důvodů nebude tento předmět vyučován v semestru jaro 2017! Výjimečně bude přesunut do semestru podzim 2017.

Na předmět se vztahuje povinnost registrace.

Bi6871 Health Risks

The information about the term spring 2012 - acreditation is not made public

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: graded credit.

Teacher(s)

prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)
prof. RNDr. Alois Kozubík, CSc. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Jiřina Hofmanová, CSc.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science

Prerequisites

Connected with lectures of Physiology of cell systems and Genotoxicity and carcinogenesis

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

• General Biology (programme PřF, M-BI, specialization Ekotoxikology)
• General Biology (programme PřF, M-BI, specialization Physiology of Animals)
• General Biology (programme PřF, N-BI, specialization Ekotoxikologie)

Course objectives

At the end of the course students should be able to: recognize the most harmful environmental factors and their impacts on human health including possibilities of disease prevention; describe specific dietary factors (especially of lipid character) and their association with etiology of some serious so-called civilization diseases, such as cardiovascular diseases, cancer, allergies or stress; understand the view of the organism as a hierarchical system and what are the basic processes necessary for maintenance of its homeostasis; interpret and use knowledge of environmental factors (especially dietary) influencing human health and of possibilities of disease prevention; explain recent results of epidemiologic and scientific studies of given topic; learn the ability to elaborate and present assigned topic.

Syllabus

• Causes of initiation and promotion of civilization diseases - genetic predisposition, life style. Type of studies (epidemiological, clinical, and experimental studies, population screning ), occurence of cancer (in the Czech Republic, in the world).
• Carcinogenesis - main cancer promotion factors, genetic and non-genetic factors, endogenous factors - the role of hormones.
• Carcinogenesis and life style (smoking, diet, physical activities).
• Harmful environmental factors - radiation (ionizing, non-ionizing), chemicals and xenobiotics (heavy metals, aromatic hydrocarbons, PCBs, dioxins, pesticides, drugs etc.).
• Diet - energy balance, effects of high-glycide nad high-fat diets, specific dietary lipids - butyrate, essential fatty acids.
• Chemoprevention - risk assesment, targets for decrease of risk and mortality , anticancer factors.
• Prevention, diagnostics and treatment of cancer.
• Experimental, epidemiologic and clinical studies, population screening, diagnostic markers.
• Therapy - surgery, radiation, chemotherapy, immunotherapy.
• Predictive oncology - detection of specific markers, comparison of methods and interpretation of measured parameters, data management and data interpretation - significance of multidimensional statistical analyses, predictive markers.
• Homeostasis, health and disease - basic terms, short introduction to the theory of systems.
• Negative and positive feedback - significance for homeostasis, homeostasis on the cell, tissue and system levels.
• Organism as hierarchic system, cooperation of nervous, endocrine and humoral systems.
• Causes of cardiovascular diseases.
• Causes of allergy and inflammation.
• Stress - causes and consequences.
• Prevention of functional damage and diseases vs. therapeutic possibilities.

Literature

• Food and Health in Europe: a new basis for action, WHO Regional Publications European Series, No. 96, 2006
• Wilhelm Z. a kol., Výživa v onkologii, Brno 2004
• FOŘT, Petr. Co jíme a pijeme? : výživa pro 3. tisícitletí. 1. vyd. Praha: Olympia, 2003, 246 s. ISBN 8070338148. info
• Jak vzdorovat rakovině. Edited by Olga Dostálová. [1. vyd.]. Praha: Grada-Avicenum, 1993, 205 s. ISBN 80-7169-040-6. info
• Free radicals, aging, and degenerative diseases (Eds. J. E. Johnson, Jr., R. Walford, D. Harman, J. Miquel), Alan. R. Liss, Inc., New York 1986
• + speciální rewiev a separáty

Teaching methods

Lectures, elaboration of specific topic and one's own presentation, class discussion.

Assessment methods

Presentation of assigned topic, final written test

Language of instruction

Czech

Follow-Up Courses

• Bi7070 Physiology of Cell Systems
• Bi8110 Mechanisms of carcinogenesis

Further Comments

The course is taught annually.
The course is taught: every week.

Bi6871 Health Risks

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: graded credit.

Teacher(s)

prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)
prof. RNDr. Alois Kozubík, CSc. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Jiřina Hofmanová, CSc.

Prerequisites

Connected with lectures of Physiology of cell systems and Genotoxicity and carcinogenesis

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

• General Biology (programme PřF, M-BI, specialization Ekotoxikology)
• General Biology (programme PřF, M-BI, specialization Physiology of Animals)
• General Biology (programme PřF, N-BI, specialization Ekotoxikologie)

Course objectives

At the end of the course students should be able to: recognize the most harmful environmental factors and their impacts on human health including possibilities of disease prevention; describe specific dietary factors (especially of lipid character) and their association with etiology of some serious so-called civilization diseases, such as cardiovascular diseases, cancer, allergies or stress; understand the view of the organism as a hierarchical system and what are the basic processes necessary for maintenance of its homeostasis; interpret and use knowledge of environmental factors (especially dietary) influencing human health and of possibilities of disease prevention; explain recent results of epidemiologic and scientific studies of given topic; learn the ability to elaborate and present assigned topic.

Syllabus

• Causes of initiation and promotion of civilization diseases - genetic predisposition, life style. Type of studies (epidemiological, clinical, and experimental studies, population screning ), occurence of cancer (in the Czech Republic, in the world).
• Carcinogenesis - main cancer promotion factors, genetic and non-genetic factors, endogenous factors - the role of hormones.
• Carcinogenesis and life style (smoking, diet, physical activities).
• Harmful environmental factors - radiation (ionizing, non-ionizing), chemicals and xenobiotics (heavy metals, aromatic hydrocarbons, PCBs, dioxins, pesticides, drugs etc.).
• Diet - energy balance, effects of high-glycide nad high-fat diets, specific dietary lipids - butyrate, essential fatty acids.
• Chemoprevention - risk assesment, targets for decrease of risk and mortality , anticancer factors.
• Prevention, diagnostics and treatment of cancer.
• Experimental, epidemiologic and clinical studies, population screening, diagnostic markers.
• Therapy - surgery, radiation, chemotherapy, immunotherapy.
• Predictive oncology - detection of specific markers, comparison of methods and interpretation of measured parameters, data management and data interpretation - significance of multidimensional statistical analyses, predictive markers.
• Homeostasis, health and disease - basic terms, short introduction to the theory of systems.
• Negative and positive feedback - significance for homeostasis, homeostasis on the cell, tissue and system levels.
• Organism as hierarchic system, cooperation of nervous, endocrine and humoral systems.
• Causes of cardiovascular diseases.
• Causes of allergy and inflammation.
• Stress - causes and consequences.
• Prevention of functional damage and diseases vs. therapeutic possibilities.

Literature

• Food and Health in Europe: a new basis for action, WHO Regional Publications European Series, No. 96, 2006
• Wilhelm Z. a kol., Výživa v onkologii, Brno 2004
• FOŘT, Petr. Co jíme a pijeme? : výživa pro 3. tisícitletí. 1. vyd. Praha: Olympia, 2003, 246 s. ISBN 8070338148. info
• Jak vzdorovat rakovině. Edited by Olga Dostálová. [1. vyd.]. Praha: Grada-Avicenum, 1993, 205 s. ISBN 80-7169-040-6. info
• Free radicals, aging, and degenerative diseases (Eds. J. E. Johnson, Jr., R. Walford, D. Harman, J. Miquel), Alan. R. Liss, Inc., New York 1986
• + speciální rewiev a separáty

Teaching methods

Lectures, elaboration of specific topic and one's own presentation, class discussion.

Assessment methods

Presentation of assigned topic, final written test

Language of instruction

Czech

Follow-Up Courses

• Bi7070 Physiology of Cell Systems
• Bi8110 Mechanisms of carcinogenesis

Further Comments

The course is taught annually.
The course is taught: every week.

Bi6871 Health Risks

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: graded credit.

Teacher(s)

prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)
prof. RNDr. Alois Kozubík, CSc. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Jiřina Hofmanová, CSc.

Prerequisites

Connected with lectures of Physiology of cell systems and Genotoxicity and carcinogenesis

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

• General Biology (programme PřF, M-BI, specialization Ekotoxikology)
• General Biology (programme PřF, M-BI, specialization Physiology of Animals)
• General Biology (programme PřF, N-BI, specialization Ekotoxikologie)

Course objectives

The course gives an overview of the most harmful environmental factors and their impacts on human health. It describes the background and etiology of some serious so-called civilisation diseases, such as cardiovascular diseases, cancer, allergies, impacts of stress, etc.. It also focuses on methods of prevention of these diseases. The organism is viewed as a hierarchical system and the basic processes that are necessary for maintaining of homeostasis are described.

Syllabus

• 1. Harmful environmental factors Lifestyle Diet 2. Homeostasis, health and disease Causes and impact of stress Radiation disease 3. Prevention and therapeutic possibilities 4. Causes of initiation and promotion of cancer Experimental, epidemiological and clinical studies, population screning 5. Diagnostic markers Prevention, diagnostics and therapy 6. Predictive oncology Detection of specific parameters Comparison of methods and interpretation of measured parameters Data managment and data interpretation

Literature

• STRATIL, Pavel. ABC zdravé výživy. 1. vyd. Brno: Pavel Stratil, 1993, S: iii-ix,. ISBN 80-900029-8-6. info
• Jak vzdorovat rakovině. Edited by Olga Dostálová. [1. vyd.]. Praha: Grada-Avicenum, 1993, 205 s. ISBN 80-7169-040-6. info
• J. Neuwirt, E. Nečas: Kmenové buňky a krevní choroby, Avicenum Praha 1981
• STREJČEK, Jiří and Jindřich LOKAJ. Imunologie v klinické praxi. 1. vyd. Praha: Avicenum, 1985, 293 s. info
• V. Wagner, M. Wagnerová: Ekoimunologie, Avicenum, Praha 1988
• T. L. Walden Jr., N. K. Farzaneh: Biochemistry of ionizing radiation, Raven Press, New York, 1990
• Free radicals, aging, and degenerative diseases (Eds. J. E. Johnson, Jr., R. Walford, D. Harman, J. Miquel), Alan. R. Liss, Inc., New York 1986
• + speciální rewiev a separáty

Language of instruction

Czech

Follow-Up Courses

• C7530 Physiology of Cell Systems
• C8630 Genotoxicity and Carcinogenesis

Further Comments

The course is taught annually.
The course is taught: every week.

• Enrolment Statistics (Spring 2025, recent)