FAPC1_14 Human Physiology and Pathophysiology I

Faculty of Pharmacy
Autumn 2021
Extent and Intensity
2/1/0. 4 credit(s). Type of Completion: z (credit).
Taught in person.
MUDr. Marta Chalupová, Ph.D. (lecturer)
MUDr. Tomáš Parák, Ph.D. (lecturer)
MVDr. Jana Hložková, Ph.D. (seminar tutor)
MUDr. Marta Chalupová, Ph.D. (seminar tutor)
PharmDr. Mgr. Alžběta Kružicová (seminar tutor)
MUDr. Tomáš Parák, Ph.D. (seminar tutor)
PharmDr. Lenka Paráková, Ph.D. (seminar tutor)
MVDr. Peter Scheer, Ph.D. (seminar tutor)
Guaranteed by
MUDr. Tomáš Parák, Ph.D.
Department of Pharmacology and Toxicology - Departments - Faculty of Pharmacy
Tue 8:00–9:40 seminární místnost, -037
  • Timetable of Seminar Groups:
FAPC1_14/01: each even Tuesday 9:55–11:35 cvičebna, 140, T. Parák
Prerequisites (in Czech)
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Pathophysiology may be defined as the physiology of disease, or disordered function, or derangement of function seen in disease that is produced by the action of an etiologic agent (e.g. bacteria) on susceptible tissues or organs. The study of pathophysiology is an essential introduction to the use of drugs in clinical medicine and serves as a bridge between the basic sciences and the clinic.
Learning outcomes
After completing the course, the student will be able to: - describe the physiology and pathophysiology of the main organs - recognize subjective and objective symptoms of diseases - examine the main physiological functions - interpret examination results
    1. Introduction into pathophysiology, symptoms of diseases and their diagnosing. Disease development. Genetic factors in pathogenesis.
    2. General physiological principles. Cell physiology. Function of cell membrane and intracellular structures. Basic principles of physiological regulation.
    3. Nonspecific defence mechanisms. Inflammation. Stress. Damage of organism (physical, chemical and biological)
    4. Specific defensive mechanisms and their disorders. Cell-mediated and antibody immunity. White blood cells, functions and disorders.
    5. Physiology of the locomotive apparatus. Most common diseases of bones, muscles and joints. Inflammatory and degenerative rheumatic diseases.
    6. Physiology of digestion and absorption, metabolism of sacharides, fats and proteins. Nutritional disorders ? obesity and starving. Metabolic syndrome.
    7. Vitamins, mineral substances and trace elements. Hyper and hypovitaminoses. Diseases of deficiency and excess of mineral substances and trace elements.
    8. Physiology of blood formation. Differential diagnosing of anaemia.
    9. Hemostasis and hemocoagulation. Coagulation cascade and its disorders. Hemorrhagic and hypercoagulable states.
    10. Physiology of the circulatory system. Formation and development of atherosclerosis. Ischemic heart disease.
    11. Formation and transmission of excitement and its disorders. Inherited and acquired heart disorders.
    12. Basic principles of the blood pressure regulation. Hypertensive disease. Hypotension. Circulation failure (shock).
    13. Theory of the formation of malignant growth. Tumours and their classification. Overview of clinically most common cancers.

    Syllabus of exercises:
    I. Main physiological functions and their watching
    1. Anamnesis, interview
    2. Objective and subjective anamnesis
    3. Basic checkup (examinations)
    II. Cardiovascular system
    1. Auscultation of heart sounds
    2. Measurement of blood pressure
    3. Electrocardiography
    III. Respiratory system
    1. Auscultation of lungs
    2. Spirometry, Pulse oxymetry
    3. Basal metabolism
    IV. Nervous system
    1. Hearing tests
    2. Eye tests
    3. Optical illusions
    4. EEG

    V. Urogenital tract, diabetes mellitus
    1. Semi-quantitative urinalysis
    2. Specific weight of urine
    3. Kidney functions
    4. Menstrual cycle, ovulation, gravidity
    VI. Blood, Good laboratory practice
    1. Red blood cells
    2. Blood count
    3. Haematocrit
    4. Erythrocyte sedimentation
    5. Differential leukocytes count
    VII. Obtaining credits
    required literature
  • Stuart Ira Fox. Human Physiology. 2011. ISBN 978-0-07-337811-4. info
    recommended literature
  • COPSTEAD, BANASIK. Pathophysiology. 2005. ISBN 0-7216-0338-6. info
Teaching methods
Lectures, seminars, exercises, exercises in selected examination techniques, consultations
Assessment methods
To gain credits: Data analysis, seminar papers on given topics, written test. Completion of the course – oral exam
Language of instruction
Further comments (probably available only in Czech)
Study Materials
The course can also be completed outside the examination period.
Teacher's information
In accordance with study and examining order of credit system of the MUNI
The course is also listed under the following terms Autumn 2020.
  • Enrolment Statistics (recent)
  • Permalink: https://is.muni.cz/course/pharm/autumn2021/FAPC1_14