LF DPAPY Pathological Physiology
Name in Czech: Pathological Physiology
doctoral combined specialized
Included in the programme: LF D-PATFYZ_A Physiology, Pathological Physiology, Medical Chemistry and Biochemistry

Final state doctoral examination and defence of the doctoral thesis

The state doctoral exam has the task of proving systematic knowledge in the field of general, special, molecular and environmental pathophysiology. Particularly deep knowledge will be required in relation to the pathophysiological aspects of the topic that will be elaborated during the preparation of the dissertation.
The State Doctoral Exam consists of an Examining Board.
A necessary prerequisite for the submission of the final state doctoral examination application is the fulfilment of all the requirements determined by the doctoral board. At the latest, on the date of submitting the application, the student must submit the doctoral thesis statements (if they are determined by the decision of the doctoral board). The state doctoral examination will then proceed within one year after the submission of the application. Commonly, a part of the state doctoral examination is the discussion regarding the statements of the doctoral thesis, unless stated otherwise by the doctoral board or doctoral committee.
The state doctoral examination and the defense of the doctoral thesis are carried out according to the MU SZŘ, Articles 31, 32 and 33.
Doctoral studies are completed by writing the dissertation thesis and its defense. The following study and research duties must be fulfilled before defense of the dissertation.
The preparation of the dissertation includes especially participation in educational events, literature studies, preparation of an own project, work on an own project, data collection, sample processing, lecture presentation and clinical practice.
Partial results of the dissertation are presented in clinical seminars.
The standards of dissertation theses at LF MU are regulated by the Dean's Directive No. 5/2021 "Guidelines on the formal requirements of dissertation theses prepared at the MU Faculty of Medicine"

Requirements of the study

The basis of the doctoral studies at the Faculty of Medicine of the MU is the procedural pursuit of preparation of the doctoral thesis in close and regular interaction with the tutor and supplemented by the faculty-wide applicable terms for completing the postgraduate studies.

Before the defence of the doctoral thesis is performed, the following conditions need to be met:

- fulfil the requirements of the given individual study plan

- complete at least 4 courses of a common basis

The common courses encompass the stated fields of scientific knowledge and capabilities. They can be completed as a part of the organised courses at the MU (with cooperation with CEITEC, Faculty of Science, etc.) or through the analogical external courses (e.g. The Course in the Fundamentals of Research Work Administered by the CAS).


1. Scientific Information, medicine based on evidence (e.g. the Medicine Based on Scientific Proof course)

2. Ethical and legal aspects of research (e.g. the Bio-medicinal Research Ethics, Law, Ethics and Philosophy in Science courses)

3. Organisation of research projects and clinical trials (e.g. the Planning, Organisation and Evaluation of Clinical Studies courses)

4. Data analysis (e.g. the Analysis of Clinical Data courses)

5. Publication, presentation and grant-related skills (e.g. the Art of Research and Scientific Writing courses)

6. Computer Network User

- complete at least 4 subject-area courses (within the competence of the doctoral board)

- meet the publication activity requirements at least in the specified range (see below)

- undergo an internship abroad (with the duration of at least one month), alternatively participate in an international project (attendance at the regular project team meetings is mandatory)

- present original data at an international conference

- submit the doctoral thesis

- pass the final state doctoral examination

-acquire the total amount of 240 credits over the course of studies (in case the MU study and examination regulations change, the credit system may be bypassed at the discretion of the doctoral board).

The participation in teaching can then only reach the maximum of 150 hours/4 years
- Biomedical Research Ethics
- Molecular Biology and Genetics
- Latest Trends in Pathological Physiology
- Trends in Medical Immunology
- Life Science Seminar.
The matter of organising any individual additional lectures is a responsibility of their lecturers.

Proposal of dissertation topics and topics of defended dissertations

1. New trends in detection of apoptosis and autophagy in selected solid tumors
Archiv: http://is.muni.cz/th/flfzp/

2. Nanoparticles as a Tool for the Targeted Cancer Therapy
Archiv: http://is.muni.cz/th/dshwp/

3. Myocardial ischemia/reperfusion injury in heart transplantation with donation after circulatory death
Archiv: http://is.muni.cz/th/ktn4q/

4. Cardiovascular reactions during postural changes in patients with cervical spinal cord injury
Archiv: http://is.muni.cz/th/dh7q7/

5. The role of omentin-1 in pathophysiology of complex diseases
Archiv: http://is.muni.cz/th/me76b/

Recommended progress through the study plan


The study plan does not contain any courses.