PřF:F9603 From diagn. to pharmeceutics - Course Information
F9603 From diagnosis towards pharmaceuticsFaculty of Science
- Extent and Intensity
- 2/1. 3 credit(s) (plus extra credits for completion). Type of Completion: z (credit).
- doc. Mgr. Karel Kubíček, PhD. (lecturer)
doc. Mgr. Olga Nováková, Dr. (lecturer)
- Guaranteed by
- prof. RNDr. Josef Humlíček, CSc.
Department of Condensed Matter Physics - Physics Section - Faculty of Science
Supplier department: Department of Condensed Matter Physics - Physics Section - Faculty of Science
- Mon 17:00–18:50 F2,02012
- Timetable of Seminar Groups:
- Basic knowledge of human body, nucleic acids, proteins, organic chemistry and basic label knowledge of theoretical and experimental methods applied for studies of interactions between biomolecules
- Course Enrolment Limitations
- The course is also offered to the students of the fields other than those the course is directly associated with.
- fields of study / plans the course is directly associated with
- Course objectives
- The goal of the course is to provide the students logical connections between the macro-/micro-scopic aspects of several common diseases of humans (Alzheimer, Bekhterev, cancer) and changes in protein primary to tertiary structure, which affect the protein-protein interaction, (un)folding of the protein, protein-nucleic acid interaction, protein-ligand interaction. The course will also show the strategies for designing cures and therapy of these diseases.
- 1) The concept of identification and characterization of a disease 2) Historical evolution of therapy 3) Identification of a disease at a molecular level 4) The role of (un)folding, changes in primary sequence 5) Protein-protein, protein-NA, protein-ligand interactions 6) Drug-design
- recommended literature
- Fillit, H.M. & O'Connell, A.W.: DRUG DISCOVERY AND DEVELOPMENT FOR ALZHEIMER'S DISEASE 2000, Springer, 2002
- Factor, S.A. & Weiner, W.J.: Parkinson’s Disease Diagnosis and Clinical Management 2nd Ed, Demos, NY, 2008
- Hobbie, R.K. & Roth, B.J.: Intermediate Physics for Medicine and Biology 4th Ed, Springer, 2007
- Jucker, M., Beyreuther, K., Haass, C., Nitsch, R.M., Christen, Y.:)Alzheimer:100 Years and Beyond, Springer, 2006
- Teaching methods
- lectures, class discussion
- Assessment methods
- Final oral exam – dissection of scientific publication
- Language of instruction
- Further Comments
- Study Materials
The course is taught annually.