Pharmacology

The aim of the study program is to prepare an independent pharmacologist in the field of experimental, translation, reversal or applied clinical research, or alternatively, independent academic who will apply his / her knowledge and experience in the field of education.

The results of the dissertation are published in excerpted journals and presented in professional forums.

Entry Requirements for Candidates

Completed Master's degree in fields related to the pharmacological research on:

Medical faculty or Pharmaceutical or Veterinary faculty or faculty or university disciplines: Biochemistry, Molecular Biology, Psychology, or Zoology - with obligatory additional study and successful examination of human pathological physiology.

Suggested topics of the dissertation:

Determination of expression of the brain neurotransmitter receptors in an animal model of addiction to psychotropic substances

Changes in the receptor systems of the brain under the influence of a substance dependence

Reactivity of brain neurotransmitter systems on selected antidepressants

Effects of selected antipsychotics in behavioural animal models

Effects of cannabinoid system ligands in animal models in vivo

Effects of modulators of activity of endocannabinoid system in animal models in vivo

The role of glutamatergic system in animal model of comorbidity of depression and drug dependence

The impact of genetic polymorphism of cytochromes P450 in pharmacotherapy

Modulation of the cytochrome P450 function by endocannabinoid system

The influence of pharmacokinetic factors on the efficacy and safety of pharmacotherapy including therapeutic drug monitoring

Pharmacoeconomics, Evaluation of health technologies, e-Health

Drug regulation in clinical trials, pharmacovigilance, pricing and reimbursement of medicines

Research in the area of Advanced Therapy Medicinal Products with special focus on somatic cell therapy

After successfully completing his/her studies the graduate is able to:

• understand theories, concepts and methods that represent the current trends in his / her field of dissertation
• understand theories, concepts and methods that represent the current trends in his / her field of dissertation
• understand theories, concepts and methods in the broader context of the general pharmacology
• can prepare a competitive grant application for a research project
• can interpret the results of own research and the results of research in the field in general
• can prepare a scientific article and publish in an international scientific journal
• can immediately enter the post-doctorate post in the Czech Republic and abroad
• knows and follows the principles of ethics of scientific work and specific ethical issues of its specialization
• is able to be a mentor of undergraduate or Ph.D students

Graduates of doctoral program find application in science and research in the biomedical field, more specifically in basic experimental, molecular or clinical pharmacology disciplines. Graduates are able to work individually as researchers, are able to apply for a grant to national or even international grant agencies, to publish their results in the international scientific impacted journals, to present the results of their work at an international conferences.

Graduates may find application as a university assistant in the field of pharmacology and related fields, may also find application in various positions (especially research, development, as a consultant) in the pharmaceutical industry).

The PhD student (according to the Ph.D topic) works with experimental animals or other appropriate laboratory or research methods supervised by the supervisor, later also independently.

During the course of study, the doctoral student, with the support of a supervisor, will apply for the scholarships offered for professional internships and stays relevant to the subject of the dissertation.

According to his / her possibilities and according to his / her study plan, the doctoral student participates to a limited extent in the teaching of undergraduate students of the Faculty of Medicine.

Compulsory Courses (minimum 3 required):

Neuropsychopharmacology

Behavioral pharmacology

Animal models of CNS disorders

Biochemistry

Xenobiochemistry

Specialized pharmacokinetics

Pharmacoeconomics

Optional common subjects and courses valid at the Faculty of Arts MU (minimum 5 entries required):

- detailed information with annotations, lecturers, schedule and recommended literature available on the official MU LF web site: http://www.med.muni.cz/index.php?id=124

Molecular Biology and Genetics - DSMBz01

New Trends in Pathological Physiology - DSNTz01

Trends in Medical Immunology - DSTIz01

Clinical Data Analysis - DSAK051 (Course)

Ethics of Biomedical Research - DSETz01

Rhetoric. Culture of Interpersonal Communication - DSREz01

Obtaining scientific information - DSVIz01 (course)

Planning, Organization and Evaluation of Clinical Trials - DSAM051 (Course)

Computer network user - DSUP031 (course)

English - DSAJz01 (for Medical Pharmacology - obligatory)

In the dissertation thesis the student presents the results of his work, which he / she created during his / her studies in the doctoral program. The supervisor, together with the head of the department, are responsible for providing the student with the conditions needed to meet the requirements of the doctoral program.

The student is obligated to work on the dissertation work in close cooperation with the supervisor who approves the dissertation.

The dissertation must contain original results, either already published or accepted for publication. If the student submits to the defense the results of the collective scientific work on which he has participated, the work must be clearly marked in the work. The attachment of the thesis must be the co-author's statement confirming the student's authorship and appreciating their share in the marked parts of the work.

The thesis must be submitted for defense in English. The text of the dissertation must be of good quality after the formal, grammatical and stylistic aspects. The dissertation is submitted in three copies in electronic version via IS Muni.

The dissertation thesis may also be recognized as a set of articles already published or printed or another type of publication of the work on the subject, which the student provides with a complete introduction to the subject and commentary.

The dissertation usually includes these parts

Title page

Student Acknowledgments (optional)

Student's statement on the authorship of the work (optional)

Abstract

Table of Content

Introduction

Own text of work - aims, methods, results, discussion

Conclusion

List of references

List of tables (optional)

Picture List (optional)

List of diagrams (optional)

List of abbreviations (optional)

Attachments (optional)