C8580 Risk Analysis

Faculty of Science
Spring 2019
Extent and Intensity
2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).
doc. RNDr. Pavel Čupr, Ph.D. (lecturer)
Guaranteed by
prof. RNDr. Jana Klánová, Ph.D.
RECETOX - Faculty of Science
Contact Person: doc. RNDr. Pavel Čupr, Ph.D.
Supplier department: RECETOX - Faculty of Science
Mon 18. 2. to Fri 17. 5. Fri 9:00–10:50 D29/347-RCX2
Doporučené: C4300 Environmental Chemistry I C4310 Environmental Chemistry II C4320 Environmental Chemistry III (I)II-IV, Toxicology and General ecotoxicology
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
- define human and environmental risk assessment methods
- apply basic methods of human and ecological risk assessment
- explain how different exposure parameters can influence final risk predictions
- define main exposure routes (oral, inhalational, dermal, dietary exposure, ...)
- characterize and quantify significant potential risks
- recognize main exposure factors, which have significant effect in total risk assessment
- interpret acceptable carcinogenic and non-carcinogenic risk level
- solve practical case study with risk quantification from define exposure scenarios.
  • Introduction - basic concept definition: hazard, risk, risk assessment and risk management.
  • Reasons of risk assessment application: local, regional and global effects, risk perception.
  • Main risk assessment component: hazard identification, dose - response relationships, exposure analysis, risk characterization, risk management.
  • Methods of HUMAN RISK quantification: pharmacokinetic models, carcinogenic a non-carcinogenic risk assessment methods – detail procedure, software applications (PC lecture room - RECETOX)
  • Ecological and environmental risk assessment
  • PBPK modeling (toxicokinetic models; applications).
  • New projects with Human health risk assessment approaches. New Data-sources.
  • Biomonitoring and application in human health risk assessment (human milk, ..).
  • Case study (every students will have original study subject).
    recommended literature
  • FJELD, Robert A., Norman A. EISENBERG and Keith L. COMPTON. Quantitative environmental risk analysis for human health. Hoboken, N.J.: Wiley-Interscience, 2007. xiii, 390. ISBN 9780471722434. info
    not specified
  • Ecological risk assessment. Edited by Glenn W. Suter. 2nd ed. Boca Raton: CRC Press/Taylor & Francis, 2007. 643 p. ISBN 9781566706346. info
  • Risk assessment of chemicals : an introduction. Edited by C. J. van Leeuwen - T. G. Vermeire. 2nd ed. Dordrecht: Springer, 2007. xxxii, 686. ISBN 9789048175369. info
  • Diseases maping and risk assessment for public health. Edited by Andrew Lawson. 1st ed. Chichester: John Wiley & Sons, 2002. xix, 482. ISBN 0471986348. info
  • KAISER, Jamil. Bioindicators and biomarkers of environmental pollution and risk assessment. Enfield, N.H.: Science Publishers, 2001. xviii, 204. ISBN 1578081629. info
  • Uncertainty analysis in ecological risk assessment. Edited by William Warren-Hicks - Dwayne R. J. Moore. Pensacola, Fla.: SETAC Press, 1998. xxxiii, 27. ISBN 1880611244. info
  • Challenges in risk assessment and risk management. Edited by Howard Kunreuther - Paul Slovic. Thousand Oaks: SAGE Periodical Press, 1996. 220 s. info
  • Fundamentals of aquatic toxicology : effects, environmental fate, and risk assessment. Edited by Gary M. Rand. 2nd ed. Boca Raton: CRC Press, 1995. xxi, 1125. ISBN 1560320915. info
  • Risk assessment of essential elements. Edited by Walter Mertz. [1st ed.]. Washington: ILSI Press, 1994. xxviii, 30. ISBN 0-944398-21-9. info
Teaching methods
Education is performed as lectures with Powerpoint prezentation. Understanding of mechanisms and consequences is emphasized. Students are frequently asked questions to think about actual topic. They are encouraged to ask questions and be in interaction with the lecturer.
Assessment methods
Attendance of the lectures is not mandatory but very strongly recommended for fluent understanding of the educated subjects. During the lectures, students are asked about subjects of past lecture. Final assesment (at the end of semester) is by written examination. It is 22 questions, which frequently require description, explanation or schematization of asked topic. Questions have max 2 points according to their difficulty. Total count is 44 and to pass at least 35 points are needed. Students must realize practical case study with risk quantification from define exposure scenarios (Individual Case Study).
Language of instruction
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
The course is also listed under the following terms Spring 2008 - for the purpose of the accreditation, Spring 2011 - only for the accreditation, Spring 2000, Spring 2001, Spring 2002, Spring 2003, Spring 2004, Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, spring 2012 - acreditation, Spring 2013, Autumn 2013, Spring 2014, Autumn 2014, Spring 2015, Spring 2016, Spring 2017, spring 2018.
  • Enrolment Statistics (recent)
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