FATO1_14 Toxicology

Farmaceutická fakulta
podzim 2021
2/1/0. 4 kr. Doporučované ukončení: zk. Jiná možná ukončení: z.
Vyučováno prezenčně.
MUDr. Marta Chalupová, Ph.D. (přednášející)
doc. PharmDr. Peter Kollár, Ph.D. (přednášející)
MUDr. Tomáš Parák, Ph.D. (přednášející)
prof. PharmDr. Karel Šmejkal, Ph.D. (přednášející)
MUDr. Marta Chalupová, Ph.D. (cvičící)
PharmDr. Tereza Kauerová, Ph.D. (cvičící)
doc. PharmDr. Peter Kollár, Ph.D. (cvičící)
PharmDr. Mgr. Alžběta Kružicová (cvičící)
MUDr. Tomáš Parák, Ph.D. (cvičící)
PharmDr. Lenka Paráková, Ph.D. (cvičící)
doc. MVDr. Pavel Suchý, Ph.D.
Ústav farmakologie a toxikologie - Ústavy - Farmaceutická fakulta
Út 9:55–11:35 Učebna botaniky, 221
  • Rozvrh seminárních/paralelních skupin:
FATO1_14/01: každé liché úterý 11:50–13:30 Učebna botaniky, 221
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Cíle předmětu
The aim of this subject is to provide students basic knowledge in the area of toxicology. Modern toxicology is an interdisciplinary scientific discipline focused on interactions of xenobiotics with living systems, which lead to their damage or death. The subject incorporates with various disciplines, which are taught in previous years (biology, morphology, physiology and human pathophysiology).
Výstupy z učení
After completing the course the student is able to define the course Toxicology and have knowledge of basic toxicological terms. The student is able to describe in general the dangerous characteristics of substances, the mechanisms of their toxic effect and kinetics. The student has a comprehensive overview of the hazards of toxicologically important inorganic, organic and natural substances and a basic overview of the toxicity of selected pesticides, radionuclides and drugs. He orients himself in related legal regulations and has an overview of methods for testing the hazardous properties of substances.
  • Lectures

    1. Toxicology, definition and history, general terminology, classification of toxins

    2. Relationship between the substance, dose and toxic effect, toxicokinetics

    3. Mechanisms of toxic effect, factors influencing the toxic effect

    4. Toxicologically important inorganic substances

    5. Toxicologically important organic substances (I)

    6. Toxicologically important organic substances (II)

    7. Pesticides and their residues in food, ecotoxicology

    8. Toxicologically important natural substances I (herbal toxins, toxins in algae and cyanobacteria, mycotoxins)

    9. Toxicologically important natural substances II (bacterial toxins and animal toxins)

    10. Toxicology of medicinal drugs, most common medicinal drug poisonings

    11. Chemical warfare agents, radiotoxicology

    12. Drug abuse, toxicological view on newly synthesized drugs

    13. Intoxication therapy, general rules

    14. Final lesson - consultations


    1. Organisation of lessons
    Introduction into the experimental evaluation of toxicity

    2. In silico evaluation of toxicity
    The READ Across method, alternative methods for the assessment of toxicity, QSAR Tool Box, constructing valid QSAR models, the use of predictive models

    3. In vitro evaluation of toxicity
    Toxicity mechanisms on cellular level and their evaluation, tests of cytotoxicity and genotoxicity, determining EC50

    4. In vivo evaluation of toxicity
    Determining systemic toxicity and toxicity after repeated administering, testing local effect (dermal irritability, sensibilisation, eye irritation, implantation), pyrogenicity tests, carcinogenicity and reproduction toxicity)

    5. Ecotoxicology
    Circulation of pollutants in the environment, biomonitoring, effect on organisms, degradability, absorption/desorption. Drug residues in the environment.

    5. Guided visit of a toxicological laboratory
    Good laboratory practice, interpreting results of tests, most common findings ? case studies

    6. Credit and classification test

    7. Classification
    povinná literatura
  • Reichl, F.X. - Ritter, L. Illustrated Handbook of Toxicology. Thiemme Stuttgart, 2011. ISBN 978-3-13-126921-8. info
    doporučená literatura
  • Mulder, Gerard J, Dencker, Lennart. Pharmaceutical Toxicology. 2006. ISBN 978 0 85369 593 6. info
  • Phillip L. Williams. PRINCIPLES OF TOXICOLOGY. 2000. ISBN 0-471-29321-0. URL info
  • Ted A. Loomis, M.D., Ph.D., and A. Wallace Hayes, Ph.D. Loomis's Essentials of Toxicology. 1996. ISBN 978-0-12-455625-6. URL info
Výukové metody
lectures, seminars
Metody hodnocení
Classification test at the end of the semester. or test questions, the student always chooses one correct answer from the options offered, for which 1 point is added. No points will be deducted for an unfilled or incorrectly answered question. The condition for passing the credit test is to achieve at least 50% of the maximum possible number of points.
Vyučovací jazyk
Informace učitele
In accordance with study and examining order of credit system of MUNI Brno.
Další komentáře
Studijní materiály
Předmět je dovoleno ukončit i mimo zkouškové období.
Předmět je zařazen také v obdobích jaro 2020, podzim 2020.
  • Statistika zápisu (nejnovější)
  • Permalink: https://is.muni.cz/predmet/pharm/podzim2021/FATO1_14